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Aktuelle smitsomme sygdomme [+20]
Udarbejdet af arbejdsgruppe fra Dansk Selskab for Infektionsmedicin og Dansk Fertilitetsselskab.
Fællesregional retningslinje for udlevering af forebyggende medicin mod HIV (PrEP), udgivet af Danske Regioner.
Udarbejdet af arbejdsgruppe under Dansk Selskab for Infektionsmedicin
Udarbejdet af DSI's arbejdsgruppe vedrørende antiretroviral terapi
Om håndtering og opfølgning for at minimere risiko for smitte med bl.a. HIV, HBV og HCV.
…medicin i form af f.eks TNF-α hæmmere eller andre immunsupprimerende biologiske lægemidler, hvor der er øget risiko for tuberkulosereaktivering.
Guideline dækker ikke børn, personer med medfødt immundefekt, HIV positive, patienter i dialyse, patienter med dysreguleret diabetes, silicose, erhvervede immundefekter eller patienter i konventionel kortvarig kemoterapi.
Denne guideline omhandler ikke klassisk smitteopsporing blandt tuberkuloseeksponerede eller udredning på mistanke om aktiv tuberkulose.
…r (BMSL) til patienter i forhold til risiko for tuberkulose (TB), Humant Papillom Virus (HPV), Hepatitis B og C (HBV og HCV), Varicella Zoster Virus (VZV), Herpes Simplex Virus (HSV), Cytomegalovirus (CMV), Epstein Barr Virus (EBV) og Humant Immundefekt Virus (HIV) og øvrige infektioner.
Vejledningen er udarbejdet af repræsentanter fra Dansk Selskab for Gastroenterologi og Hepatologi (DSGH), Dansk Reumatologisk Selskab (DRS), Dansk Dermatologisk Selskab (DDS) og Dansk Selskab for Infektionsmedicin (DSI).
Arrangeret af Yngre Infektionsmedicinere
Henvendelse til Danske regioner
Bl.a. om HIV, hepatitis, resistente bakterier og immundefekt
Bl.a. om HIV, hepatitis, influenza og CNS infektioner
Bl.a. om HIV, hepatitis, cystisk fibrose og nye guidelines
Correspondence regarding "Use of statins and risk of AIDS-defining and non-AIDS-defining malignancies among HIV-1 infected patients on antiretroviral therapy"
DANHIV blev oprettet som en regional klinisk kvalitetsdatabase i RegionH i sommeren 2015. Imidlertid har projektet fungeret som Det Danske HIV Kohorte Studie (DHK) siden 1998. DHK har fungeret som en kombineret kvalitetsdatabase og forskningsdatabase. Data i DHK går tilbage til 1. januar 1995, hvorfor vi allerede nu kan vise udviklingen over en lang årrække for de forskellige indikatorer.
Bl.a. om sygdom efter udlandsrejse, resistens og kroniske virale infektioner
Forfattet af DSI's arbejdsgruppe vedrørende antiviral behandling
Bilag til Retningslinjer for screening og profylakse før behandling med biologiske lægemidler (2023)
Formål:
At kursisten skal opnå en forståelse af HIV-infektionen herunder viden om dens epidemiologi, patogenese, patofysiologi, diagnose, forebyggelse, behandlingsmuligheder og prognose samt viden om diagnostik og behandlingen af AIDS-definerende sygdomme og de hyppigste sexuelt overførte sygdomme.
Tid og sted:
Hvidovre Hospital. Lokale 10 i undervisningsbygningen.
Delkursusledere:
Ann-Brit Eg Hansen og Ole Kirk.
Program:
Mandag 3…
…me og biologisk terrorisme. Specialet er karakteriseret ved et sygdomspanorama hvor sygdommenes prævalens såvel som incidens ændres hurtigt på lokalt og globalt plan. Over de seneste tyve år har specialet udviklet sig til at håndtere behandlingen af HIV og AIDS. I de seneste år er nye alvorlige infektionssygdomme som SARS, fugleinfluenza, West Nile virus, Hanta virus, Nipah virus, og Hendra virus tilkommet…
…na Weis, Britta Tarp, Lone Mygind
National Strategi for Hepatitis C (Sundhedsstyrelsen 2023),
Kronisk viral hepatitis:
Nina Weis (tovholder), Peer Brehm Christensen, Alex Lund Laursen
Hepatitis B (2018),
Hepatitis C (2022),
HIV:
Antiretroviral terapi:
Jan Gerstoft (tovholder), Jens Lundgren, Henrik Nielsen, Alex Laursen, Niels Obel, Isik Somuncu, Gitte Kronborg, Ann-Brit Eg Hansen
Antiviral behandling af hiv smittede personer (2024),
Fertilitetsbehandling ved HIV og…
…ktioner og kronisk hepatitis:
Dato for næste kursus.
2026:
Sted.
Odense Universitetshospital.
Delkursusledelse.
Lone Mygind, Micha Jepsen og Belinda Mössner.
Tidligere kurser.
4. og 5. december 2023.
3. og 4. december 2020.
HIV-infektion:
Næste kursus.
30. og 31. oktober 2025 (2 dage):
Sted.
Aarhus Universitetshospital (AUH) .
Delkursusledelse.
Ole Schmeltz Søgaard og Lene Ryom Nielsen .
Program.
Afventer.
Tidligere kurser.
12. og 13. oktober 2022…
…me og biologisk terrorisme. Specialet er karakteriseret ved et sygdomspanorama hvor sygdommenes prævalens såvel som incidens ændres hurtigt på lokalt og globalt plan. Over de seneste tyve år har specialet udviklet sig til at håndtere behandlingen af HIV og AIDS. I de seneste år er nye alvorlige infektionssygdomme som SARS, fugleinfluenza, West Nile virus, Hanta virus, Nipah virus, og Hendra virus tilkommet…
…iklen summerer på en rimelig afbalanceret måde den globale kontrovers, som 2013 var præget af, om hvorvidt ART skal benyttes som forebyggende middel, som led i en individuel-baseret eller en folkesundsbaseret strategi for at reducere smittespredning af HIV…
Professor Henrik Nielsen kommenterer: Trods indiskutable fremskridt i den farmakologiske behandling af HIV/AIDS er der fortsat områder med plads til forbedring.
Blandt patienter i kronisk behandling er HAND (HIV-associated neurocognitive disorder) et af disse eksempler…
Professor Jens Lundgren kommenterer: I 2014 var verden optaget af Ebola udbruddet i Vest Afrika – et udbrud der blev erkendt hurtigt (om end den internationale assistance lod vente på sig).
Vedlagte artikel belyser detaljeret hvorledes HIV pandemien startede i 1920’erne og hvor det jo som bekendt tog over 60 år af finde ud at der overhovedet var et problem.
Synes artiklen er godt skrevet og giver et indblik i Afrika for 90 års siden og de ingredienser der skulle til for at ud…
Professor Lars Østergaard kommenterer: Jeg vil gerne anbefale vedlagte artikel som julemånedslæsning. Grundene er som følger: 1) Det vises for første gang, at et medikament kan reaktivere latent HIV-virus under samtidig HAART-behandling i en grad, så virus kan påvises i perifert blod. 2) Der er (omend videnskaligt svage) indicier på, at HIV-reservoir kan reduceres hos nogle patienter, og at effekten af det innate immunforsvar er af betydning herfor…
Professor Jens Lundgren kommenterer: I 2015 nåede WHO sit mål om at få 15 million på behandling. START studiet afklarede også at alle HIV+ personer har gavn af at starte på HIV behandling. Der er fortsat mere end 20 millioner der endnu ikke er startet. Hovedparten bor i ressource svage lande hvor adgang til monitorering af HIV mængden er begrænset og behandlingsskift pga behandlingssvigt er derfor primært drevet af klinik og CD4 tals måling…
… dolutegravir, især når det kombineres med TAF fremfor tenofovir DF, forårsager markant vægtøgning. Især hos kvinder med mørk hudfarve. Artiklen gør indtryk af en række grunde:. Da dolutegravir blev markedsført havde det profilen som det eneste HIV præparat uden bivirkninger. Læring: der er ingen medicinske præparater der ikke har nogle bivirkninger, og typen af bivirkninger kan ikke altid forudsiges udfra markedsføringsstudier (fase I-III)…
Professor Jens Lundgren kommenterer: Første lægemiddel mod SARS-CoV-2 udviklet fra ”bunden” – bruger et gammel trick fra HIV medicinen (ritonavir) for at holde plasma koncentrationerne oppe. Læringen er, at det tager tid at lave nye lægemidler helt fra bunden, men det er noget nær en verdensrekord så hurtigt som det skete under pandemien – både hvad angår vacciner (hvor det tog < 1 år fra design ex vivo til markedsføring), men altså ca 2 år for lægemidler som dette.
Professor Lars Østergaard kommenterer: Indimellem kommer der studier, som er så overbevisende, at det sætter en ny behandlingsstandard.
Det kan f.eks…
Professor Troels Lillebæk kommenterer: Interessant systematisk review i AIDS om udbytte af screening for tuberkulose infektion (TBI) blandt personer, der lever med HIV (PLHIV) i tuberkulose lav-incidens lande (som Danmark) . Inddraget i alt 51 undersøgelser med 65.930 PLHIV hvoraf 12 % havde en positiv LTBI-test, som var stærkt relateret til oprindelsesland og eksponering for TB )…
30. oktober, Aarhus Universitetshospital (AUH)
24. september, Stockholm, Sverige
Nyt fra tidsskrifterne [+20]
Der er mere end 20 resultater, måske du vil se flere resultater her?
BMJ Open
13.06.2025
. Introduction. HIV and tuberculosis (TB) are two of the most devastating disease conditions of public health concern globally. A co-infection of the two diseases poses serious health challenges to patients including mental health problems, ranging from mild to severe, with differing outcomes. This systematic review aims to assess the correlates of HIV-TB co-infection and mental health of adults living in sub-Saharan Africa. . Methods and analysis…
PLoS One Infectious Diseases
13.06.2025
by Dorothy Serwaa Boakye, Samuel Adjorlolo . Background Adolescents living with HIV/AIDS in sub-Saharan Africa face a disproportionate burden of mental health challenges and suboptimal antiretroviral therapy (ART) adherence, which can have significant consequences for their overall health and well-being. While multiple family group therapy (MFGT) has shown promise in improving outcomes for ALHIV in other settings, the intervention is yet to be wholly adapted and evaluated in the Ghanaian context…
Journal of Infectious Diseases
13.06.2025
Abstract . Background . Characterizing clustering rates of people with HIV in high-risk populations can offer insights on the HIV epidemic, enhancing efforts to control its spread.Methods . We investigated longitudinal dynamics of clustering rates among individuals newly diagnosed with HIV-1. Data were extracted from medical records of all people with HIV in Rhode Island with available viral sequences…
Journal of Infectious Diseases
12.06.2025
Abstract . Background . Mpox, caused by the Monkeypox virus (MPXV), remains a global health concern with nearly half of all cases occurring among individuals living with HIV. While recent studies have advanced our understanding of poxvirus pathogenesis, the molecular effects of mpox and HIV co-infection are still poorly understood…
Clinical Microbiology and Infection
11.06.2025
The aim of this study was to evaluate humoral and cellular immune responses in people living with HIV (PLWH) following successive COVID-19 vaccine booster doses, in order to determine immune correlates associated with clinical outcomes (avoiding severe infections) and epidemiological impacts (preventing new infections), a topic of growing controversy in this vulnerable population.
Proceedings of the National Academy of Sciences
11.06.2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 23, June 2025. SignificanceHIV-1 entry is an important therapeutic target. However, the exact subcellular location of HIV-1 entry into primary CD4+T cells, a major in vivo host for HIV-1, remains undetermined. The current study shows that macropinosomes serve as a site .
AIDS
11.06.2025
Objectives: . National HIV Behavioral Surveillance (NHBS) conducts surveillance among key populations, including persons who inject drugs (PWID). NHBS data can be used to monitor progress toward national goals, including Ending the HIV Epidemic (EHE). EHE strategies include HIV testing (Diagnose), rapid linkage to HIV treatment (Treat), and increasing access to pre-exposure prophylaxis (PrEP) and syringe services programs (SSPs) (Prevent)…
AIDS
11.06.2025
Objective: . To describe the association of metabolic dysfunction-associated steatotic liver disease (MASLD) with clinically significant liver fibrosis (CSLF) in people with HIV from Rio de Janeiro (Brazil). Design: . Cross-sectional study . Methods: . We analyzed data from the baseline visit of the PROSPEC-HIV-study (NCT02542020)…
AIDS
11.06.2025
Objective: . Persons with HIV (PWH) are at risk for myocardial structural changes, which can progress to diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF). We explored the AHA PREVENT HF (Predicting Risk of cardiovascular disease EVENTs for Heart Failure) risk score in relation to cardiac magnetic resonance (CMR) imaging. Design: . This cross-sectional study included 37 PWH on ART, ages 40–65, without known CVD who underwent CMR. Methods: …
AIDS
11.06.2025
Objective: . We investigate the risk of acquiring HIV or HSV-2 among young women who sell sex (YWSS) in rural South Africa. Design: . A representative population-based prospective cohort study of adolescent girls and young women (AGYW). Methods: . Between 2017 and 2019 we interviewed a random sample of AGYW (13–30 years) annually and collected dried blood spot samples for HIV and HSV-2 serology. YWSS were defined as engaging in transactional sex and/or sex work in the past 12 months…
AIDS
11.06.2025
…nd-generation INSTI-based regimen may have a higher risk of developing metabolic syndrome (MetS) compared to those on other antiretroviral classes. This study aimed to describe the incidence of MetS at 48 weeks, based on ATP III criteria, in people with HIV (PWH) who started antiretroviral therapy (ART) with a DTG/ABC/3TC-based regimen compared to those receiving a BIC/TAF/FTC-based regimen. Design: . A randomized, open-label clinical trial was conducted in PWH with no prior exposure to ART. Methods: …
AIDS
11.06.2025
Objective: . The accumulation of excess lipids within skeletal muscle, which can progress to overt myosteatosis, is more common among persons with HIV (PWH) and contributes to the development of frailty, impaired mobility, and metabolic dysregulation. Excess free fatty acids (FFA) can impair muscle mitochondrial function, which is reflected in higher plasma levels of several acylcarnitines…
AIDS
11.06.2025
Background: . Despite increasing multimorbidity among people with HIV, its impact on health outcomes over time remains uncertain. We explored how distinct multimorbidity patterns affect a broad range of health outcomes over a 3–5-year period. Methods: . Principal component analysis (PCA) was used to identify multimorbidity patterns at baseline. Burden z-scores were calculated for each individual/pattern at baseline and a follow-up visit, and the differences in scores over time were examined…
JAMA
11.06.2025
For the past 2 decades, the US President’s Emergency Plan for AIDS Relief (PEPFAR) has provided more than $110 billion toward the global HIV/AIDS response. If this funding stops—as suggested by a recent directive—infections and deaths are expected to rise significantly, including 1 million new pediatric cases of HIV and 460 000 additional AIDS-related deaths in children by 2030, according to a health policy analysis recently published in The Lancet.
Journal of Acquired Immune Deficiency Syndromes
11.06.2025
Background. . Type 2 diabetes (T2D) is among the most frequent comorbidities in people with HIV (PWH) and occurs more often in PWH than in people without HIV. Polygenic risk scores (PRS) can be used to summarize the genetic risk for T2D, but it is unknown to what extent HIV-specific factors impact on or interact with genetic risk factors. Methods. …
Journal of Acquired Immune Deficiency Syndromes
11.06.2025
Background: . Psychological and social support to adolescents living with HIV remains undocumented and unaddressed in Central Africa. This study aimed to assess effectiveness of a peer-facilitated community-based support in improving mental health among Cameroonian adolescents living with vertically acquired HIV (ALHIV). Setting: . The study was conducted in a national referral hospital in Yaounde, Cameroon. Methods: . This was a parallel randomized controlled trial in ALHIV…
Journal of Acquired Immune Deficiency Syndromes
11.06.2025
Background: . Higher levels of inflammation are associated with increased HIV disease progression, but data are lacking in postpartum women with HIV (WHIV), who generally have a distinct immune profile. Further, the impact of discontinuation of antiretroviral therapy (ART) on inflammation is not well understood for postpartum women. We studied the relationship of ART discontinuation, inflammation, and HIV disease progression in postpartum WHIV. Setting: …
Journal of Acquired Immune Deficiency Syndromes
11.06.2025
Background: . Patients infected with multidrug-resistant (MDR) HIV-1 have limited treatment options and poor clinical outcomes. For effective suppression of viral replication, regimens with distinct mechanisms of action and nonoverlapping patterns of resistance are needed. Setting: . Studies of post-attachment inhibitor ibalizumab plus optimized background regimen (OBR) are needed to evaluate efficacy and safety of long-term use in patients with MDR HIV-1, potentially providing more treatment options…
Journal of Acquired Immune Deficiency Syndromes
11.06.2025
Introduction: . Key populations, including female sex workers (FSW), people who inject drugs (PWID), and people in serodiscordant partnerships, experience higher HIV incidence compared to the general population. Maternal HIV retesting, particularly during late pregnancy, helps detect new infections and prevent vertical HIV transmission, but optimal testing schedules among key populations are unknown. Methods: …
Journal of Infectious Diseases
10.06.2025
Abstract . Background . Type 2 diabetes mellitus (DM) is common among people with HIV (PWH). We previously reported that DM risk was greater in women of African ancestry with HIV who had mitochondrial DNA (mtDNA) haplogroup L3. We examined haplogroup associations with DM and selected soluble and cellular immune biomarkers among PWH and those without HIV in the Veterans Aging Cohort Study (VACS) Biomarker Cohort.Methods …
Aktuelle smitsomme sygdomme [+20]
Der er mere end 20 resultater, måske du vil se flere resultater her?
Medscape Infectious Diseases
13.06.2025
An 82-year-old on haemodialysis tests HIV-positive 7 months in, only for PCR to be negative, implicating flu shot antibody cross-reactivity. . Medscape UK
Medscape Infectious Diseases
11.06.2025
The U.S. Food and Drug Administration has paused Gilead Sciences' trials testing a combination of two of its experimental HIV treatments due to low levels of a type of white. . Reuters Health Information
Morbidity and Mortality Weekly Report (MMWR)
6.06.2025
This report describes the public health response to surveillance data in Malawi that identified higher-than-expected recent HIV infections
Medscape Infectious Diseases
5.06.2025
A population-based study finds that nearly 15% of individuals using HIV preexposure prophylaxis are diagnosed with alcohol use disorder within 6 months before or after starting treatment. . Medscape Medical News
Medscape Infectious Diseases
5.06.2025
With 85% 10-year survival reported in HIV-positive transplant recipients in Spain, the country is now moving toward policy reform to expand donor eligibility. . Medscape Medical News
Medscape Infectious Diseases
3.06.2025
Chronic painkiller misuse, HIV, and intense nose itching culminate in full septum loss — an alarming formication presentation that calls for routine dental screening. . Medscape UK
Medscape Infectious Diseases
29.05.2025
Women living with HIV have significantly lower odds of viral suppression when their adherence to antiretroviral therapy is below 90%, a recent study shows. . Medscape Medical News
Medscape Infectious Diseases
24.05.2025
The two active substances are antivirals that inhibit HIV reverse transcriptase through incorporation into the viral DNA, resulting in chain termination. . Medscape Medical News
Medscape Infectious Diseases
14.05.2025
Testing and monitoring of HIV patients across South Africa have fallen since the United States cut aid that funded health workers and clinics, with pregnant women, infants. . Reuters Health Information
Medscape Infectious Diseases
14.05.2025
A game-changing program that identified thousands of new HIV cases is targeted to close ahead of schedule. . Medscape Medical News
Medscape Infectious Diseases
13.05.2025
A machine learning model outperformed biological tests for latent TB in identifying HIV-positive people at high risk of developing TB in Switzerland. . Medscape Medical News
Eurosurveillance latest updates
9.05.2025
. Background. HIV testing based on indicator conditions is recommended to diagnose HIV earlier. . . Aim. Our aim was to assess opportunities for earlier diagnosis of HIV. . . Method. This is a retrospective study on people living with HIV (PLWH) included in the national HIV register…
Medscape Infectious Diseases
8.05.2025
A cross-sectional analysis shows that long-acting antiretroviral therapy sustains viral suppression regardless of initial viremia in patients with HIV. . Medscape Medical News
Morbidity and Mortality Weekly Report (MMWR)
7.05.2025
CDC updates HIV nonoccupational postexposure prophylaxis recommendations Meta Keywords:
Medscape Infectious Diseases
7.05.2025
AIDS-related illnesses continue to be the most common cause of hospital admissions for people living with HIV worldwide, followed by bacterial infections, a meta-analysis shows. . Medscape Medical News
Medscape Infectious Diseases
29.04.2025
Patients in historically redlined neighborhoods experience significantly longer delays in achieving HIV viral suppression than those in non-redlined areas. . Medscape Medical News
Medscape Infectious Diseases
16.04.2025
Despite being effective, PrEP uptake in Europe remains low due to issues like cost, access, and stigma, hindering its potential to reduce HIV transmission. . Medscape Medical News
Medscape Infectious Diseases
11.04.2025
-The Trump administration plans to remove all the members of a presidential advisory council on HIV/AIDS and provided no timeline for replacing them as the government. . Reuters Health Information
Medscape Infectious Diseases
9.04.2025
Global progress against HIV is at risk as aid cuts could trigger millions of new infections and deaths, potentially setting efforts back to 2010 levels, experts warn. . Medscape Medical News