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Coronavirus -- ChinaAn unexplained pneumonia in China caused the Korean quarantine authorities to strengthen the quarantine, and a fever-sensing camera is installed to monitor the body temperature of Chinese tourists who entered Korea at Incheon Port 1 International Passenger Terminal. Pneumonia confirmed by the new coronavirus, which is prevalent in Wuhan, China, was confirmed for the first time on [20 Jan 2020]. According to health officials, a Chinese woman, A, who arrived at Incheon International Airport
Coronavirus -- ChinaOn [18 Jan 2020], 0 cases were cured, 5 cases were discharged, 59 cases were newly added, and 1 died. On [19 Jan 2020], 0-22 hours, 1 case was discharged, and 77 cases were newly added.On the basis of continuously regulating the operation of pre-screening and triage of all types of medical institutions at all levels, our city has further increased the screening of suspected cases of pneumonia due to new coronavirus in accordance with the newly revised pneumonia diagnosis and treatment plan
Coronavirus -- ChinaClinical samples and CoV cell culture supernatantsRespiratory samples were obtained during 2019 from patients hospitalized at Charite medical center and tested by the NxTAG Respiratory Pathogen Panel (Luminex) or in cases of MERS-CoV by the MERS-CoV upE assay as published before (1). Cell culture super-natants from typed coronaviruses were available at our research and clinical laboratories. The typed avian influenza virus RNA (H5N1) was obtained from the German Society for Promotion of
Chronic Wasting Disease -- Worldwide/UnknownA new study was the 1st to find in vitro evidence of chronic wasting disease (CWD) in samples of deer semen, the kind typically used for breeding purposes on deer farms. The study was published in PLOS One.Tracy Nichols, PhD, an author of the study and a cervid health specialist staff officer with the United States Department of Agriculture (USDA), said the findings will not provoke a change in policy at this time. Instead they offer a necessary starting point in investigations concerning
Influenza -- Worldwide/UnknownInformation in this report is categorized by influenza transmission zones, which are geographical groups of countries, areas or territories with similar influenza transmission patternsSummary-------------In the temperate zone of the northern hemisphere, respiratory illness indicators and influenza activity continued to increase in most countries.In North America, influenza activity further increased, and although all seasonal influenza subtypes were co-circulating, there was a high
Avian Influenza H5N8 -- Czech RepublicThe presence of highly pathogenic avian influenza has been confirmed in the Czech Republic 3 years after the previous event. The outbreak affects a small poultry farm in Stepanov nad Svratkou, in the Vysocina Region. The virus was introduced by wild water birds. It is a highly pathogenic subtype of H5N8 virus, fatal to birds, but transmission to humans has not yet been reported.The infected stock were 12 hens, 6 of which died within 2 days, and there were 3 ducks. Veterinary inspectors
Other Human Disease -- United StatesCDC is facing criticism over its response to a polio-like illness. The Centers for Disease Control and Prevention has confirmed 10 additional cases of acute flaccid myelitis.An Ohio teen is determined to walk again despite doctors' warnings that she may not after she contracted a rare polio-like illness that's left her paralyzed from the waist down.IK, a catcher on her middle school's softball team, said it started with what felt like a cramp in her leg on Christmas. "I just thought,
Trichinosis -- Italy
Nipah/Hendra Virus -- BangladeshMedia sources in Bangladesh are reporting a Nipah virus infection in the city of Khulna. The reported case is a 20-year-old female who has been hospitalized since last Saturday [11 Jan 2020] at the Khulna Medical College Hospital (KMCH)."A medical board has confirmed her infection by Nipah virus. As her infection is a risk to other patients, she is being treated separately at the hospital's Medicine unit 1," said SM Kamal Hossain, chief of KMCH Medicine Department.According to the
Coronavirus -- ChinaIssuing authority: Wuhan City health committeeOn [17 Jan 2020], national and provincial experts screened some cases of unexplained pneumonia that were screened by community health service centers in the city and found and treated [these cases] in various hospitals based on their clinical manifestations, epidemiological history, and optimization. The positive results of the novel coronavirus nucleic acid detected by the subsequent detection kit were comprehensively judged, and 17 cases of
Mumps -- United KingdomOutbreaks of mumps have become widespread around the country, the Health Service Executive (HSE) has said. There were 132 cases of mumps reported to the Health Protection Surveillance Centre last week.Mumps is a highly contagious viral infection, and the most common symptom of mumps is a swelling of the parotid glands. The glands are located on both sides of the face, and the swelling gives a person a distinctive "hamster face" appearance.Speaking on RTE's Morning Ireland, Dr. Kevin
Food-related toxin -- BrazilSeventeen people are suspected to have been poisoned and one person has died in Brazil after drinking beer. Sixteen males and one female aged 23-76 years old are thought to have suffered diethylene glycol poisoning. Four cases have been confirmed, and the remaining 13 are under investigation as they have showed similar symptoms, according to the Minas Gerais State Department of Health.The 1st person was admitted to a hospital on 30 Dec 2019 suffering from acute renal failure and
Chronic Wasting Disease -- United StatesThe Michigan Department of Agriculture and Rural and Development (MDARD) has confirmed chronic wasting disease (CWD) in 3 white-tailed deer from a Newaygo County deer farm. All 3 deer were 4.5 years old. The samples were submitted for routine testing as part of the state's CWD surveillance program for farmed deer.To date, CWD has not been detected in free-ranging deer in Newaygo County. As part of MDARD's disease response, an investigation will be conducted to rule out exposure of any
Equine Herpes Virus -- CanadaOn 6 Jan 2020, the Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA) was notified of 2 cases of equine abortion in Simcoe County. Both cases were confirmed to be caused by equine herpesvirus type 1 (EHV-1). Both mares aborted during their 10th month of pregnancy, and both mares arrived from an out-of-province location in December .A 3rd mare was exposed to the infected mares, but she has remained unaffected.The farm manager kept the new mares separate from the
Monkeypox -- CameroonOriginal public tweetLocal authority orders strict health monitoring after minor dies from monkeypox virus in Ayos, Cameroon: #AlerteSante [health alert] of a case of monkeypox in the town of Ayos, Center region. [There is] a deceased infant. This note indicates how the virus is contracted, not how to prevent it or what to do after the symptoms. I think it is urgent to communicate on it.--Communicated by:ProMED-mail[This very brief report provides little information about
African Swine Fever -- PolandThe African swine fever (ASF) epizootic in the west of the country does not slow down. In the past 7 days, another 20 cases of the disease have been confirmed in the wild boar population of Poland's Wielkopolska and Lubuskie regions, as can be seen on the map published by the Chief Veterinary Inspectorate.Most cases of the disease occurred in the Lubuskie Voivodeship, most of them in the Sława commune belonging to the Wschowa poviat. In addition, the disease occurred in the Nowosolski
Coronavirus -- ChinaMinistry of Public Health screening for travelers from Wuhan City, People's Republic of China found confirmed coronavirus pneumonia of the 2019 strain from a 2nd individual, which is currently under medical supervision at Bamrasnaradura Institute waiting for the results of repeated lab tests. There has been no outbreak of the new strain of the coronavirus in Thailand.Today ([17 Jan 2020]) at the Department of Disease Control of the Ministry of Public Health in Nonthaburi Province, Dr.
Anthrax -- ZimbabweAt least 177 cattle have died from anthrax while 87 people were treated for the disease in various clinics and hospitals after eating meat from cattle that died from the infection during this season. Anthrax is a bacterial disease that affects a wide range of animals and human beings.Livestock, particularly cattle, take up anthrax bacteria during grazing, while people get infected when they handle or eat anthrax-infected meat. Anthrax disease occurs throughout the year, but in Zimbabwe,
Avian Influenza H5N6 -- ChinaChina's agriculture ministry said on [Thu 16 Jan 2020] it had found a new case of highly pathogenic H5N6 avian flu in a flock of about 150 wild swans in the western Xinjiang region.One had died and another was sick, it said in a statement on its website.The ministry reported a case of the same strain of bird flu in swans in the region last week [week of 6 Jan 2020].--Communicated by:ProMED-mail[A highly pathogenic avian influenza (HPAI) subtype H5N6 was detected in wild
Vitamin E acetate, which has been detected in tetrahydrocannabinol -containing e-cigarette, or vaping, products, is strongly linked to the e-cigarette, or vaping, product use-associated lung injury outbreak; however, evidence is not sufficient to rule out the contribution of other chemicals of concern, including chemicals in either THC- or non-THC-containing products, in some reported EVALI cases.
CDC updates demographic characteristics, self-reported substance use, and hospitalization dates for e-cigarette, or vaping, product use-associated lung injury patients reported to CDC, as well as the distribution of emergency department visits related to e-cigarette, or vaping, products.
Polio -- PhilippinesNew wild poliovirus isolates reported this week:AFP cases: 7Environment: 5Others: 0New cVDPV isolates reported this week:AFP cases: 10Environment: 8Others: 5Headlines- Pakistan intensifies cVDPV2 response efforts, focusing on comprehensive outbreak response, strengthened routine immunization, communication, and enhanced surveillance.Summary of new viruses this week (AFP cases and environmental samples):- Pakistan: 7 WPV1 cases and 5 WPV1-positive environmental
Anthrax -- ZimbabweMasvingo has been hit by an anthrax outbreak, with official figures indicating that more than 40 cattle have succumbed to the disease, while at least 60 people have been affected. Masvingo department of veterinary services provincial officer Dr Ernest Dzimwasha confirmed the anthrax outbreak, saying 46 cattle have been lost while 37 people in Bikita and 27 from Gutu have been diagnosed with the disease after consuming infected beef. "I can confirm that Gutu and Bikita districts have been
Other Plant Disease -- United StatesA severe outbreak of red node disease caused by tobacco streak virus (TSV) in snap beans has occurred in a number of fields, which resulted in significant yield losses. Some growers have to completely destroy their crops without harvesting at all. The efficient control and management of such fatal disease is very challenging. Thrips [are] a vector for the disease. However, [there is] a lack of efficacy in chemical control or IPM [integrated pest management] because of insect
Anthrax -- IndonesiaAnthrax threatens Ponjong and Semanu subdistricts in Gunung Kidul district, Yogyakarta province, after 27 residents were infected from consuming the meat of a dead cow, a local health official said on Wednesday [15 Jan 2020].On 4 Jan 2020, health workers found that 600 residents of the 2 subdistricts could have been affected by anthrax, and 78 of them were observed to have the clinical features of this disease, Sumitro, head of the Disease Prevention and Control Unit at the Gunung Kidul
Michael L Beeton, Xu-Sheng Zhang, Søren A Uldum, Cécile Bébéar, Roger Dumke, Karolina Gullsby, Margareta Ieven, Katherine Loens, Ran Nir-Paz, Sabine Pereyre, O Brad Spiller, Victoria J Chalker and the ESCMID Study Group for Mycoplasma and Chlamydia Infections (ESGMAC) Mycoplasma pneumoniae subgroup
Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia, with large epidemics previously described to occur every 4 to 7 years.
To better understand the diagnostic methods used to detect M. pneumoniae; to better understand M. pneumoniae testing and surveillance in use; to identify epidemics; to determine detection number per age group, age demographics for positive detections, concurrence of epidemics and annual peaks across geographical areas; and to determine the effect of geographical location on the timing of epidemics.
A questionnaire was sent in May 2016 to Mycoplasma experts with national or regional responsibility within the ESCMID Study Group for Mycoplasma and Chlamydia Infections in 17 countries across Europe and Israel, retrospectively requesting details on M. pneumoniae-positive samples from January 2011 to April 2016. The Moving Epidemic Method was used to determine epidemic periods and effect of country latitude across the countries for the five periods under investigation.
Representatives from 12 countries provided data on M. pneumoniae infections, accounting for 95,666 positive samples. Two laboratories initiated routine macrolide resistance testing since 2013. Between 2011 and 2016, three epidemics were identified: 2011/12, 2014/15 and 2015/16. The distribution of patient ages for M. pneumoniae-positive samples showed three patterns. During epidemic years, an association between country latitude and calendar week when epidemic periods began was noted.
An association between epidemics and latitude was observed. Differences were noted in the age distribution of positive cases and detection methods used and practice. A lack of macrolide resistance monitoring was noted.
H Roel A Streefkerk, Roel PAJ Verkooijen, Wichor M Bramer and Henri A Verbrugh
Surveillance of healthcare-associated infections (HAI) is the basis of each infection control programme and, in case of acute care hospitals, should ideally include all hospital wards, medical specialties as well as all types of HAI. Traditional surveillance is labour intensive and electronically assisted surveillance systems (EASS) hold the promise to increase efficiency.
To give insight in the performance characteristics of different approaches to EASS and the quality of the studies designed to evaluate them.
In this systematic review, online databases were searched and studies that compared an EASS with a traditional surveillance method were included. Two different indicators were extracted from each study, one regarding the quality of design (including reporting efficiency) and one based on the performance (e.g. specificity and sensitivity) of the EASS presented.
A total of 78 studies were included. The majority of EASS (n = 72) consisted of an algorithm-based selection step followed by confirmatory assessment. The algorithms used different sets of variables. Only a minority (n = 7) of EASS were hospital-wide and designed to detect all types of HAI. Sensitivity of EASS was generally high (> 0.8), but specificity varied (0.37–1). Less than 20% (n = 14) of the studies presented data on the efficiency gains achieved.
Electronically assisted surveillance of HAI has yet to reach a mature stage and to be used routinely in healthcare settings. We recommend that future studies on the development and implementation of EASS of HAI focus on thorough validation, reproducibility, standardised datasets and detailed information on efficiency.
Thibaut Jombart, Christopher I Jarvis, Samuel Mesfin, Nabil Tabal, Mathias Mossoko, Luigino Minikulu Mpia, Aaron Aruna Abedi, Sonia Chene, Ekokobe Elias Forbin, Marie Roseline D Belizaire, Xavier de Radiguès, Richy Ngombo, Yannick Tutu, Flavio Finger, Madeleine Crowe, W John Edmunds, Justus Nsio, Abdoulaye Yam, Boubacar Diallo, Abdou Salam Gueye, Steve Ahuka-Mundeke, Michel Yao and Ibrahima Socé Fall
The ongoing Ebola outbreak in the eastern Democratic Republic of the Congo is facing unprecedented levels of insecurity and violence. We evaluate the likely impact in terms of added transmissibility and cases of major security incidents in the Butembo coordination hub. We also show that despite this additional burden, an adapted response strategy involving enlarged ring vaccination around clusters of cases and enhanced community engagement managed to bring this main hotspot under control.
Sofie Elisabeth Midgley, Kimberley Benschop, Robert Dyrdak, Audrey Mirand, Jean-Luc Bailly, Sibylle Bierbaum, Stefan Buderus, Sindy Böttcher, Anna-Maria Eis-Hübinger, Mario Hönemann, Veronika Vorobieva Jensen, Ulla Birgitte Hartling, Cécile Henquell, Marcus Panning, Marianne Kragh Thomsen, Emma B Hodcroft and Adam Meijer
Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patients required hospitalisation and five had severe neurologic manifestations. Phylogenetic analysis revealed two clusters in the B3 subclade and subclade A2/D. This circulation of EV-D68 associated with neurological manifestations stresses the importance of surveillance and diagnostics beyond expected peak years.
E. Voulgari, S.D. Kotsakis, P. Giannopoulou, E. Perivolioti, L.S. Tzouvelekis and V. Miriagou
Two ceftazidime-avibactam (CAZ-AVI)-resistant Klebsiella pneumoniae carbapenemase (KPC)-positive K. pneumoniae strains, including one pandrug resistant, were isolated in 2019 from two Greek hospitals. The strains were sequence types (ST)s 258 and 147 and both harboured similar self-transmissible IncA/C2 plasmids encoding a novel Lys234Arg variant of the Vietnamese extended-spectrum β-lactamase (VEB)-1, not inhibited by AVI (VEB-25). Conjugal transfer of VEB-25-encoding plasmids to Escherichia coli yielded CAZ-AVI-resistant clones, supporting that VEB-25 is directly linked to the derived phenotype.
The Japanese Ministry of Health, Labour and Welfare, today informed the World Health Organization (WHO) of a confirmed case of a novel coronavirus (2019-nCoV) in a person who travelled to Wuhan, China. This is the second confirmed case of 2019-nCoV that has been detected outside of China, following confirmation of a case in Thailand on 13 January. Considering global travel patterns, additional cases in other countries are likely. Coronaviruses are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. 2019-nCoV is a new strain that has not been previously identified in humans.
Coronavirus -- ChinaAt 04:00 on [15 Jan 2020], there were no new cases of pneumonitis infected with new coronavirus in our city. A total of 5 patients were discharged from the hospital and 1 new death was reported. The deceased, a male, 69 years old, became ill on [31 Dec 2019], became worse on [4 Jan 2020] and was transferred to Wuhan Jinyintan Hospital for treatment. He was admitted with severe myocarditis (myocardial enzymes reached 20 times normal, electrocardiographic abnormalities); abnormal renal function;
Anthrax -- ArgentinaAn outbreak of anthrax occurred during the last week of December of 2019 in the partido (county) of Pehuajo, Buenos Aires province.The affected herd -- 550 animals in a feedlot -- had been vaccinated 6 months previously with Sterne with vaccine from 2 different sources. A total of 16 animals died, all with similar signs of sudden death and blood extravasation from their natural openings (mouth, anus, urethra, vagina). A metatarsal bone was submitted for medulla examination and cultivation,
Avian Influenza H5N8 -- HungaryInformation received on [and dated] 15 Jan 2020 from Dr Lajos Bognar, Deputy State Secretary Chief Veterinary Officer, Food Chain Safety Department, Ministry of Agriculture, Budapest, HungarySummaryReport type: immediate notificationDate of start of the event: 10 Jan 2020Date of confirmation of the event: 14 Jan 2020Report date: 15 Jan 2020Date submitted to OIE: 15 Jan 2020Reason for notification: recurrence of a listed diseaseDate of previous occurrence: 24 Apr
The percentage of emergency department visits for pain at which an opioid was given or prescribed increased from 37.4% in 2005 to 43.1% in 2010 and then decreased to 30.9% in 2017.
This summer's record-breaking outbreak of Eastern equine encephalitis highlights the importance of cities and states ability to prepare for and respond to vectorborne disease threats.
This report describes that human immunodeficiency virus partner services for transgender women must address social and structural barriers unique to this population.
From 2011 to 2017, the total number of binge drinks consumed by U.S. adults who reported binge drinking increased significantly, from 472 to 529 drinks per year.
During 2003-2017, infant deaths due to birth defects have declined by 10% overall, but significant differences among groups, based on race and ethnicity.
In 2019, 84% of Americans think vaccinating children is important, down from 94% in 2001; 10% still believe vaccines can cause autism, according to a new Gallup survey.
Unlike the United States, most European vaccine mandates involved financial penalties, and the magnitude of the penalty was associated with greater immunization coverage.
Coronavirus -- ChinaThursday, [16 Jan 2020][Reference]Health Bureau Tuberculosis Infectious Disease SectionOffice of Infectious Disease Information ManagementOn [14 Jan 2020], a medical institution in Kanagawa Prefecture reported a case of pneumonia to a public health center under [its] jurisdiction [in an individual who had been in Wuhan, Hubei Province, China]. About this person, when he visited a medical institution on [6 Jan 2020], a report of his stay history in Wuhan was made. It was reported
Ebola -- Worldwide/Unknown
Rift Valley Fever -- LibyaInformation received on [and dated] 15 Jan 2020 from Dr Zakaria Mohamed Mustafa Elkhatal, Director General, National Centre for Animal Health (NCAH), Ministry of Agriculture, Animal & Marine Wealth, Tripoli, LibyaSummaryReport type: Immediate notificationDate of start of the event: 12 Dec 2019Date of confirmation of the event: 13 Jan 2020Report date: 15 Jan 2020Date submitted to OIE: 15 Jan 2020Reason for notification: 1st occurrence of a listed disease in the country.Causal
African Swine Fever -- RussiaInformation received on [and dated] 13 Jan 2020 from Dr Nikolay Vlasov, deputy head, Federal Service for Veterinary and Phytosanitary Surveillance, Ministry of Agriculture, Moscow, RussiaSummaryReport type: immediate notificationDate of start of the event: 3 Jan 2020Date of confirmation of the event: 7 Jan 2020Reason for notification: recurrence of a listed diseaseDate of previous occurrence: 27 Sep 2019Manifestation of disease: sub-clinical infectionCausal agent: African
Anthrax -- ZimbabweThe number of cattle that have succumbed from anthrax attack in Bikita in Masvingo province has risen to 40 from 24 last week [week of 6 Jan 2020], while 33 people have also been diagnosed with the deadly disease.Bikita District Development Coordinator Mr Benard Hadzirambwi confirmed the new developments and said the government has since availed 5000 vaccines. "We have experienced an increase in people diagnosed with anthrax from 28 to 33 while cattle deaths have also risen to 40 from 24,"
Avian Influenza H5N8 -- RomaniaInformation received on [and dated] on 14 Jan 2020 from Dr Robert Viorel Chioveanu, President, Secretary of State, Chief Veterinary Officer, Veterinary Services, National Sanitary Veterinary and Food Safety Authority, Bucharest, RomaniaSummaryReport type: immediate notificationDate of start of the event: 13 Jan 2020Date of confirmation of the event: 14 Jan 2020Report date: 14 Jan 2020Date submitted to OIE: 14 Jan 2020Reason for notification: recurrence of a listed diseaseDate
Rubella -- JapanThe posting erroneously reported the cumulative number of reported cases as an increase of 6288 in week 50 (from 2288 the prior week). The actual number of new cases was 6 with a cumulative total of 2294 cases for the week.--ProMED-mail[ProMED-mail regrets this error. - Mod.JH][See Also:Rubella - Asia: Japan
Influenza season is still in full swing and children are especially hard hit, in part as a result of a vaccine that is poorly matched to the currently predominant strain.
Although diet can influence mental health and cognition, "many common beliefs about the health effects of certain foods are not supported by solid evidence," researchers say.
Specialespecifikt kursus om immundefekt og feber af ukendt årsag
28.01.2020 - 29.01.2020
International Congress on Infectious Diseases (ICID) 2020
Kuala Lumpur, Malaysia
20.02.2020 - 23.02.2020
Dansk Selskab for Intern Medicin (DSIM) årsmøde og overrækkelse af Hagedorn prisen 2020
Novo Nordisk Fonden, Tuborg Havnevej 19, 2900 Hellerup
Conference on Retroviruses and Opportunistic Infections (CROI) 2020
Boston, Massachusetts, USA
8.03.2020 - 11.03.2020
Når CROI går i fisk - med transmissioner fra CROI 2020
10.03.2020 - 11.03.2020
Retningslinjer til sundhedsprofessionelle vedr. håndtering af infektion med zikavirus (2019)
Antiviral behandling af hiv smittede personer (2019)
Lumbalpunktur af patienter i blodfortyndende behandling (2019)
Single dose of Doxycycline for the prevention of TBRF
19.01.2020Clinical Infectious Diseases Advance Access
Characteristics of invasive pneumococcal disease (IPD) caused by emerging serotypes after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in England; prospective observational cohort study, 2014-18
19.01.2020Clinical Infectious Diseases Advance Access
The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial
17.01.2020Latest Results for BMC Infectious Diseases
Fatal hemorrhagic varicella in a patient with abdominal pain: a case report
17.01.2020Latest Results for BMC Infectious Diseases
Antifungal resistance in patients with Candidaemia: a retrospective cohort study
17.01.2020Latest Results for BMC Infectious Diseases
Hvorfor anbefaler Professor Jens Lundgren artiklen"Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV."?
Hvorfor anbefaler Professor Troels Lillebæk artiklen"The global prevalence of latent tuberculosis: a systematic review and meta-analysis."?
Hvad tænker Professor Lars Østergaard om"Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial."?
Hvorfor anbefaler Professor Thomas Benfield artiklen"Oral versus Intravenous Antibiotics for Bone and Joint Infection."?
Hvad tænker Professor Niels Obel om"Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis."?
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