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Søgeord (listeria) valgt.
11 emner vises.
Victoria ChevéeKarthik HullahalliKatherine G. DaileyLeslie GüerecaChenyu ZhangMatthew K. WaldorDaniel A. PortnoyaDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720bDivision of Infectious Diseases, Brigham and Women’s Hospital, Boston, MA 02115cDepartment of Microbiology, Harvard Medical School, Boston, MA 02115dHHMI, Bethesda, MD 20815eDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720
Proceedings of the National Academy of Sciences, 24.04.2024
Tilføjet 24.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 17, April 2024.
Læs mere Tjek på PubMedFlorian Blanchard, Benoît Henry, Sofieya Vijayaratnam, Etienne Canouï, Alexandra Moura, Pierre Thouvenot, Hélène Bracq-Dieye, Nathalie Tessaud-Rita, Guillaume Valès, Andrée Diakité, Alexandre Leclercq, Marc Lecuit, Caroline Charlier, Listeria monocytogenes-associated Spontaneous Peritonitis Study Group
Lancet Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
Despite the non-specific and mild presentation of L monocytogenes-associated spontaneous bacterial peritonitis, the outcome is poor and similar to that of neurolisteriosis, and so identification of L monocytogenes in ascitic fluid samples requires urgent parenteral amoxicillin-based treatment to avoid a fatal outcome.
Læs mere Tjek på PubMedInfection, 8.03.2024
Tilføjet 8.03.2024
Abstract Background Listeria monocytogenes is a bacterial pathogen known for causing listeriosis, a foodborne illness with a wide spectrum of clinical presentations ranging from mild gastroenteritis to severe invasive disease, particularly affecting immunocompromised individuals, pregnant women, newborns, and the elderly. Successful treatment of patients with recurring listeria episodes due to colonised foreign material is often challenging, typically requiring a combination of antimicrobial treatment and surgical removal. Case presentation Here, we present a particularly complex case of chronic invasive listeriosis with a total of six relapses. After extensive investigations, the patient\'s ICD device was identified as the focus of infection. Conclusion The confirmation of relapses through cgMLST analysis highlights the persistence of Listeria monocytogenes and the potential for recurrence even after apparent resolution of symptoms in patients with foreign material. It emphasises the necessity for a comprehensive assessment to identify and mitigate the risk of relapses, thereby ensuring optimal management and outcomes.
Læs mere Tjek på PubMedInfection, 7.03.2024
Tilføjet 7.03.2024
Abstract Background Listeria monocytogenes is a bacterial pathogen known for causing listeriosis, a foodborne illness with a wide spectrum of clinical presentations ranging from mild gastroenteritis to severe invasive disease, particularly affecting immunocompromised individuals, pregnant women, newborns, and the elderly. Successful treatment of patients with recurring listeria episodes due to colonised foreign material is often challenging, typically requiring a combination of antimicrobial treatment and surgical removal. Case presentation Here, we present a particularly complex case of chronic invasive listeriosis with a total of six relapses. After extensive investigations, the patient\'s ICD device was identified as the focus of infection. Conclusion The confirmation of relapses through cgMLST analysis highlights the persistence of Listeria monocytogenes and the potential for recurrence even after apparent resolution of symptoms in patients with foreign material. It emphasises the necessity for a comprehensive assessment to identify and mitigate the risk of relapses, thereby ensuring optimal management and outcomes.
Læs mere Tjek på PubMedXiomarie Alejandro-NavarretoNancy E. Freitag1Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, USA2Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA, Karen M. Ottemann
Infection and Immunity, 5.03.2024
Tilføjet 5.03.2024
John C. BerudePaul KennoucheMichelle L. ReniereDaniel A. Portnoy1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA2Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA, Andreas J. Bäumler
Infection and Immunity, 30.01.2024
Tilføjet 30.01.2024
Farhana Boby, Md. Nurul Huda Bhuiyan, Barun Kanti Saha, Subarna Sandhani Dey, Anik Kumar Saha, Md Jahidul Islam, Mahci Al Bashera, Shyama Prosad Moulick, Farhana Jahan, Md. Asad Uz Zaman, Sanjana Fatema Chowdhury, Showti Raheel Naser, Md. Salim Khan, Md. Murshed Hasan Sarkar
PLoS One Infectious Diseases, 16.11.2023
Tilføjet 16.11.2023
by Farhana Boby, Md. Nurul Huda Bhuiyan, Barun Kanti Saha, Subarna Sandhani Dey, Anik Kumar Saha, Md Jahidul Islam, Mahci Al Bashera, Shyama Prosad Moulick, Farhana Jahan, Md. Asad Uz Zaman, Sanjana Fatema Chowdhury, Showti Raheel Naser, Md. Salim Khan, Md. Murshed Hasan Sarkar The raising concern of drug resistance, having substantial impacts on public health, has instigated the search of new natural compounds with substantial medicinal activity. In order to find out a natural solution, the current study has utilized prodigiosin, a linear tripyrrole red pigment, as an active ingredient to control bacterial proliferation and prevent cellular oxidation caused by ROS (Reactive Oxygen Species). A prodigiosin-producing bacterium BRL41 was isolated from the ancient Barhind soil of BCSIR Rajshahi Laboratories, Bangladesh, and its morphological and biochemical characteristics were investigated. Whole genome sequencing data of the isolate revealed its identity as Serratia sp. and conferred the presence of prodigiosin gene cluster in the bacterial genome. “Prodigiosin NRPS”, among the 10 analyzed gene clusters, showed 100% similarity with query sequences where pigC, pigH, pigI, and pigJ were identified as fundamental genes for prodigiosin biosynthesis. Some other prominent clusters for synthesis of ririwpeptides, yersinopine, trichrysobactin were also found in the chromosome of BRL41, whilst the rest displayed less similarity with query sequences. Except some first-generation beta-lactam resistance genes, no virulence and resistance genes were found in the genome of BRL41. Structural illumination of the extracted red pigment by spectrophotometric scanning, Thin-Layer Chromatography (TLC), Fourier Transform Infrared Spectroscopy (FTIR), and change of color at different pH solutions verified the identity of the isolated compound as prodigiosin. Serratia sp. BRL41 attained its maximum productivity 564.74 units/cell at temperature 30˚C and pH 7.5 in two-fold diluted nutrient broth medium. The compound exhibited promising antibacterial activity against Gram-positive and Gram-negative bacteria with MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) values ranged from 3.9 to15.62 μg/mL and 7.81 to 31.25 μg/mL respectively. At concentration 500 μg/mL, except in Salmonella enterica ATCC-10708, prodigiosin significantly diminished biofilm formed by Listeria monocytogens ATCC-3193, Pseudomonas aeruginosa ATCC-9027, Escherichia coli (environmental isolate), Staphylococcus aureus (environmental isolate). Cellular glutathione level (GSH) was elevated upon application of 250 and 500 μg/mL pigment where 125 μg/mL failed to show any free radical scavenging activity. Additionally, release of cellular components in growth media of both Gram-positive and Gram-negative bacteria were facilitated by the extract that might be associated with cell membrane destabilization. Therefore, the overall findings of antimicrobial, antibiofilm and antioxidant activities suggest that in time to come prodigiosin might be a potential natural source to treat various diseases and infections.
Læs mere Tjek på PubMedListeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence
Hans B. SmithKijeong LeeMatthew J. FreemanDavid M. StevensonDaniel Amador-NoguezJohn-Demian Sauer 1 Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA 2 Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA , Nancy E. Freitag
Infection and Immunity, 27.09.2023
Tilføjet 27.09.2023
Mariam M. Abdulkadieva, Elena V. Sysolyatina, Elena V. Vasilieva, Veronika V. Litvinenko, Egor V. Kalinin, Vladimir G. Zhukhovitsky, Natalia V. Shevlyagina, Svetlana G. Andreevskaya, Yaroslav M. Stanishevskyi, Mikhail M. Vasiliev, Oleg F. Petrov, Svetlana A. Ermolaeva
PLoS One Infectious Diseases, 1.09.2023
Tilføjet 1.09.2023
by Mariam M. Abdulkadieva, Elena V. Sysolyatina, Elena V. Vasilieva, Veronika V. Litvinenko, Egor V. Kalinin, Vladimir G. Zhukhovitsky, Natalia V. Shevlyagina, Svetlana G. Andreevskaya, Yaroslav M. Stanishevskyi, Mikhail M. Vasiliev, Oleg F. Petrov, Svetlana A. Ermolaeva Listeria monocytogenes is motile at 22°C and non-motile at 37°C. In contrast, expression of L. monocytogenes virulence factors is low at 22°C and up-regulated at 37°C. Here, we studied a character of L. monocytogenes near surface swimming (NSS) motility and its effects on adhesion patterns and invasion into epithelial cells. L. monocytogenes and its saprophytic counterpart L. innocua both grown at 22°C showed similar NSS characteristics including individual velocities, trajectory lengths, residence times, and an asymmetric distribution of velocity directions. Similar NSS patterns correlated with similar adhesion patterns. Motile bacteria, including both pathogenic and saprophytic species, showed a preference for adhering to the periphery of epithelial HEp-2 cells. In contrast, non-motile bacteria were evenly distributed across the cell surface, including areas over the nucleus. However, the uneven distribution of motile bacteria did not enhance the invasion into HEp-2 cells unless virulence factor production was up-regulated by the transient shift of the culture to 37°C. Motile L. monocytogenes grown overnight at 22°C and then shifted to 37°C for 2 h expressed invasion factors at the same level and invaded human cells up to five times more efficiently comparatively with non-motile bacteria grown overnight at 37°C. Taken together, obtained results demonstrated that (i) NSS motility and correspondent peripheral location over the cell surface did not depend on L. monocytogenes virulence traits; (ii) motility improved L. monocytogenes invasion into human HEp-2 cells within a few hours after the transition from the ambient temperature to the human body temperature.
Læs mere Tjek på PubMedStephanie B. Orchanian, Melissa B. Lodoen
Trends in Parasitology, 25.08.2023
Tilføjet 25.08.2023
Monocytes are recruited from the bone marrow to sites of infection where they release cytokines and chemokines, function in antimicrobial immunity, and differentiate into macrophages and dendritic cells to control infection. Although many studies have focused on monocyte-derived macrophages and dendritic cells, recent work has examined the unique roles of monocytes during infection to promote immune defense. We focus on the effector functions of monocytes during infection with the parasite Toxoplasma gondii, and discuss the signals that mobilize monocytes to sites of infection, their production of inflammatory cytokines and antimicrobial mediators, their ability to shape the adaptive immune response, and their immunoregulatory functions. Insights from other infections, including Plasmodium and Listeria are also included for comparison and context.
Læs mere Tjek på PubMedJooyoung ChoKatie L. AlexanderJessica L. FerrellLance A. JohnsonSteven EstusSarah E. F. D’Orazio 1 Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA 2 Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA 3 Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky, USA , Andreas J. Bäumler
Infection and Immunity, 18.08.2023
Tilføjet 18.08.2023