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Prevalence and determinants of malaria infection among pregnant women attending antenatal clinic in Ejisu government hospital in Ghana: A cross-sectional study
Catherine Kroamah Dwumfour, Victoria Bubunyo Bam, Lydia Boampong Owusu, Collins Atta Poku, Rhoda Dewe Kpabitey, Priscilla Aboagye, Amshariatu Suntaa Ibrahim
PLoS One Infectious Diseases, 30.10.2023
Tilføjet 30.10.2023
by Catherine Kroamah Dwumfour, Victoria Bubunyo Bam, Lydia Boampong Owusu, Collins Atta Poku, Rhoda Dewe Kpabitey, Priscilla Aboagye, Amshariatu Suntaa Ibrahim Introduction Malaria in pregnancy is a global public health problem with the majority of its impact seen in sub-Saharan Africa. Pregnant women with malaria infection are at risk of adverse maternal outcomes. In Ghana, malaria in pregnancy accounts for about 17.6% of outpatient department attendance. Ashanti region is among the three regions with the highest malaria prevalence in pregnancy, particularly in the Ejisu Municipality. The study, therefore, assessed the prevalence and determinants of malaria infection among pregnant women seeking antenatal care at the Ejisu Government Hospital in Ghana. Methods A cross-sectional study design with a convenience sampling technique was used to select 140 respondents for the study. Primary data such as age and residence of respondents were collected using a questionnaire and secondary data such as gestational age and Sulphadoxine Pyrimethamine (SP) administration were collected from clients’ maternal health record booklet. Bivariate and multivariate logistic regression analysis were used to assess the association between the malaria infection and the independent variables, and a p-value of < 0.05 was considered statistically significant. Results The overall prevalence of malaria in pregnancy was 24 (17.1%). Most of the respondents had received counselling and health education 126 (90%), two or more doses of SP 95 (87.2%), Insecticide Treated Net (ITN) 99 (70.7%) and were sleeping under ITN 104 (74.3%). Multivariate logistic regression analysis showed a statistically significant association between malaria infection and sleeping under ITN (AOR = 0.05; 95% CI = 0.01–0.28, p< .001), the use of insecticide mosquito spray (AOR = 0.27; 95% CI = 0.09–0.84, p = .045) and reason for not using ITN due to the use of other preventive measures (AOR = 0.06; 95% CI = 0.01–0.61, p = .017). Conclusion There was a high prevalence of malaria infection among study respondents despite the high usage of preventive measures for malaria in this study. It is therefore crucial that stakeholders in malaria control identify effective strategies to curb malaria transmission globally.
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352
Mathematical modeling of malaria transmission dynamics in humans with mobility and control states
Infectious Disease Modelling, 22.08.2023
Tilføjet 22.08.2023
Publication date: Available online 21 August 2023 Source: Infectious Disease Modelling Author(s): Gbenga Adegbite, Sunday Edeki, Itunuoluwa Isewon, Jerry Emmanuel, Titilope Dokunmu, Solomon Rotimi, Jelili Oyelade, Ezekiel Adebiyi
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353
Viral modulation of lipid rafts and their potential as putative antiviral targets
Yee Jing Gee; Yi Lin Sea; Sunil Kumar Lal;
Reviews in Medical Virology, 24.04.2023
Tilføjet 24.04.2023
Lipid rafts are ubiquitous in cells. They are identified as cholesterol and glycosphingolipid enriched microdomains on cellular membranes. They serve as platforms for cellular communications by functioning in signal transduction and membrane trafficking. Such structural organisation fulfils cellular needs for normal function, but at the same time increases vulnerability of cells to pathogen invasion. Viruses rely heavily on lipid rafts in basically every stage of the viral life cycle for successful infection. Various mechanisms of lipid rafts modification exploited by diverse viruses for attachment, internalisation, membrane fusion, genome replication, assembly and release have been brought to light. This review focuses on virus‐raft interactions and how a wide range of viruses manipulate lipid rafts at distinct stages of infection. The importance of virus‐raft interactions in viral infections has inspired researchers to discover and develop antivirals that target this interaction, such as statins, methyl‐β‐cyclodextrin, viperin, 25‐hydroxycholesterol and even anti‐malarial drugs. The therapeutic modulations of lipid rafts as potential antiviral intervention from in vitro and in vivo evidence are discussed herein.
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