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New and Improved Option for Detecting Neurologic Pathogens?
Medscape Infectious Diseases, 18.04.2024
Tilføjet 18.04.2024
A new test appears to be better than current options for diagnosing pathogens that cause meningitis, encephalitis, and other neurologic infections. Medscape Medical News
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Neonatal Elizabethkingia anophelis meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
B Ruben Brandsema, Ger-Jan Fleurke, Sigrid Rosema, Eke MW Schins, Jelte Helfferich and Erik Bathoorn
Eurosurveillance latest updates, 5.04.2024
Tilføjet 5.04.2024
Elizabethkingia anophelis is a multidrug-resistant pathogen causing high mortality and morbidity in adults with comorbidities and neonates. We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family’s residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.
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Timing the New Meningitis Shots Serogroup Top 5's
Medscape Infectious Diseases, 14.03.2024
Tilføjet 14.03.2024
Clinicians are evaluating optimal timing for vaccination now that the first pentavalent vaccine against all five major serogroups of meningococcal disease is available. Medscape Medical News
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Untargeted metagenomic sequencing identifies Toscana virus in patients with idiopathic meningitis, southern Spain, 2015 to 2019
Fabiana Gámbaro, Ana Belén Pérez, Matthieu Prot, Eduardo Agüera, Artem Baidaliuk, María Paz Sánchez-Seco, Luis Martínez-Martínez, Ana Vázquez, María Dolores Fernandez-Garcia and Etienne Simon-Loriere
Eurosurveillance latest updates, 10.11.2023
Tilføjet 10.11.2023
BackgroundVarious pathogens, including bacteria, fungi, parasites, and viruses can lead to meningitis. Among viruses causing meningitis, Toscana virus (TOSV), a phlebovirus, is transmitted through sandfly bites. TOSV infection may be suspected if patients with enterovirus- and herpesvirus-negative aseptic (non-bacterial) meningitis recall recent insect bites. Other epidemiological factors (season, rural area) may be considered. The broad range of possible meningitis aetiologies poses considerable diagnosis challenges. Untargeted metagenomic next-generation sequencing (mNGS) can potentially identify pathogens, which are not considered or detected in routine diagnostic panels. AimIn this retrospective, single-centre observational study, we investigated mNGS usefulness to understand the cause of meningitis when conventional approaches fail. MethodsCerebrospinal fluid (CSF) samples from patients hospitalised in southern Spain in 2015–2019 with aseptic meningitis and no aetiology found by conventional testing, were subjected to mNGS. Patients’ demographic characteristics had been recorded and physicians had asked them about recent insect bites. Obtained viral genome sequences were phylogenetically analysed. ResultsAmong 23 idiopathic cases, TOSV was identified in eight (all male; median age: 39 years, range: 15–78 years). Five cases lived in an urban setting, three occurred in autumn and only one recalled insect bites. Phylogenetic analysis of TOSV segment sequences supported one intra-genotype reassortment event. ConclusionsOur study highlights the usefulness of mNGS for identifying viral pathogens directly in CSF. In southern Spain, TOSV should be considered regardless of recalling of insect bites or other epidemiological criteria. Detection of a disease-associated reassortant TOSV emphasises the importance of monitoring the spread and evolution of phleboviruses in Mediterranean countries.
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