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47 ud af 47 tidsskrifter valgt, søgeord (meningitis) valgt, emner højest 180 dage gamle, sorteret efter nyeste først.
66 emner vises.
Snoek, L., van Kassel, M. N., Koelman, D. L. H., van der Ende, A., van Sorge, N. M., Brouwer, M. C., van de Beek, D., Bijlsma, M. W.
BMJ Open, 30.12.2023
Tilføjet 30.12.2023
ObjectivesThis study aimed to estimate the recurrence rate of culture-positive bacterial meningitis in children in the Netherlands. DesignNationwide surveillance study, using the database of the Netherlands Reference Laboratory for Bacterial Meningitis to identify patients with culture-positive bacterial meningitis during childhood. SettingThe study was based in the Netherlands. ParticipantsA total of 9731 children with a first bacterial meningitis episode between 1 July 1987 and 30 June 2019 were identified. Primary and secondary outcome measuresRecurrence was defined as a subsequent episode >28 days, or caused by a different pathogen. Annual incidence and incidence rate ratios (IRRs) comparing the periods 1988–2003 and 2004–2019 were calculated. Predictors of recurrent meningitis were assessed using Cox proportional hazards regression. ResultsSixty-three (0.6%) of the 9731 children with a first bacterial meningitis episode contracted recurrent meningitis. Neisseria meningitidis was the leading pathogen for first meningitis episodes (52%) and Streptococcus pneumoniae for recurrent episodes (52%). The median annual incidence of first episodes per 100 000 children decreased from 11.81 (IQR 11.26–17.60) in 1988–2003 to 2.60 (IQR 2.37–4.07) in 2004–2019 (IRR 0.25, 95% CI 0.23 to 0.26). The incidence of recurrences did not change: 0.06 (IQR 0.02–0.11) in 1988–2003 to 0.03 (IQR 0.00–0.06) in 2004–2019 (IRR 0.65, 95% CI 0.39 to 1.1). Age above 5 years (OR 3.6 (95% CI 1.5 to 8.3)) and a first episode due to Escherichia coli (OR 25.7 (95% CI 7.2 to 92.0)) were associated with higher risks of recurrence. ConclusionThe recurrence rate of childhood bacterial meningitis in the Netherlands was 0.6%. While the incidence rate of first episodes decreased substantially, this was not the case for recurrent episodes. Older age and a first episode due to E. coli were associated with higher recurrence risks.
Læs mere Tjek på PubMedHongqin XuHongyan LiHailong YouPeng ZhangNan LiNan JiangYang CaoLing QinGuixiang QinHongbo QuHeyuan WangBo ZouXia HeDan LiHuazhong ZhaoGang HuangYang LiHefeng ZhangLiping ZhuHongmei QiaoHongjun LiShurong LiuLina GuGuidong YinYe HuSongbai XuWeiying GuoNanya WangChaoying LiuPujun GaoJie CaoYang ZhengKaiyu ZhangYang WangHui ChenJian ZhangDongmei MuJunqi Niua Department of Hepatology, Center of Infectious Diseases and Pathogen Biology, The First Hospital of Jilin University, Changchun, People’s Republic of Chinab Nursing Department, The First Hospital of Jilin University, Changchun, People’s Republic of Chinac Department of Pediatrics, First Hospital of Jilin University, Changchun, People’s Republic of Chinad Department of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, The First Hospital of Jilin University, Changchun, People’s Republic of Chinae Intensive Care Unit, The First Hospital of Jilin University, Changchun, People’s Republic of Chinaf Department of Infectious Diseases, Changchun Infectious Disease Hospital, Changchun, People’s Republic of Chinag Department of obstetrics and gynecology, Hepatobiliary Hospital of Jilin, Changchun, People’s Republic of Chinah Department of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun, People’s Republic of Chinai Center of Tubercular Meningitis, Changchun Infectious Disease Hospital, Changchun, People’s Republic of Chinaj Department of Medical Affairs, Hepatobiliary Hospital of Jilin, Changchun, People’s Republic of Chinak Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, People’s Republic of Chinal Department of Medical Affairs, Changchun Infectious Disease Hospital, Changchun, People’s Republic of Chinam Nursing Department, Hepatobiliary Hospital of Jilin, Changchun, People’s Republic of Chinan Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, People’s Republic of Chinao Department of Integrated Traditional and Western Medicine, Changchun Infectious Disease Hospital, Changchun, People’s Republic of Chinap Center of Information and Statistics, Hepatobiliary Hospital of Jilin, Changchun, People’s Republic of Chinaq Department of Integrated Traditional and Western Medicine, Hepatobiliary Hospital of Jilin, Changchun, People’s Republic of Chinar Department of pediatric respiratory medicine, The First Hospital of Jilin University, Changchun, People’s Republic of Chinas The Fifth treatment area, Changchun Infectious Disease Hospital, Changchun, People’s Republic of Chinat Department of Hepatology, Hepatobiliary Hospital of Jilin, Changchun, People’s Republic of Chinau Department of cerebral surgery, Changchun Infectious Disease Hospital, Changchun, People’s Republic of Chinav Department of Neurosurgery, the First Hospital of Jilin University, Changchun, People’s Republic of Chinaw Cancer Center, The First Hospital of Jilin University, Changchun, People’s Republic of Chinax Department of Neology, The First Hospital of Jilin University, Changchun, People’s Republic of Chinay Department of Clinical Epidemiology, The First Hospital of Jilin University, Changchun, People’s Republic of China
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
BMC Infectious Diseases, 28.12.2023
Tilføjet 28.12.2023
Abstract Background The differential diagnosis between tuberculous meningitis (TBM) and viral meningitis (VM) or bacterial meningitis (BM) remains challenging in clinical practice, particularly in resource-limited settings. This study aimed to establish a diagnostic model that can accurately and early distinguish TBM from both VM and BM in adults based on simple clinical and laboratory parameters. Methods Patients diagnosed with TBM or non-TBM (VM or BM) between January 2012 and October 2021 were retrospectively enrolled from the General Hospital (derivation cohort) and Branch Hospital (validation cohort) of Ningxia Medical University. Demographic characteristics, clinical symptoms, concomitant diseases, and cerebrospinal fluid (CSF) parameters were collated. Univariable logistic analysis was performed in the derivation cohort to identify significant variables (P 5 days, weight loss > 5% of the original weight within 6 months, CSF lymphocyte ratio > 50%, CSF glucose concentration
Læs mere Tjek på PubMedBMC Infectious Diseases, 22.12.2023
Tilføjet 22.12.2023
Abstract Background The differential diagnosis between tuberculous meningitis (TBM) and viral meningitis (VM) or bacterial meningitis (BM) remains challenging in clinical practice, particularly in resource-limited settings. This study aimed to establish a diagnostic model that can accurately and early distinguish TBM from both VM and BM in adults based on simple clinical and laboratory parameters. Methods Patients diagnosed with TBM or non-TBM (VM or BM) between January 2012 and October 2021 were retrospectively enrolled from the General Hospital (derivation cohort) and Branch Hospital (validation cohort) of Ningxia Medical University. Demographic characteristics, clinical symptoms, concomitant diseases, and cerebrospinal fluid (CSF) parameters were collated. Univariable logistic analysis was performed in the derivation cohort to identify significant variables (P 5 days, weight loss > 5% of the original weight within 6 months, CSF lymphocyte ratio > 50%, CSF glucose concentration
Læs mere Tjek på PubMedBMC Infectious Diseases, 8.12.2023
Tilføjet 8.12.2023
Abstract Purpose To examine the clinical characteristics of adult patients with community-acquired spontaneous bacterial meningitis (CASBM) with a fulminant clinical course. Materials and methods The clinical features and therapeutic outcomes of 127 adult CASBM patients were analyzed. The patients were divided into two groups as those with and without a fulminant clinical course. Fulminant clinical course was defined as meningitis presenting initially with marked consciousness disturbance (Glasgow Coma Scale score
Læs mere Tjek på PubMedBMC Infectious Diseases, 8.12.2023
Tilføjet 8.12.2023
Abstract Purpose To examine the clinical characteristics of adult patients with community-acquired spontaneous bacterial meningitis (CASBM) with a fulminant clinical course. Materials and methods The clinical features and therapeutic outcomes of 127 adult CASBM patients were analyzed. The patients were divided into two groups as those with and without a fulminant clinical course. Fulminant clinical course was defined as meningitis presenting initially with marked consciousness disturbance (Glasgow Coma Scale score
Læs mere Tjek på PubMedPelle T. Petersen, Jacob Bodilsen, Micha P. G. Jepsen, Lykke Larsen, Merete Storgaard, Jannik Helweg‐Larsen, Lothar Wiese, Birgitte R. Hansen, Hans R. Lüttichau, Christian Ø. Andersen, Henrik Nielsen, Christian T. Brandt, The Danish Study Group of Infections of the Brain (DASGIB)
Journal of Medical Virology, 7.12.2023
Tilføjet 7.12.2023
Thomas C. McHaleDavid R. BoulwareJohn KasibanteKenneth SsebambuliddeCaleb P. SkipperMahsa Abassi1Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA2Infectious Diseases Institute, Makerere University, Kampala, Uganda, Graeme N. Forrest
Clinical Microbiology Reviews, 29.11.2023
Tilføjet 29.11.2023
Faye LanniRosleine Antilus SainteMark Hansen,Paul ParigiFirat KayaKatherine LoMauroBernard SiowRobert J. WilkinsonSean WassermanBrendan K. PodellMartin GengenbacherVéronique Dartois1Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA2The Francis Crick Institute, London, United Kingdom3Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa4Department of Medicine, University of Cape Town, Cape Town, South Africa5Department of Infectious Diseases, Imperial College London, London, United Kingdom6Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA7Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA, Jared A. Silverman
Antimicrobial Agents And Chemotherapy, 27.11.2023
Tilføjet 27.11.2023
Clinical Infectious Diseases, 18.11.2023
Tilføjet 18.11.2023
Strange are the opportunities that presented themselves and where the path led during the coronavirus disease 2019 (COVID-19) pandemic. It all began when I was at a National Institutes of Health (NIH) study section on 5–6 March 2020 in Washington, DC, expecting to fly to Boston for the Conference on Retroviruses and Opportunistic Infections (CROI) when a Friday email announced the cancellation of in-person attendance at the conference (wisely). I had been looking forward to CROI, having worked for weeks to get visa appointments for two Ugandan scientists to travel to CROI to present their cryptococcal meningitis abstracts. My team makes an effort always to present cryptococcal abstracts at CROI so that people do not forget that opportunistic infections still exist worldwide. In March 2020, we were excited to have just launched a phase 2 trial to test oral amphotericin B formulation for cryptococcal meningitis.
Læs mere Tjek på PubMedFaye LanniRosleine Antilus SainteMark Hansen,Paul ParigiFirat KayaKatherine LoMauroBernard SiowRobert J. WilkinsonSean WassermanBrendan K. PodellMartin GengenbacherVéronique Dartois1Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA2The Francis Crick Institute, London, United Kingdom3Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa4Department of Medicine, University of Cape Town, Cape Town, South Africa5Department of Infectious Diseases, Imperial College London, London, United Kingdom6Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA7Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA, Jared A. Silverman
Antimicrobial Agents And Chemotherapy, 15.11.2023
Tilføjet 15.11.2023
BMC Infectious Diseases, 11.11.2023
Tilføjet 11.11.2023
Abstract Background Leptospirosis is a zoonotic disease that afflicts both humans and animals. It progresses from flu-like symptoms to more severe hepatic and renal failure, and may also lead to aseptic meningitis. Individuals with autoimmune diseases (ADs) are potentially more susceptible to Leptospirosis. Thus far, limited data has documented the association between Leptospirosis and autoimmune disorders. Case presentation The patient had a definitive pathological diagnosis of Sjögren’s syndrome (SS). Due to recurrent headaches, the patient sought consultation with a neurologist. Lumbar puncture revealed elevated white blood cells and protein levels in the cerebrospinal fluid, along with decreased glucose. Tuberculous meningitis was suspected. Radiographic imaging exhibited meningeal enhancement, ventricular enlargement, and hydrocephalus. The patient commenced treatment with anti-tuberculosis therapy and corticosteroids. Subsequently, high-throughput sequencing (HTS) of cerebrospinal fluid identified the presence of Leptospira interrogans. The patient was ultimately diagnosed with Leptospiral meningitis, and underwent antimicrobial and immunosuppressive therapy, resulting in stabilization of the condition and gradual symptom recovery. Conclusions The case highlights the challenges in diagnosing and managing leptospirosis-related meningitis in the presence of ADs and emphasizes the importance of utilizing HTS for accurate pathogen detection. The potential correlation between leptospirosis and SS warrants further investigation, as does the need for multidisciplinary involvement in treatment strategies for such complex cases.
Læs mere Tjek på PubMedBMC Infectious Diseases, 9.11.2023
Tilføjet 9.11.2023
Abstract Background Leptospirosis is a zoonotic disease that afflicts both humans and animals. It progresses from flu-like symptoms to more severe hepatic and renal failure, and may also lead to aseptic meningitis. Individuals with autoimmune diseases (ADs) are potentially more susceptible to Leptospirosis. Thus far, limited data has documented the association between Leptospirosis and autoimmune disorders. Case presentation The patient had a definitive pathological diagnosis of Sjögren’s syndrome (SS). Due to recurrent headaches, the patient sought consultation with a neurologist. Lumbar puncture revealed elevated white blood cells and protein levels in the cerebrospinal fluid, along with decreased glucose. Tuberculous meningitis was suspected. Radiographic imaging exhibited meningeal enhancement, ventricular enlargement, and hydrocephalus. The patient commenced treatment with anti-tuberculosis therapy and corticosteroids. Subsequently, high-throughput sequencing (HTS) of cerebrospinal fluid identified the presence of Leptospira interrogans. The patient was ultimately diagnosed with Leptospiral meningitis, and underwent antimicrobial and immunosuppressive therapy, resulting in stabilization of the condition and gradual symptom recovery. Conclusions The case highlights the challenges in diagnosing and managing leptospirosis-related meningitis in the presence of ADs and emphasizes the importance of utilizing HTS for accurate pathogen detection. The potential correlation between leptospirosis and SS warrants further investigation, as does the need for multidisciplinary involvement in treatment strategies for such complex cases.
Læs mere Tjek på PubMedBMC Infectious Diseases, 9.11.2023
Tilføjet 9.11.2023
Abstract Background Leptospirosis is a zoonotic disease that afflicts both humans and animals. It progresses from flu-like symptoms to more severe hepatic and renal failure, and may also lead to aseptic meningitis. Individuals with autoimmune diseases (ADs) are potentially more susceptible to Leptospirosis. Thus far, limited data has documented the association between Leptospirosis and autoimmune disorders. Case presentation The patient had a definitive pathological diagnosis of Sjögren’s syndrome (SS). Due to recurrent headaches, the patient sought consultation with a neurologist. Lumbar puncture revealed elevated white blood cells and protein levels in the cerebrospinal fluid, along with decreased glucose. Tuberculous meningitis was suspected. Radiographic imaging exhibited meningeal enhancement, ventricular enlargement, and hydrocephalus. The patient commenced treatment with anti-tuberculosis therapy and corticosteroids. Subsequently, high-throughput sequencing (HTS) of cerebrospinal fluid identified the presence of Leptospira interrogans. The patient was ultimately diagnosed with Leptospiral meningitis, and underwent antimicrobial and immunosuppressive therapy, resulting in stabilization of the condition and gradual symptom recovery. Conclusions The case highlights the challenges in diagnosing and managing leptospirosis-related meningitis in the presence of ADs and emphasizes the importance of utilizing HTS for accurate pathogen detection. The potential correlation between leptospirosis and SS warrants further investigation, as does the need for multidisciplinary involvement in treatment strategies for such complex cases.
Læs mere Tjek på PubMedInfection, 5.11.2023
Tilføjet 5.11.2023
Abstract Purpose To describe clinical features and outcomes of viral lumbosacral radiculitis (Elsberg syndrome). Methods Nationwide population-based cohort study of all adults hospitalised for viral lumbosacral radiculitis at departments of infectious diseases in Denmark from 2015 to 2020. Results Twenty-eight patients with viral lumbosacral radiculitis were included (mean annual incidence: 1.2/1,000,000 adults). The median age was 35 years (IQR 27–43), and 22/28 (79%) were female. All patients had urinary retention, with 17/28 (61%) needing a catheter. On admission, at least one sign or symptom of meningitis (headache, neck stiffness, photophobia/hyperacusis) was present in 18/22 (82%). Concurrent genital herpetic lesions were present in 11/24 (46%). The median cerebrospinal fluid leukocyte count was 153 cells/µL (IQR 31–514). Magnetic resonance imaging showed radiculitis/myelitis in 5/19 (26%). The microbiological diagnosis was herpes simplex virus type 2 in 19/28 (68%), varicella-zoster virus in 2/28 (7%), and unidentified in 7/28 (25%). Aciclovir/valaciclovir was administered in 27/28 (96%). At 30 days after discharge, 3/27 (11%) had persistent urinary retention with need of catheter. At 180 days after discharge, moderate disabilities (Glasgow Outcome Scale score of 4) were observed in 5/25 (20%). Conclusions Urinary retention resolved within weeks in most patients with viral lumbosacral radiculitis, but moderate disabilities according to the Glasgow Outcome Scale were common at the end of follow-up.
Læs mere Tjek på PubMedInfection, 2.11.2023
Tilføjet 2.11.2023
Abstract Purpose To describe clinical features and outcomes of viral lumbosacral radiculitis (Elsberg syndrome). Methods Nationwide population-based cohort study of all adults hospitalised for viral lumbosacral radiculitis at departments of infectious diseases in Denmark from 2015 to 2020. Results Twenty-eight patients with viral lumbosacral radiculitis were included (mean annual incidence: 1.2/1,000,000 adults). The median age was 35 years (IQR 27–43), and 22/28 (79%) were female. All patients had urinary retention, with 17/28 (61%) needing a catheter. On admission, at least one sign or symptom of meningitis (headache, neck stiffness, photophobia/hyperacusis) was present in 18/22 (82%). Concurrent genital herpetic lesions were present in 11/24 (46%). The median cerebrospinal fluid leukocyte count was 153 cells/µL (IQR 31–514). Magnetic resonance imaging showed radiculitis/myelitis in 5/19 (26%). The microbiological diagnosis was herpes simplex virus type 2 in 19/28 (68%), varicella-zoster virus in 2/28 (7%), and unidentified in 7/28 (25%). Aciclovir/valaciclovir was administered in 27/28 (96%). At 30 days after discharge, 3/27 (11%) had persistent urinary retention with need of catheter. At 180 days after discharge, moderate disabilities (Glasgow Outcome Scale score of 4) were observed in 5/25 (20%). Conclusions Urinary retention resolved within weeks in most patients with viral lumbosacral radiculitis, but moderate disabilities according to the Glasgow Outcome Scale were common at the end of follow-up.
Læs mere Tjek på PubMed