Søgeord (pneumoni) valgt.
23 emner vises.
1
Emergence of OXA-48-producing Klebsiella pneumoniae in Lithuania, 2023: a multi-cluster, multi-hospital outbreak
Paulius Greičius, Marius Linkevicius, Jelena Razmuk, Jekaterina Sinotova, Erik Alm, Olov Svartström, Valeria Bortolaia, Eglė Kudirkienė, Louise Roer, Rene S Hendriksen, Gabija Tamoliūnaitė, Daniel Palm, Dominique L Monnet, Anke Kohlenberg and Algirdas Griškevičius
Eurosurveillance latest updates, 19.04.2024
Tilføjet 19.04.2024
In 2023, an increase of OXA-48-producing Klebsiella pneumoniae was noticed by the Lithuanian National Public Health Surveillance Laboratory. Whole genome sequencing (WGS) of 106 OXA-48-producing K. pneumoniae isolates revealed three distinct clusters of carbapenemase-producing K. pneumoniae high-risk clones, including sequence type (ST) 45 (n = 35 isolates), ST392 (n = 32) and ST395 (n = 28), involving six, six and nine hospitals in different regions, respectively. These results enabled targeted investigation and control, and underscore the value of national WGS-based surveillance for antimicrobial resistance.
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2
Emergence of OXA-48-like producing Citrobacter species, Germany, 2011 to 2022
Julian Sommer, Hannah Reiter, Janko Sattler, Elisabetta Cacace, Jessica Eisfeld, Sören Gatermann, Axel Hamprecht and Stephan Göttig
Eurosurveillance latest updates, 12.04.2024
Tilføjet 12.04.2024
BackgroundCarbapenemase-producing Enterobacterales are a public health threat worldwide and OXA-48 is the most prevalent carbapenemase in Germany and western Europe. However, the molecular epidemiology of OXA-48 in species other than Escherichia coli and Klebsiella pneumoniae remains poorly understood. AimTo analyse the molecular epidemiology of OXA-48 and OXA-48-like carbapenemases in Citrobacter species (spp.) in Germany between 2011 and 2022. MethodsData of 26,822 Enterobacterales isolates sent to the National Reference Centre (NRC) for Gram-negative bacteria were evaluated. Ninety-one Citrobacter isolates from 40 German hospitals harbouring blaOXA-48/OXA-48‑like were analysed by whole genome sequencing and conjugation experiments. ResultsThe frequency of OXA-48 in Citrobacter freundii (CF) has increased steadily since 2011 and is now the most prevalent carbapenemase in this species in Germany. Among 91 in-depth analysed Citrobacter spp. isolates, CF (n = 73) and C. koseri (n = 8) were the most common species and OXA-48 was the most common variant (n = 77), followed by OXA-162 (n = 11) and OXA‑181 (n = 3). Forty percent of the isolates belonged to only two sequence types (ST19 and ST22), while most other STs were singletons. The plasmids harbouring blaOXA‑48 and blaOXA-162 belonged to the plasmid types IncL (n = 85) or IncF (n = 3), and plasmids harbouring blaOXA‑181 to IncX3 (n = 3). Three IncL plasmid clusters (57/85 IncL plasmids) were identified, which were highly transferable in contrast to sporadic plasmids. ConclusionIn CF in Germany, OXA-48 is the predominant carbapenemase. Dissemination is likely due to distinct highly transmissible plasmids harbouring blaOXA‑48 or blaOXA-48-like and the spread of the high-risk clonal lineages ST19 and ST22.
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3
Ongoing measles outbreak, the Federation of Bosnia and Herzegovina, December 2023 to February 2024
Sanjin Musa, Irma Salimović-Bešić, Jasmina Brkić Džambić, Nijaz Tihić, Anisa Bajramović, Suzana Arapčić, Amela Dedeić-Ljubović and Siniša Skočibušić
Eurosurveillance latest updates, 1.03.2024
Tilføjet 1.03.2024
We report on an ongoing measles outbreak in the Federation of Bosnia and Herzegovina with 141 cases notified between week 52 2023 and week 6 2024. Among those with known vaccination status, 97% were unvaccinated and the most affected group is children under the age of 5 years (n = 87) who were not vaccinated during the pandemic years. Sixty-eight cases were hospitalised, the most common complications were measles-related pneumonia and diarrhoea. The sequenced measles viruses from four cases belonged to genotype D8.
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4
Notes from the Field: Reemergence of Mycoplasma pneumoniae Infections in Children and Adolescents After the COVID-19 Pandemic, United States, 2018-2024
Morbidity and Mortality Weekly Report (MMWR), 22.02.2024
Tilføjet 22.02.2024
This report describes an increase in Mycoplasma pneumoniae, a common cause of respiratory illness, beginning in fall 2023.
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5
Hypervirulent Resistant K pneumoniae On the Rise in EU
Medscape Infectious Diseases, 15.02.2024
Tilføjet 15.02.2024
The ECDC has called for mitigating actions in the face of more European Union and European Economic Area countries reporting hypervirulent Klebsiella pneumoniae ST23. Medscape Medical News
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6
Europe Approves Exblifep for UTIs and Pneumonia
Medscape Infectious Diseases, 26.01.2024
Tilføjet 26.01.2024
Exblifep is as effective as piperacillin-tazobactam in the treatment of complicated urinary tract infections, the European Medicines Agency said. Medscape Medical News
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7
Increased incidence of Mycoplasma pneumoniae infections and hospital admissions in the Netherlands, November to December 2023
Dita C Bolluyt, Sjoerd M Euser, Dennis Souverein, Annemarie MC van Rossum, Jayant Kalpoe, Mireille van Westreenen, Marco Goeijenbier, Dominic Snijders, Dirk Eggink, Femke Jongenotter, Steven FL van Lelyveld and Marlies A van Houten
Eurosurveillance latest updates, 26.01.2024
Tilføjet 26.01.2024
Mycoplasma pneumoniae is an important cause of pneumonia and extra-pulmonary manifestations. We observed a rise in admissions due to M. pneumoniae infections starting October 2023 in a regional hospital in the Netherlands and an increased incidence in national surveillance data. The incidence in the Netherlands has not been that high since 2011. The patients had a lower median age compared with 2019 and 2020 (28 vs 40 years). M. pneumoniae should be considered in patients with respiratory symptoms, especially children.
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8
Toothbrushing in Hospital Reduces Infections and Death
Medscape Infectious Diseases, 12.01.2024
Tilføjet 12.01.2024
Daily toothbrushing was associated with a 33% reduction in risk for hospital-acquired pneumonia among inpatients, according to a recent analysis. Medscape Medical News
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9
Increase of respiratory illnesses among children in Beijing, China, during the autumn and winter of 2023
Cheng Gong, Fang Huang, Luodan Suo, Xuejiao Guan, Lu Kang, Hui Xie, Geng Hu, Peng Yang and Quanyi Wang
Eurosurveillance latest updates, 12.01.2024
Tilføjet 12.01.2024
In 2023, through an ongoing respiratory pathogen surveillance system, we observed from mid-September onwards, an increase of respiratory illness among children aged ≤ 15 years presenting at hospital outpatient clinics in Beijing, China. Data indicated that illness was caused by multiple pathogens, predominantly Mycoplasma pneumoniae. Seasonality, periodicity and high prevalence of resistance to macrolide (30 of 30 strains sequenced with the A2063G mutation) were important characteristics of the M. pneumoniae epidemic, which resulted in a rise in consultations at specialised paediatric hospitals.
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10
Mycoplasma pneumoniae epidemic in Denmark, October to December, 2023
Anne Christine Nordholm, Bolette Søborg, Pikka Jokelainen, Karina Lauenborg Møller, Lotte Flink Sørensen, Tyra Grove Krause, Søren Anker Uldum and Hanne-Dorthe Emborg
Eurosurveillance latest updates, 12.01.2024
Tilføjet 12.01.2024
We report a surge of patients, especially children and adolescents, with respiratory disease caused by Mycoplasma pneumoniae in Denmark since October 2023. While the surge has reached an epidemic level, no impact on hospital capacity has been observed; only 14% (446/3,195) of cases, primarily adults, required hospitalisation. Macrolide resistance was detected in less than 2% of samples tested. Timely monitoring of hospitalisations linked to M. pneumoniae infections has been established to inform the healthcare system, decisionmakers and the public.
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11
Communicable disease threats report, 3-9 December 2023, week 49
ECDC
ECDC Communicable Disease Threats Report, 8.12.2023
Tilføjet 8.12.2023
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 3-9 December 2023 and includes updates on respiratory virus epidemiology in the EU/EEA, SARS-CoV-2 variant classification, measles, mpox, Mycoplasma pneumoniae, West Nile virus, and MERS-CoV.
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12
Communicable disease threats report, 3-9 December 2023, week 49
ECDC
ECDC COVID-19 updates, 8.12.2023
Tilføjet 8.12.2023
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 3-9 December 2023 and includes updates on respiratory virus epidemiology in the EU/EEA, SARS-CoV-2 variant classification, measles, mpox, Mycoplasma pneumoniae, West Nile virus, and MERS-CoV.
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13
How the New Outbreak in China Is Affecting the US and Other Regions
Medscape Infectious Diseases, 5.12.2023
Tilføjet 5.12.2023
A rise in respiratory illnesses in China and clusters of pneumonia in children and resistance to a common antibiotic have specialists taking a closer look at important trends. Medscape Medical News
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14
Communicable disease threats report, 26 November - 2 December 2023, week 48
ECDC
ECDC Communicable Disease Threats Report, 2.12.2023
Tilføjet 2.12.2023
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 19 - 25 November 2023 and includes updates on human infection with influenza A(H1N2)v, influenza A(H5N1), an overview of respiratory virus epidemiology in the EU/EEA, respiratory infections due to Mycoplasma pneumoniae in the EU/EEA, HIV/AIDS surveillance 2023 (2022 data), West Nile virus, SARS-CoV-2 variant classification, and poliomyelitis.
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15
Communicable disease threats report, 26 November - 2 December 2023, week 48
ECDC
ECDC COVID-19 updates, 1.12.2023
Tilføjet 1.12.2023
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 19 - 25 November 2023 and includes updates on human infection with influenza A(H1N2)v, influenza A(H5N1), an overview of respiratory virus epidemiology in the EU/EEA, respiratory infections due to Mycoplasma pneumoniae in the EU/EEA, HIV/AIDS surveillance 2023 (2022 data), West Nile virus, SARS-CoV-2 variant classification, and poliomyelitis.
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16
Der er epidemi med mycoplasma-infektioner - også kendt som kold lungebetændelse
Statens Serum Institut, 29.11.2023
Tilføjet 29.11.2023
Der har siden sommeren været en stigning i antallet af luftvejsinfektioner med Mycoplasma pneumoniae, og forekomsten har nu nået et epidemisk niveau med væsentlig flere tilfælde end normalt.
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17
Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022
Kyriaki Tryfinopoulou, Marius Linkevicius, Olga Pappa, Erik Alm, Kleon Karadimas, Olov Svartström, Michalis Polemis, Kassiani Mellou, Antonis Maragkos, Alma Brolund, Inga Fröding, Sophia David, Alkiviadis Vatopoulos, Daniel Palm, Dominique L Monnet, Theoklis Zaoutis, Anke Kohlenberg and Greek CCRE study group
Eurosurveillance latest updates, 24.11.2023
Tilføjet 24.11.2023
BackgroundPreliminary unpublished results of the survey of carbapenem- and/or colistin-resistant Enterobacterales (CCRE survey) showed the expansion of carbapenemase-producing Klebsiella pneumoniae (CPKP) sequence type (ST) 39 in 12 of 15 participating Greek hospitals in 2019. AimWe conducted a rapid survey to determine the extent of spread of CPKP high-risk clones in Greek hospitals in 2022 and compare the distribution of circulating CPKP clones in these hospitals since 2013. MethodsWe analysed whole genome sequences and epidemiological data of 310 K. pneumoniae isolates that were carbapenem-resistant or ‘susceptible, increased exposure’ from Greek hospitals that participated in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE, 2013–2014), in the CCRE survey (2019) and in a national follow-up survey (2022) including, for the latter, an estimation of transmission events. ResultsFive K. pneumoniae STs including ST258/512 (n = 101 isolates), ST11 (n = 93), ST39 (n = 56), ST147 (n = 21) and ST323 (n = 13) accounted for more than 90% of CPKP isolates in the dataset. While ST11, ST147 and ST258/512 have been detected in participating hospitals since 2013 and 2014, KPC-2-producing ST39 and ST323 emerged in 2019 and 2022, respectively. Based on the defined genetic relatedness cut-off, 44 within-hospital transmission events were identified in the 2022 survey dataset, with 12 of 15 participating hospitals having at least one within-hospital transmission event. ConclusionThe recent emergence and rapid spread of new high-risk K. pneumoniae clones in the Greek healthcare system related to within-hospital transmission is of concern and highlights the need for molecular surveillance and enhanced infection prevention and control measures.
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18
Emergence and rapid dissemination of highly resistant NDM-14-producing Klebsiella pneumoniae ST147, France, 2022
Cécile Emeraud, Aba Mahamat, Agnès B. Jousset, Sandrine Bernabeu, Tania Goncalves, Camille Pommier, Delphine Girlich, Aurélien Birer, Christophe Rodriguez, Jean-Michel Pawlotsky, Thierry Naas, Rémy A. Bonnin and Laurent Dortet
Eurosurveillance latest updates, 20.10.2023
Tilføjet 20.10.2023
BackgroundSince 2021, an emergence of New Delhi metallo-β-lactamase (NDM)-14-producing Klebsiella pneumoniae has been identified in France. This variant with increased carbapenemase activity was not previously detected in Enterobacterales. AimWe investigated the rapid dissemination of NDM-14 producers among patients in hospitals in France. MethodsAll NDM-14-producing non-duplicate clinical isolates identified in France until June 2022 (n = 37) were analysed by whole genome sequencing. The phylogeny of NDM-14-producers among all K. pneumoniae sequence type (ST) 147 reported in France since 2014 (n = 431) was performed. Antimicrobial susceptibility testing, conjugation experiments, clonal relationship and molecular clock analysis were performed. ResultsThe 37 NDM-14 producers recovered in France until 2022 belonged to K. pneumoniae ST147. The dissemination of NDM-14-producing K. pneumoniae was linked to a single clone, likely imported from Morocco and responsible for several outbreaks in France. The gene blaNDM-14 was harboured on a 54 kilobase non-conjugative IncFIB plasmid that shared high homology with a known blaNDM-1-carrying plasmid. Using Bayesian analysis, we estimated that the NDM-14-producing K. pneumoniae ST147 clone appeared in 2020. The evolutionary rate of this clone was estimated to 5.61 single nucleotide polymorphisms per genome per year. The NDM-14 producers were highly resistant to all antimicrobials tested except to colistin, cefiderocol (minimum inhibitory concentration 2 mg/L) and the combination of aztreonam/avibactam. ConclusionHighly resistant NDM-14 producing K. pneumoniae can rapidly spread in healthcare settings. Surveillance and thorough investigations of hospital outbreaks are critical to evaluate and limit the dissemination of this clone.
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19
Rapid spread of a novel NDM-producing clone of Klebsiella pneumoniae CC147, Northern Italy, February to August 2023
Irene Mileto, Greta Petazzoni, Marta Corbella, Stefano Gaiarsa, Cristina Merla, Angela Kuka, Marina Ramus, Cristina Terulla, Micaela Brandolini, Antonio Piralla, Patrizia Cambieri and Fausto Baldanti
Eurosurveillance latest updates, 20.10.2023
Tilføjet 20.10.2023
New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae (Kp) ST147 caused a large multi-hospital outbreak in Italy from 2018 to 2021. We describe a new ST6668 NDM-producing Kp clone, belonging to CC147, which rapidly spread across hospitals in the Pavia province (Northern Italy) from February to August 2023. Genomic analyses revealed that ST6668 is different from ST147 and fast evolving. As shown here, genomic surveillance programmes are useful for tracking the spread of new clones with reduced susceptibility to most antibiotics.
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20
Pneumonia, Not Just Inflammation, May Cause Severe COVID
Medscape Infectious Diseases, 26.09.2023
Tilføjet 26.09.2023
New research from Northwestern University and the University of Wisconsin, however, is pointing to bacterial pneumonia as the cause of many severe COVID deaths. WebMD Health News
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21
Worm Pulled From Woman's Brain in Case That 'Stunned'
Medscape Infectious Diseases, 22.09.2023
Tilføjet 22.09.2023
A 64-year-old woman diagnosed with pneumonia had abdominal pain, diarrhea, dry cough, and night sweats. A year of inexplicable symptoms ended in an open biopsy and a live, stringlike worm. Medscape Medical News
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22
Three Cases of Community-Acquired Pneumonia
Medscape Infectious Diseases, 19.09.2023
Tilføjet 19.09.2023
Clinicians should consider all three etiologies on community-acquired pneumonia presentation to improve antimicrobial stewardship and patient outcomes. CDC Expert Commentary
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23
Sustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1UK and diverse emm12 isolates, Portugal, September 2022 to May 2023
Catarina Gouveia, Maria Paula Bajanca-Lavado, Rafael Mamede, Ana Araújo Carvalho, Fernanda Rodrigues, José Melo-Cristino, Mario Ramirez, Ana Friães, Portuguese Group for the Study of Streptococcal Infections and Portuguese Study Group of Pediatric Invasive Streptococcal Disease
Eurosurveillance latest updates, 8.09.2023
Tilføjet 8.09.2023
Since autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79). Genomic sequencing (n = 55) revealed multiple genetic lineages, dominated by the M1UK sublineage (26/55) and more diverse emm12 isolates (12/55).
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