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Hong-Xing Pan, Ling-Xian Qiu, Qi Liang, Zhen Chen, Ming-Lei Zhang, Sheng Liu, Guo-Hua Zhong, Kong-Xin Zhu, Meng-Jun Liao, Jia-Lei Hu, Jia-Xue Li, Jin-Bo Xu, Yong Fan, Yue Huang, Ying-Ying Su, Shou-Jie Huang, Wei Wang, Jin-Le Han, Ji-Zong Jia, Hua Zhu, Tong Cheng, Xiang-Zhong Ye, Chang-Gui Li, Ting Wu, Feng-Cai Zhu, Jun Zhang, Ning-Shao Xia
Lancet Infectious Diseases, 11.04.2024
Tilføjet 11.04.2024
The three dose groups of the candidate v7D vaccine exhibit similar humoral immunogenicity to the vOka vaccine and are well tolerated. These findings encourage further investigations on two-dose vaccination schedules, efficacy, and the potential safety benefit of v7D vaccine in the future.
Læs mere Tjek på PubMedChongqiang HuangLiangzheng YuYi XuJiamo HuangYibin QinXuan GuoYongfang ZengYifeng QinKang OuyangZuzhang WeiWeijian HuangAdolfo García-SastreYing Chena Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People’s Republic of Chinab Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People’s Republic of Chinac Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, People’s Republic of Chinad Guangxi Institute of Veterinary Medicine, Nanning, People’s Republic of Chinae Guangxi Nongken Yongxin Animal Husbandry Group Co. Ltd., Nanning, People’s Republic of Chinaf Nanning Zhufulai Animal Health Management Co. Ltd., Nanning, People’s Republic of Chinag Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USAh Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAi Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Emerg Microbes Infect, 10.04.2024
Tilføjet 10.04.2024
Vicente Friaza, Pilar Rojas, Carmen de la Horra, Elisa García, Rubén Morilla, Antonio Pavón, Yaxsier de Armas, Antonio J. Vallejo-Vaz, Rocío Salsoso, Francisco J. Medrano, Enrique J. Calderón
PLoS One Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
by Vicente Friaza, Pilar Rojas, Carmen de la Horra, Elisa García, Rubén Morilla, Antonio Pavón, Yaxsier de Armas, Antonio J. Vallejo-Vaz, Rocío Salsoso, Francisco J. Medrano, Enrique J. Calderón Background Pneumocytis jirovecii infection in preterm newborns has recently been associated with neonatal respiratory distress syndrome and bronchopulmonary dysplasia. Changes in the bacterial microbiota of the airways have also been described in infants with bronchopulmonary dysplasia. However, until now there has been no information on the airway mycobiota in newborns. The purpose of this study was to describe the airway mycobiota in term and preterm newborns and its possible association with respiratory distress syndrome. Methods Twenty-six matched preterm newborns with and without respiratory distress syndrome were studied, as well as 13 term babies. The identification of the fungal microbiota was carried out using molecular procedures in aspirated nasal samples at birth. Results The ascomycota phylum was identified in 89.7% of newborns, while the basidiomycota phylum was found in 33.3%. Cladosporium was the predominant genus in both term and preterm infants 38.4% vs. 73% without statistical differences. Candida sake and Pneumocystis jirovecii were only found in preterm infants, suggesting a potential relationship with the risk of prematurity. Conclusions This is the first report to describe the fungal microbiota of the airways in term and preterm infants with and without respiratory distress syndrome. Although no differences have been observed, the number of cases analyzed could be small to obtain conclusive results, and more studies are needed to understand the role of the fungal microbiota of the airways in neonatal respiratory pathology.
Læs mere Tjek på PubMedBing Li, Chao Wen, Shenglan Yang, Mingzhao Ma, Jie Cheng, Wenxin Li
PLoS One Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
by Bing Li, Chao Wen, Shenglan Yang, Mingzhao Ma, Jie Cheng, Wenxin Li This paper focuses on optimizing the management of delayed trains in operational scenarios by scientifically categorizing train delay levels. It employs static and dynamic models grounded in real-world train delay data from high-speed railways. This classification aids dispatchers in swiftly identifying and predicting delay extents, thus enhancing mitigation strategies’ efficiency. Key indicators, encompassing initial delay duration, station impacts, average station delay, delayed trains’ cascading effects, and average delay per affected train, inform the classification. Applying the K-means clustering algorithm to standardized delay indicators yields an optimized categorization of delayed trains into four levels, reflecting varying risk levels. This static classification offers a comprehensive overview of delay dynamics. Furthermore, utilizing Markov chains, the study delves into sequential dynamic analyses, accounting for China’s railway context and specifically addressing fluctuations during the Spring Festival travel rush. This research, combining static and dynamic approaches, provides valuable insights for bolstering railway operational efficiency and resilience amidst diverse delay scenarios.
Læs mere Tjek på PubMedMulugeta Samuel Demissie, Negash Hailu Legesse, Aderajew Adgo Tesema
PLoS One Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
by Mulugeta Samuel Demissie, Negash Hailu Legesse, Aderajew Adgo Tesema The continuous accumulation of waste, particularly from industries, often ends up in landfills. However, this waste can be transformed into a valuable resource through innovative methods. This process not only reduces environmental pollution but also generates additional useful products. This study aims to screen novel high-efficiency cellulose-degrading bacteria from cow dung, forest soil, brewery waste, and agro-industrial waste in the Debre Berhan area for the treatment of cellulose-rich agricultural waste. The serial dilution and pour plate method was used to screen for cellulolytic bacteria and further characterized using morphological and biochemical methods. From eleven isolates cow dung 1 (CD1), cow dung 6 (CD6) and cow dung (CD3) which produced the largest cellulolytic index (3.1, 2.9 and 2.87) were selected. Samples from forest soil, and spent grain didn’t form a zone of clearance, and effluent treatment and industrial waste (IW9) shows the smallest cellulolytic index. Three potential isolates were then tested for cellulolytic activity, with cow dung 1 (CD1) displaying promising cellulase activity. These bacterial isolates were then identified as Bacillus species, which were isolated from cow dung 1 (CD1) with maximum cellulase production. Cow dung waste is a rich source of cellulase-producing bacteria, which can be valuable and innovative enzymes for converting lignocellulosic waste.
Læs mere Tjek på PubMedJiayin Ou, Jiayu Li, Yang Liu, Xiaohong Su, Wanchun Li, Xiaojun Zheng, Lang Zhang, Jing Chen, Huafeng Pan
PLoS One Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
by Jiayin Ou, Jiayu Li, Yang Liu, Xiaohong Su, Wanchun Li, Xiaojun Zheng, Lang Zhang, Jing Chen, Huafeng Pan Objectives To systematically assess the quality of clinical practice guidelines (CPGs) for Helicobacter pylori (HP) infection and identify gaps that limit their development. Study design and setting CPGs for HP infection were systematically collected from PubMed, Embase, the Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature, and six online guideline repositories. Three researchers independently used the AGREE Ⅱ tool to evaluate the methodological quality of the eligible CPGs. In addition, the reporting and recommendation qualities were appraised by using the RIGHT and AGREE-REX tools, respectively. The distribution of the level of evidence and strength of recommendation among evidence-based CPGs was determined. Results A total of 7,019 records were identified, and 24 CPGs met the eligibility criteria. Of the eligible CPGs, 19 were evidence-based and 5 were consensus-based. The mean overall rating score of AGREE II was 50.7% (SD = 17.2%). Among six domains, the highest mean score was for scope and purpose (74.4%, SD = 17.7%) and the lowest mean score was for applicability (24.3%, SD = 8.9). Only three of 24 CPGs were high-quality. The mean overall score of recommendation quality was 35.5% (SD = 12.2%), and the mean scores in each domain of AGREE-REX and RIGHT were all ≤ 60%, with values and preferences scoring the lowest (16.6%, SD = 11.9%). A total of 505 recommendations were identified. Strong recommendations accounted for 64.1%, and only 34.3% of strong recommendations were based on high-quality evidence. Conclusion The overall quality of CPGs for HP infection is poor, and CPG developers tend to neglect some domains, resulting in a wide variability in the quality of the CPGs. Additionally, CPGs for HP infection lack sufficient high-quality evidence, and the grading of recommendation strength should be based on the quality of evidence. The CPGs for HP infection have much room for improvement and further researches are required to minimize the evidence gap.
Læs mere Tjek på PubMedAbid Hussain, Asmatullah Kakar, Mahrukh Naseem, Kashif Kamran, Zafar Ullah, Shehla Shehla, Muhammad Kashif Obaid, Nazeer Ahmed, Qaiser Khan, Iram Liaqat
PLoS One Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
by Abid Hussain, Asmatullah Kakar, Mahrukh Naseem, Kashif Kamran, Zafar Ullah, Shehla Shehla, Muhammad Kashif Obaid, Nazeer Ahmed, Qaiser Khan, Iram Liaqat The order Hymenoptera holds great significance for humans, particularly in tropical and subtropical regions, due to its role as a pollinator of wild and cultivated flowering plants, parasites of destructive insects and honey producers. Despite this importance, limited attention has been given to the genetic diversity and molecular identification of Hymenopteran insects in most protected areas. This study provides insights into the first DNA barcode of Hymenopteran insects collected from Hazarganji Chiltan National Park (HCNP) and contributes to the global reference library of DNA barcodes. A total of 784 insect specimens were collected using Malaise traps, out of which 538 (68.62%) specimens were morphologically identified as Hymenopteran insects. The highest abundance of species of Hymenoptera (133/538, 24.72%) was observed during August and least in November (16/538, 2.97%). Genomic DNA extraction was performed individually from 90/538 (16.73%) morphologically identified specimens using the standard phenol-chloroform method, which were subjected separately to the PCR for their molecular confirmation via the amplification of cytochrome c oxidase subunit 1 (cox1) gene. The BLAST analyses of obtained sequences showed 91.64% to 100% identities with related sequences and clustered phylogenetically with their corresponding sequences that were reported from Australia, Bulgaria, Canada, Finland, Germany, India, Israel, and Pakistan. Additionally, total of 13 barcode index numbers (BINs) were assigned by Barcode of Life Data Systems (BOLD), out of which 12 were un-unique and one was unique (BOLD: AEU1239) which was assigned for Anthidium punctatum. This indicates the potential geographical variation of Hymenopteran population in HCNP. Further comprehensive studies are needed to molecularly confirm the existing insect species in HCNP and evaluate their impacts on the environment, both as beneficial (for example, pollination, honey producers and natural enemies) and detrimental (for example, venomous stings, crop damage, and pathogens transmission).
Læs mere Tjek på PubMedBryan K. Lynn, Patrick De Leenheer, Martin Schuster
PLoS One Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
by Bryan K. Lynn, Patrick De Leenheer, Martin Schuster Cooperation via shared public goods is ubiquitous in nature, however, noncontributing social cheaters can exploit the public goods provided by cooperating individuals to gain a fitness advantage. Theory predicts that this dynamic can cause a Tragedy of the Commons, and in particular, a ‘Collapsing’ Tragedy defined as the extinction of the entire population if the public good is essential. However, there is little empirical evidence of the Collapsing Tragedy in evolutionary biology. Here, we experimentally demonstrate this outcome in a microbial model system, the public good-producing bacterium Pseudomonas aeruginosa grown in a continuous-culture chemostat. In a growth medium that requires extracellular protein digestion, we find that P. aeruginosa populations maintain a high density when entirely composed of cooperating, protease-producing cells but completely collapse when non-producing cheater cells are introduced. We formulate a mechanistic mathematical model that recapitulates experimental observations and suggests key parameters, such as the dilution rate and the cost of public good production, that define the stability of cooperative behavior. We combine model prediction with experimental validation to explain striking differences in the long-term cheater trajectories of replicate cocultures through mutational events that increase cheater fitness. Taken together, our integrated empirical and theoretical approach validates and parametrizes the Collapsing Tragedy in a microbial population, and provides a quantitative, mechanistic framework for generating testable predictions of social behavior.
Læs mere Tjek på PubMedMarta Garcia-Lopez, Thibaut Lurier, Marie Bouilloud, Julien Pradel, Caroline Tatard, Diana Sepulveda, Gwendoline Anfray, Julie Dussert, Pascale Bourhy, Nathalie Charbonnel, Zouheira Djelouadji
PLoS One Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
by Marta Garcia-Lopez, Thibaut Lurier, Marie Bouilloud, Julien Pradel, Caroline Tatard, Diana Sepulveda, Gwendoline Anfray, Julie Dussert, Pascale Bourhy, Nathalie Charbonnel, Zouheira Djelouadji Rodents are recognized as the main reservoirs of Leptospira spp. Rats, in particular, serve as hosts for the widely predominant Leptospira interrogans serovar Icterohaemorrhagiae, found worldwide. Several studies have shown the importance of other reservoirs, such as mice or hedgehogs, which harbor other leptospires’ serovars. Nevertheless, our knowledge of circulating Leptospira spp. in reservoirs other than rats remains limited. In this context, we proposed an eco-health approach to assess the health hazard associated with leptospires in urban green spaces, where contacts between human/small mammals and domestic animals are likely. We studied the prevalence, the diversity of circulating strains, and epidemiology of pathogenic Leptospira species in small terrestrial mammal communities (rodents and shrews), between 2020–2022, in two parks in Lyon metropolis, France. Our study showed a significant carriage of Leptospira spp. in small terrestrial mammals in these parks and unveiled a global prevalence rate of 11.4%. Significant variations of prevalence were observed among the small mammal species (from 0 to 26.1%), with Rattus norvegicus exhibiting the highest infection levels (26.1%). We also observed strong spatio-temporal variations in Leptospira spp. circulation in its reservoirs. Prevalence seems to be higher in the peri-urban park and in autumn in 2021 and 2022. This is potentially due to differences in landscape, abiotic conditions and small mammal communities’ composition. Our study suggests an important public health relevance of rats and in a lesser extent of other rodents (Apodemus spp., Clethrionomys glareolus and Mus musculus) as reservoirs of L. interrogans, with rodent species carrying specific serogroups/serovars. We also emphasize the potential hazard associated between the shrew Crocidura russula and L. kirschneri. Altogether, these results improve our knowledge about the prevalence of leptospirosis in an urban environment, which is an essential prerequisite for the implementation of prevention of associated risks.
Læs mere Tjek på PubMedMalaria Journal, 10.04.2024
Tilføjet 10.04.2024
Abstract Background Artemisinin-based combination therapy (ACT) has been a major contributor to the substantial reductions in global malaria morbidity and mortality over the last decade. In Tanzania, artemether-lumefantrine (AL) was introduced as the first-line treatment for uncomplicated Plasmodium falciparum malaria in 2006. The World Health Organization (WHO) recommends regular assessment and monitoring of the efficacy of the first-line treatment, specifically considering that artemisinin resistance has been confirmed in the Greater Mekong sub-region. This study\'s main aim was to assess the efficacy and safety of AL for treating uncomplicated P. falciparum malaria in Tanzania. Methods This was a single-arm prospective antimalarial drug efficacy trial conducted in four of the eight National Malaria Control Programme (NMCP) sentinel sites in 2019. The trial was carried out in outpatient health facilities in Karume-Mwanza region, Ipinda-Mbeya region, Simbo-Tabora region, and Nagaga-Mtwara region. Children aged six months to 10 years with microscopy confirmed uncomplicated P. falciparum malaria who met the inclusion criteria were recruited based on the WHO protocol. The children received AL (a 6-dose regimen of AL twice daily for three days). Clinical and parasitological parameters were monitored during follow-up over 28 days to evaluate drug efficacy. Results A total of 628 children were screened for uncomplicated malaria, and 349 (55.6%) were enrolled between May and September 2019. Of the enrolled children, 343 (98.3%) completed the 28-day follow-up or attained the treatment outcomes. There were no early treatment failures; recurrent infections during follow-up were common at two sites (Karume 29.5%; Simbo 18.2%). PCR-corrected adequate clinical and parasitological response (ACPR) by survival analysis to AL on day 28 of follow-up varied from 97.7% at Karume to 100% at Ipinda and Nagaga sites. The commonly reported adverse events were cough, skin pallor, and abdominal pain. The drug was well tolerated, and no serious adverse event was reported. Conclusion This study showed that AL had adequate efficacy and safety for the treatment of uncomplicated falciparum malaria in Tanzania in 2019. The high recurrent infections were mainly due to new infections, highlighting the potential role of introducing alternative artemisinin-based combinations that offer improved post-treatment prophylaxis, such as artesunate-amodiaquine (ASAQ).
Læs mere Tjek på PubMedMalaria Journal, 10.04.2024
Tilføjet 10.04.2024
Abstract Background Ghana is among the top 10 highest malaria burden countries, with about 20,000 children dying annually, 25% of which were under five years. This study aimed to produce interactive web-based disease spatial maps and identify the high-burden malaria districts in Ghana. Methods The study used 2016–2021 data extracted from the routine health service nationally representative and comprehensive District Health Information Management System II (DHIMS2) implemented by the Ghana Health Service. Bayesian geospatial modelling and interactive web-based spatial disease mapping methods were employed to quantify spatial variations and clustering in malaria risk across 260 districts. For each district, the study simultaneously mapped the observed malaria counts, district name, standardized incidence rate, and predicted relative risk and their associated standard errors using interactive web-based visualization methods. Results A total of 32,659,240 malaria cases were reported among children
Læs mere Tjek på PubMedImmunity, 10.04.2024
Tilføjet 10.04.2024
Publication date: 9 April 2024 Source: Immunity, Volume 57, Issue 4 Author(s): Ed C. Lavelle, Craig P. McEntee
Læs mere Tjek på PubMedImmunity, 10.04.2024
Tilføjet 10.04.2024
Publication date: 9 April 2024 Source: Immunity, Volume 57, Issue 4 Author(s): Ming Ma, Wei Jiang, Rongbin Zhou
Læs mere Tjek på PubMedInfectious Disease Modelling, 10.04.2024
Tilføjet 10.04.2024
Publication date: Available online 9 April 2024 Source: Infectious Disease Modelling Author(s): Jacques Ndé Kengne, Calvin Tadmon
Læs mere Tjek på PubMedInternational Journal for Parasitology, 10.04.2024
Tilføjet 10.04.2024
Publication date: Available online 10 April 2024 Source: International Journal for Parasitology Author(s): Mengshi Yu, Yongfang Yao, Xin Li, Aoxing Su, Meng Xie, Ying Xiong, Shengzhi Yang, Qingyong Ni, Hongtao Xiao, Huailiang Xu
Læs mere Tjek på PubMedInternational Journal for Parasitology, 10.04.2024
Tilføjet 10.04.2024
Publication date: Available online 10 April 2024 Source: International Journal for Parasitology Author(s): Ivan G. Horak, Joop Boomker, Vasily I. Grabovsky, Irina S. Khokhlova, Kerstin Junker, Juliana P. Sanchez, M. Fernanda López Berrizbeitia, Boris R. Krasnov
Læs mere Tjek på PubMedAndrew S. BrayM. Ammar Zafar1Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA, Karen M. Ottemann
Infection and Immunity, 10.04.2024
Tilføjet 10.04.2024
Infection, 10.04.2024
Tilføjet 10.04.2024
Abstract Purpose The prevalence of obesity is an escalating concern in modern populations, predominantly attributed to the widespread adoption of sedentary lifestyles observed globally. Extensive research has established a significant association between obesity and Helicobacter pylori (H. pylori). Nonetheless, a comprehensive assessment of the global prevalence of H. pylori among individuals with obesity remains undetermined. Methods A systematic search strategy was applied to PubMed, Scopus, and Web of Science. The resulting records were screened using the Rayyan online tool for the management of systematic reviews. Freeman–Tukey double arcsine transformation was used. Subgroup analyses (continent, regional classifications, developmental status, religion, global hemisphere, income, access to international waters, and H. pylori eradication) and multivariate meta-regression (latitude, longitude, male-to-all ratio, mean age, and body mass index) were done to estimate the effects of the moderators. Risk of bias assessment was done using JBI checklist for prevalence studies. Results A total of 472,511 individuals with obesity from 208 studies were included. The global estimation of H. pylori prevalence among individuals with obesity was 32.3% (95% CI 26.9%, 38.0%). South America had the highest prevalence. Based on the different classifications of countries, resource-rich, low-/middle-income, developing, and Islamic countries had the highest prevalence. Lower pooled prevalence was observed in the studies with adequate sample sizes (n ≥ 270). Conclusion The findings have the potential to influence future health policies for preventing and treating H. pylori infection. However, there is variability among the included studies, indicating the need for more population-based research.
Læs mere Tjek på PubMedInfection, 10.04.2024
Tilføjet 10.04.2024
Abstract Purpose Since an increase in the occurrence of native vertebral osteomyelitis (VO) is expected and reliable projections are missing, it is urgent to provide a reliable forecast model and make it a part of future health care considerations. Methods Comprehensive nationwide data provided by the Federal Statistical Office of Germany were used to forecast total numbers and incidence rates (IR) of VO as a function of age and gender until 2040. Projections were done using autoregressive integrated moving average model on historical data from 2005 to 2019 in relation to official population projections from 2020 to 2040. Results The IR of VO is expected to increase from 12.4 in 2019 to 21.5 per 100,000 inhabitants [95% CI 20.9–22.1] in 2040. The highest increase is predicted in patients over 75 years of age for both men and women leading to a steep increase in absolute numbers, which is fourfold higher compared to patients younger than 75 years. While the IR per age group will not increase any further after 2035, the subsequent increase is due to a higher number of individuals aged 75 years or older. Conclusions Our data suggest that increasing IR of VO will seriously challenge healthcare systems, particularly due to demographic change and increasing proportions of populations turning 75 years and older. With respect to globally fast aging populations, future health care policies need to address this burden by anticipating limitations in financial and human resources and developing high-level evidence-based guidelines for prevention and interdisciplinary treatment.
Læs mere Tjek på PubMedInfection, 10.04.2024
Tilføjet 10.04.2024
Abstract Purpose Diarrhea is an important cause of morbidity and mortality in immunocompromised patients. After including sapovirus to the viral gastroenteritis screening of our institution’s laboratory, we noticed an increase in sapovirus infections among kidney transplant recipients. Therefore, we assumed former gastrointestinal tract infections with unidentified pathogens could have been caused by sapovirus. To better understand the characteristics of a sapovirus infection in a high-risk group we initiated this study. Methods Over a period of 6 months, all transplant recipients with diarrhea and later identified viral/unknown pathogens were included. Kidney function, levels of immunosuppressants and c-reactive protein, acid–base balance, onset of symptoms and time of hospitalization were analyzed. Results Among 13 hospitalized kidney transplant recipients sapovirus was detected in four patients, while in the remaining nine, three were diagnosed with norovirus, one with cytomegalovirus, one with inflammatory bowel disease and in four patients no pathogen was identified. Even though statistically not significant, creatinine levels at admission tended to be higher in sapovirus patients (median: sapovirus: 3.3 mg/dl (1.3; 5.0), non-sapovirus: 2.5 mg/dl (1.1; 4.9), p = 0.710). Also, Tacrolimus levels showed the same trend (sapovirus: 13.6 ng/ml (12.9; 13.6), non-sapovirus: 7.1 ng/ml (2.6; 22.6), p = 0.279). On discharge creatinine levels improved equally in both groups (sapovirus: 1.7 mg/dl (1.4; 3.2), non-sapovirus: 2 mg/dl (1.0; 3.6), p = 0.825). Conclusion In high-risk patients, early symptomatic treatment remains crucial to protect the transplant`s function. In our cohort all patients recovered well. Larger cohorts and longer follow-up times are needed to detect the long-term consequences and a potential need for further research regarding specific treatment. Trial registration The study has been registered on DRKS (trialsearch.who.int), Reg. Nr. DRKS00033311 (December 28th 2023).
Læs mere Tjek på PubMedInfection, 10.04.2024
Tilføjet 10.04.2024
Abstract In the context of the evolving global health landscape shaped by the COVID-19 pandemic, tuberculosis (TB) is gaining renewed attention as a reemerging threat even in low-endemic countries. Immunological tests such as the tuberculin skin test (TST) and interferon-gamma release assay (IGRA) are pivotal in identifying tuberculosis infection (TBI). However, their inability to distinguish between past and ongoing infection poses a diagnostic challenge, possibly leading to the unnecessary treatment of a significant portion of the population with potential side effects. This review delves into the concept of incipient tuberculosis (ITB), a dynamic, presymptomatic stage characterized by heightened Mycobacterium tuberculosis complex (MTC) metabolic activity and replication that result in minimal radiological changes, signifying a transitional state between TBI and TB. Key focus areas include epidemiological factors, underlying pathogenesis, imaging findings, and the ongoing challenges in the identification of individuals with ITB through the development of new biomarkers and the use of whole-genome sequencing-based analyses to implement early treatment strategies.
Læs mere Tjek på PubMedInfection, 10.04.2024
Tilføjet 10.04.2024
Abstract Purpose Bronchoalveolar lavage is commonly used in clinical practice for unresolved pneumonia. However, bronchoalveolar lavage is not suitable for all patients as it is an invasive procedure and can worsen oxygenation. The diagnostic value of bronchial wash and sputum has been debated extensively over the years. In this study, we aim to compare the diagnostic value in several pathogens of bronchoalveolar lavage and bronchial wash, and secondarily bronchoalveolar lavage and sputum. Methods We retrospectively included all adult patients in our hospital who underwent bronchoalveolar lavage, bronchial wash, and where sputum sampling was done between January 1st of 2018 and December 31st of 2021. The intraclass correlation coefficient was computed for the three tests. Results In total, 308 patients were included. We found a level of correlation of 0.819 and 0.865, respectively, between bronchoalveolar lavage and bronchial wash for two pathogens: Staphylococcus aureus and Pseudomonas aeruginosa. For Stenotrophomonas maltophilia and Aspergillus fumigatus, we found an intraclass correlation coefficient of 0.568 and 0.624, respectively. Between bronchoalveolar lavage and sputum, we found varying levels of agreement. Conclusion Our study shows reasonably well agreement levels between bronchoalveolar lavage and bronchial wash, suggesting that bronchial wash could potentially be an alternative to bronchoalveolar lavage.
Læs mere Tjek på PubMedInfection, 10.04.2024
Tilføjet 10.04.2024
Abstract Purpose The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. The aim of the study was to verify the functionality and correlates of a recently developed PCS score. Methods The PCS score was applied to the prospective, multi-center cross-sectoral cohort (in- and outpatients with SARS-CoV-2 infection) of the "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment and patient-reported outcome measure questionnaires were analyzed at 3 and 12 months (3/12MFU) after diagnosis. Scores indicative of PCS severity were compared and correlated to demographic and clinical characteristics as well as quality of life (QoL, EQ-5D-5L). Results Six hundred three patients (mean 54.0 years, 60.6% male, 82.0% hospitalized) were included. Among those, 35.7% (215) had no and 64.3% (388) had mild, moderate, or severe PCS. PCS severity groups differed considering sex and pre-existing respiratory diseases. 3MFU PCS worsened with clinical severity of acute infection (p = .011), and number of comorbidities (p = .004). PCS severity was associated with poor QoL at the 3MFU and 12MFU (p
Læs mere Tjek på PubMedInfection, 10.04.2024
Tilføjet 10.04.2024
Infection, 10.04.2024
Tilføjet 10.04.2024
Infection, 10.04.2024
Tilføjet 10.04.2024
Abstract Purpose Rare yeasts species are increasingly reported as causative agents of invasive human infection. Proper identification and antifungal therapy are essential to manage these infections. Candida blankii is one of these emerging pathogens and is known for its reduced susceptibility to multiple antifungals. Methods To obtain more insight into the characteristics of this species, 26 isolates reported as C. blankii were investigated using genetic and phenotypical approaches. Results Among the 26 isolates, seven recovered either from blood, sputum, urine, or the oral cavity, displayed substantial genetic and some phenotypical differences compared to the other isolates, which were confirmed as C. blankii. We consider these seven strains to represent a novel species, Tardiomyces depauwii. Phylogenomics assigned C. blankii, C. digboiensis, and the novel species in a distinct branch within the order Dipodascales, for which the novel genus Tardiomyces is erected. The new combinations Tardiomyces blankii and Tardiomyces digboiensis are introduced. Differences with related, strictly environmental genera Sugiyamaella, Crinitomyces, and Diddensiella are enumerated. All three Tardiomyces species share the rare ability to grow up to 42 °C, display slower growth in nutrient-poor media, and show a reduced susceptibility to azoles and echinocandins. Characteristics of T. depauwii include high MIC values with voriconazole and a unique protein pattern. Conclusion We propose the novel yeast species Tardiomyces depauwii and the transfer of C. blankii and C. digboiensis to the novel Tardiomyces genus.
Læs mere Tjek på PubMedJournal of Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
To the editor—We would like to thank our colleagues Mattiuzzi and Lippi for confirming our conclusion [1] on Spanish flu being deadlier than coronavirus disease 2019 (COVID-19) by Italian figures [2]. Italy was the first European country hit by the COVID-19 pandemic and it was hit very hard. A reflection on death toll puts the events in a historical perspective. The conclusion of our Italian colleagues is based on a comparison of crude death rates. However, when comparing both pandemics, the difference of population structure should be taken into account. Therefore, we compared not only crude death rates, but also age-standardized death rates. As there is no gold standard in this case, we projected both the age-specific Spanish flu figures of 1918–1920 on the (average) 2020–2022 population, and conversely, we projected the age-specific COVID-19 figures of 2020–2022 on the (average) 1918–1920 population. The first projection resulted in a Spanish flu:COVID-19 ratio of 2.2, the second in a Spanish flu:COVID-19 ratio of 6.9. The outcome of the second projection is close to the estimate of our Italian colleagues.
Læs mere Tjek på PubMedJournal of Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
To the Editor—We read with great interest the results of the analysis by Harteloh et al [1], who concluded that the death rate in The Netherlands from the 1918–1920 Spanish flu was more than twice as high as the death rate for coronavirus disease 2019 (COVID-19) in 2020–2022 (ie, 214 vs 98 per 100 000 per year exposure). This is not surprising as the pathogen responsible for the Spanish flu pandemic (ie, influenza virus A/H1N1) was very aggressive, hit a nearly naive population with no prior immunity, and evolved at a time when healthcare and economic resources were extremely limited compared to recent times. To determine whether similar evidence could be replicated in other countries, we used statistics on the total resident population and the number of deaths from the Spanish flu in 1918–1920 [2] and from COVID-19 in 2020 [3] (ie, before the introduction of COVID-19 vaccination at the end of December 2020) in Italy.
Læs mere Tjek på PubMedJournal of Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
Abstract Background Warfare has long impeded vaccination programs in polio-endemic Afghanistan. We aimed to describe progress in access to children under 5, oral polio vaccine (OPV) coverage among children under 5 in nationwide polio campaigns, and polio surveillance performance indicators after the Islamic Republic of Afghanistan collapsed to Taliban forces in August 2021.Methods Trends in the number of wild poliovirus type 1 (WPV1) and circulating vaccine-derived poliovirus type 2 (cVDPV2) cases and surveillance indicators from 2015 to 2023, and trends in the OPV coverage in the November 2020–June 2022 polio campaigns, were described.Results From 2015 to mid-July 2020, 74 of 126 (58.7%) WPV1 cases were reported from inaccessible areas. In November 2020, 34.1% of target children under 5 were inaccessible; in November 2021 (the first postchange polio campaign), all were accessible. From November 2020, under-5 OPV coverage of 69.9% rose steadily to 99.9% in the May 2022 campaign. The number of cVDPV cases fell from 308 (2020) to zero (2022). June 2022\'s house-to-house OPV coverage was 34.2% higher than non–house-to-house modalities. Nonpolio acute flaccid paralysis and stool adequacy rates rose from 18.5/100 000 and 92.6% in 2020 to 24.3/100 000 and 94.4% in 2022, respectively.Conclusions Children\'s inaccessibility no longer vitiates polio eradication; polio surveillance systems are less likely to miss any poliovirus circulation.
Læs mere Tjek på PubMedJournal of Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
Abstract The association between granulomas and vaccine-derived rubella virus (VDRV) in people with primary immune deficiencies (PID) has raised concerns about the ability of immunoglobulin (IG) preparations to neutralize VDRVs. We investigated the capacity of IG to neutralize rubella vaccine virus and four VDRV strains. As expected, the rubella vaccine virus itself was potently neutralized by IG preparations; however, the VDRV isolates from patients after intra-host evolution, 2-6 times less so. Diagnosis of immune deficiencies before possible live-virus vaccination is thus of critical importance, while IG replacement therapy can be expected to provide protection from rubella virus infection.
Læs mere Tjek på PubMedAndrew S. HaynesZixuan WeiPeter AndersonMarc H. ScheetzSarah K. ParkerDouglas N. Fish1Children’s Hospital Colorado, Department of Pediatrics, Section of Pediatric Infectious Diseases, Aurora, Colorado, USA2University of Colorado Anschutz Medical Campus, School of Medicine, Aurora, Colorado, USA3University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA4Midwestern University, Pharmacometrics Center of Excellence, Colleges of Pharmacy and Pharmacology, Downers Grove, Illinois, USA, Andreas H. Groll
Antimicrobial Agents And Chemotherapy, 10.04.2024
Tilføjet 10.04.2024
Allan KengoFirdaus NabeemeeahPaolo DentiRyan SabetGifty Okyere-ManuPattamukkil AbrahamLubbe WeisnerModiehi Helen MosalaSibongile TshabalalaJanine ScholefieldJuan Eduardo Resendiz-GalvanNeil A. MartinsonEbrahim Variava1Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa2Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa3Bioengineering and Integrated Genomics Group, Council for Scientific and Industrial Research, Pretoria, South Africa4Johns Hopkins University Center for Tuberculosis Research, Division of Infectious Diseases, School of Medicine, Baltimore, Maryland, USA5Department of Internal Medicine, University of the Witwatersrand, Klerksdorp/Tshepong Hospital Complex North-West Province, Klerksdorp-Tshepong, South Africa, James E. Leggett
Antimicrobial Agents And Chemotherapy, 10.04.2024
Tilføjet 10.04.2024
Makoto SaitoPornpimon WilaisrisakMupawjay PimanpanarakJacher Viladpai-NguenMoo Kho PawUrairat KoesukwiwatJoel TarningNicholas J. WhiteFrancois NostenRose McGready1Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand2Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom3Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan4Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Audrey Odom John
Antimicrobial Agents And Chemotherapy, 10.04.2024
Tilføjet 10.04.2024
Isabel A.L. Slurink, Sophie C.M. van den Houdt, Gaëtan Mertens
International Journal of Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
Even though most people infected with severe acute respiratory syndrome coronavirus 2 (i.e., SARS-CoV-2), resulting in Coronavirus disease 2019 (COVID-19) fully recover [1,2], a considerable number of patients continues to experience prolonged symptoms, such as fatigue, neurocognitive problems, and smell and taste impairment [2]. This syndrome of lingering symptoms following COVID-19 is referred to as long COVID or post-COVID syndrome.
Læs mere Tjek på PubMedSurasith Chaithonwongwatthana, Wassana Wijagkanalan, Nasamon Wanlapakorn, Librada Fortuna, Vilasinee Yuwaree, Chawanee Kerdsomboon, Indrajeet Kumar Poredi, Souad Mansouri, Pham Hong Thai, Yong Poovorawan
International Journal of Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
Pertussis, caused by Bordetella pertussis, is a highly contagious respiratory disease that poses a significant risk to young infants, resulting in both severe morbidity and mortality [1]. Among infants with pertussis, approximately 4% of cases are fatal. Dramatic decreases in pediatric pertussis cases and deaths have resulted from infant vaccination programs, which include whole-cell vaccines based on killed B. pertussis and acellular pertussis (aP) vaccines using highly purified B. pertussis antigens [1].
Læs mere Tjek på PubMedJournal of the American Medical Association, 10.04.2024
Tilføjet 10.04.2024
Humans are aerobic animals; we need oxygen to support metabolism and generate energy. Simply put, breathing oxygen is necessary for life. Consequently, it would make sense that diseases that inhibit the transfer of oxygen from the lung to the blood should be treated with supplementary oxygen to overcome problems associated with hypoxemia, and one should strive to achieve “normal” levels of arterial oxygen (Pao2). But is that reasoning supported by the understanding of physiology and the weight of clinical evidence?
Læs mere Tjek på PubMedJournal of the American Medical Association, 10.04.2024
Tilføjet 10.04.2024
This randomized clinical trial assesses the effect of targeting a lower vs higher oxygenation level on 90-day survival without need for life support among intensive care unit patients with COVID-19 and severe hypoxemia.
Læs mere Tjek på PubMedJournal of the American Medical Association, 10.04.2024
Tilføjet 10.04.2024
A new study published in JAMA Network Open suggests that female sex may be related to an increased likelihood of death from Staphylococcus aureus bacteremia (SAB), which is the leading cause of death from bacterial bloodstream infection. Compared with male patients, female patients in the study had 18% increased odds of mortality from the infection. To calculate this risk, researchers performed a systematic review and meta-analysis of 89 observational studies including more than 130 000 patients.
Læs mere Tjek på PubMedMark P. NelderRachel SchatsHendrik N. PoinarAmanda CookeMegan B. BrickleyaEnteric, Zoonotic and Vector-Borne Diseases, Health Protection, Public Health Ontario, Toronto, ON M5G 1M1, CanadabLaboratory for Human Osteoarchaeology, Faculty of Archaeology, Leiden University, 2333 CC Leiden, The NetherlandscDepartment of Anthropology, McMaster University, Hamilton, ON L8S 4L9, CanadadDepartment of Biochemistry, McMaster University, Hamilton, ON L8S 4L9, CanadaeMcMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, ON L8S 4L9, Canada
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedTimothy J. C. TanAbhishek K. VermaAbby OdleRuipeng LeiDavid K. MeyerholzKenneth A. MatreyekStanley PerlmanLok-Yin Roy WongNicholas C. WuaCenter for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801bDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242cDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801dDepartment of Pathology, University of Iowa, Iowa City, IA 52242eDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106fDepartment of Pediatrics, University of Iowa, Iowa City, IA 52242gCenter for Virus-Host-Innate Immunity, Rutgers New Jersey Medical School, Newark, NJ 07103hDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103iCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801jCarle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedQiwei YuYing QuLiqiang ZhangXin YaoJing YangSiyuan ChenHui LiuQihao WangMengfan WuJunpei TaoChenghu ZhouIsiaka Lukman AlageSuhong LiuaDepartment of Geography, State Key Laboratory of Remote Sensing Science, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, ChinabState Key Laboratory of Resources and Environmental Information System, Institute of Geographical Science and Natural Resources, Chinese Academy of Sciences, Beijing 100101, ChinacSpace Research and Development Division, African Regional Centre for Space Science and Technology Education in English Ile ife, Ile ife, Osun 220282, Nigeria
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedMahdi NasiriEdwin LoranBenno LiebchenaInstitute of Condensed Matter Physics, Department of Physics, Technische Universität Darmstadt, Darmstadt D-64289, Germany
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedAvik BiswasIndrani ChoudhuriEddy ArnoldDmitry LyumkisAllan HaldaneRonald M. LevyaCenter for Biophysics and Computational Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122bLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037cDepartment of Physics, University of California San Diego, La Jolla, CA 92093dDepartment of Chemistry, Temple University, Philadelphia, PA 19122eDepartment of Chemistry and Chemical Biology, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854fGraduate School of Biological Sciences, Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093gDepartment of Physics, Temple University, Philadelphia, PA 19122
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedDavid Carrasco FloresVivien HotterTrang VuongYu HouYuko BandoKirstin ScherlachBertille Burgunter-DelamareRon HermenauAnna J. KomorPrasad AiyarMagdalena RoseSeverin SassoHans-Dieter ArndtChristian HertweckMaria MittagaMatthias Schleiden Institute of Genetics, Bioinformatics and Molecular Botany, General Botany, Friedrich Schiller University Jena, Jena 07743, GermanybInstitute for Organic Chemistry and Macromolecular Chemistry, Organic Chemistry, Friedrich Schiller University Jena, Jena 07743, GermanycDepartment of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute), Jena 07745, GermanydInstitute of Biology, Plant Physiology, Leipzig University, Leipzig 04103, GermanyeCluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena 07743, GermanyfFaculty of Biological Sciences, Friedrich Schiller University Jena, Jena 07743, Germany
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedClayton J. OtterNicole BracciNicholas A. ParentiChengjin YeAbhishek AsthanaEbba K. BlomqvistLi Hui TanJessica J. PfannenstielNathaniel JacksonAnthony R. FehrRobert H. SilvermanJames M. BurkeNoam A. CohenLuis Martinez-SobridoSusan R. WeissaDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104bPenn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104cDisease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, TX 78227dDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195eDepartment of Molecular Medicine, The Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458fDepartment of Immunology and Microbiology, The Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458gDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104hDepartment of Surgery, Corporal Michael J. Crescenz Veterans Administration Medical Center, Philadelphia, PA 19104iDepartment of Molecular Biosciences, University of Kansas, Lawrence, KS 66045
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedDouglas L. HusebySha CaoEdouard ZamaratskiSanjeewani SooriyaarachchiShabbir AhmadTerese BergforsLaura KrasnovaJuris PelssMartins IkaunieksEinars LozaMartins KatkevicsOlga BobilevaHelena CiruleBaiba GukalovaSolveiga GrinbergaMaria BacklundIvailo SimoffAnna T. LeberTalía Berruga-FernándezDmitry AntonovVivekananda R. KondaStefan LindströmGustav OlandersPeter BrandtPawel BaranczewskiCarina Vingsbo LundbergEdgars LiepinshEdgars SunaT. Alwyn JonesSherry L. MowbrayDiarmaid HughesAnders KarlénaDepartment of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala SE-75123, SwedenbDepartment of Medicinal Chemistry, BMC, Uppsala University, Uppsala SE-75123, SwedencDepartment of Cell and Molecular Biology, BMC, Uppsala University, Uppsala SE-75123, SwedendLatvian Institute of Organic Synthesis, Riga LV-1006, LatviaeDepartment of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling, Uppsala University, Uppsala SE-75123, SwedenfDepartment of Pharmacy, SciLifeLab Drug Discovery and Development Platform, Uppsala University, Uppsala SE-75123, SwedengBacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen 2300, Denmark
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedYannick CyrFazli K. BozalJosé Gabriel Barcia DuránAlexandra A. C. NewmanLetizia AmadoriPanagiotis SmyrnisMorgane GourvestDayasagar DasMichael GildeaRavneet KaurTracy ZhangKristin M. WangRichard Von ItterP. Martin SchlegelSamantha D. DupuisBernard F. SanchezAnn Marie SchmidtEdward A. FisherCoen van SolingenChiara GiannarelliKathryn J. MooreaCardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016bDepartment of Anesthesiology and Intensive Care, School of Medicine and Health, Technical University of Munich, Munich 81675, GermanycDivision of Endocrinology, Diabetes and Metabolism, New York University Langone Health, New York, NY 10016dDepartment of Cell Biology, New York University Grossman School of Medicine, New York, NY 10016eDepartment of Pathology, New York University Grossman School of Medicine, New York, NY 10016
Proceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedProceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMedProceedings of the National Academy of Sciences, 10.04.2024
Tilføjet 10.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 15, April 2024.
Læs mere Tjek på PubMed