47 ud af 47 tidsskrifter valgt, søgeord (influenza) valgt, emner højest 180 dage gamle, sorteret efter nyeste først.
209 emner vises.
101
Comparison of geological clusters between influenza and COVID-19 in Thailand with unsupervised clustering analysis
Thanin Methiyothin, Insung Ahn
PLoS One Infectious Diseases, 23.01.2024
Tilføjet 23.01.2024
by Thanin Methiyothin, Insung Ahn The coronavirus disease (COVID-19) pandemic has considerably impacted public health, including the transmission patterns of other respiratory pathogens, such as the 2009 pandemic influenza (H1N1). COVID-19 and influenza are both respiratory infections that started with a lack of vaccination-based immunity in the population. However, vaccinations have been administered over time, resulting in a transition of the status of both diseases from a pandemic to an endemic. In this study, unsupervised clustering techniques were used to identify clusters of disease trends in Thailand. The analysis incorporated three distinct surveillance datasets: the pandemic influenza outbreak, influenza in the endemic stage, and the early stages of COVID-19. The analysis demonstrated a significant difference in the distribution of provinces between Cluster -1, representing those with unique transmission patterns, and the other clusters, indicating provinces with similar transmission patterns among their members. Specifically, for Pandemic Influenza, the ratio was 61:16, while for Pandemic COVID-19, it was 65:12. In contrast, Endemic Influenza exhibited a ratio of 46:31, with a notable emergence of more clustered provinces in the southern, western, and central regions. Furthermore, a pair of provinces with highly similar spreading patterns were identified during the pandemic stages of both influenza and COVID-19. Although the similarity decreased slightly for endemic influenza, they still belonged to the same cluster. Our objective was to identify the transmission patterns of influenza and COVID-19, with the aim of providing quantitative and spatial information to aid public health management in preparing for future pandemics or transitioning into an endemic phase.
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102
Immunogenicity and safety of concomitant bivalent COVID-19 and quadrivalent influenza vaccination: Implications of immune imprinting and interference
Min Joo Choi, Young Jun Yu, Jae Won Kim, Hea Jeon Ju, So Youn Shin, Yun-Jung Yang, Hee Jin Cheong, Woo Joo Kim, Chulwoo Kim, Hwa Jung Kim, Sun Kyung Yoon, Se-Jin Park, WonSeok Gwak, June-Woo Lee, Byoungguk Kim, Joon Young Song
Clinical Microbiology and Infection, 21.01.2024
Tilføjet 21.01.2024
Concomitant COVID-19 and influenza vaccination would be an efficient strategy. While the co-administration of monovalent COVID-19 and influenza vaccinations showed acceptable immunogenicity, it remains unknown whether the bivalent COVID-19 vaccine could intensify immune interference. We aimed to evaluate the immunogenicity and safety of concomitant BA.5-based bivalent COVID-19 and influenza vaccination.
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103
Concomitant administration of seasonal influenza and COVID-19 mRNA vaccines
Teresa AydilloMaria Balsera-ManzaneroAmaya Rojo-FernandezAlba EscaleraCelia Salamanca-RiveraJerónimo PachónMaría Del Mar Muñoz-GarcíaMaría José Sánchez-CorderoJavier Sánchez-CéspedesAdolfo García-SastreElisa Corderoa Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, USAb Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, USAc Viral Diseases and Infections in Immunodeficiencies Research Group, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spaind Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USAe Unit of Infectious Diseases, Microbiology and Parasitology, Virgen del Rocío University Hospital, Sevilla, Spainf Department of Preventive Medicine, University of Seville, Spaing CIBERINFEC, CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spainh Department of Medicine, School of Medicine, University of Sevilla, Sevilla, Spaini Health Care Center Los Bermejales, Primary Care District, Andalusian Health Service, Sevillej Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, USAk Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, USAl Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, USA
Emerg Microbes Infect, 19.01.2024
Tilføjet 19.01.2024
104
Identification of dihydroorotate dehydrogenase inhibitor, vidofludimus, as a potent and novel inhibitor for influenza virus
Jiazhou Li, Midori Takeda, Mikiko Imahatakenaka, Masanori Ikeda
Journal of Medical Virology, 19.01.2024
Tilføjet 19.01.2024
105
Uncovering the burden of Influenza in children in Portugal, 2008–2018
BMC Infectious Diseases, 19.01.2024
Tilføjet 19.01.2024
Abstract Background Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged
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106
Emergence of novel reassortant H3N3 avian influenza viruses with increased pathogenicity in chickens in 2023
Qiuyan MaoShuning ZhouShuo LiuCheng PengXin YinJinping LiYaxin ZhangWanting ZhouGuangyu HouWenming JiangHualei Liua China Animal Health and Epidemiology Center, Qingdao, People’s Republic of Chinab College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang Agriculture and Forestry University, Hangzhou, People’s Republic of Chinac College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, People’s Republic of Chinad College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, People’s Republic of China
Emerg Microbes Infect, 17.01.2024
Tilføjet 17.01.2024
107
Socioeconomic impacts of airborne and droplet-borne infectious diseases on industries: a systematic review
BMC Infectious Diseases, 16.01.2024
Tilføjet 16.01.2024
Abstract Background Recent pandemics have had far-reaching effects on the world’s largest economies and amplified the need to estimate the full extent and range of socioeconomic impacts of infectious diseases outbreaks on multi-sectoral industries. This systematic review aims to evaluate the socioeconomic impacts of airborne and droplet-borne infectious diseases outbreaks on industries. Methods A structured, systematic review was performed according to the PRISMA guidelines. Databases of PubMed, Scopus, Web of Science, IDEAS/REPEC, OSHLINE, HSELINE, and NIOSHTIC-2 were reviewed. Study quality appraisal was performed using the Table of Evidence Levels from Cincinnati Children’s Hospital Medical Center, Joanna Briggs Institute tools, Mixed Methods Appraisal Tool, and Center of Evidence Based Management case study critical appraisal checklist. Quantitative analysis was not attempted due to the heterogeneity of included studies. A qualitative synthesis of primary studies examining socioeconomic impact of airborne and droplet-borne infectious diseases outbreaks in any industry was performed and a framework based on empirical findings was conceptualized. Results A total of 55 studies conducted from 1984 to 2021 were included, reporting on 46,813,038 participants working in multiple industries across the globe. The quality of articles were good. On the whole, direct socioeconomic impacts of Coronavirus Disease 2019, influenza, influenza A (H1N1), Severe Acute Respiratory Syndrome, tuberculosis and norovirus outbreaks include increased morbidity, mortality, and health costs. This had then led to indirect impacts including social impacts such as employment crises and reduced workforce size as well as economic impacts such as demand shock, supply chain disruptions, increased supply and production cost, service and business disruptions, and financial and Gross Domestic Product loss, attributable to productivity losses from illnesses as well as national policy responses to contain the diseases. Conclusions Evidence suggests that airborne and droplet-borne infectious diseases have inflicted severe socioeconomic costs on regional and global industries. Further research is needed to better understand their long-term socioeconomic impacts to support improved industry preparedness and response capacity for outbreaks. Public and private stakeholders at local, national, and international levels must join forces to ensure informed systems and sector-specific cost-sharing strategies for optimal global health and economic security.
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108
Socioeconomic impacts of airborne and droplet-borne infectious diseases on industries: a systematic review
BMC Infectious Diseases, 16.01.2024
Tilføjet 16.01.2024
Abstract Background Recent pandemics have had far-reaching effects on the world’s largest economies and amplified the need to estimate the full extent and range of socioeconomic impacts of infectious diseases outbreaks on multi-sectoral industries. This systematic review aims to evaluate the socioeconomic impacts of airborne and droplet-borne infectious diseases outbreaks on industries. Methods A structured, systematic review was performed according to the PRISMA guidelines. Databases of PubMed, Scopus, Web of Science, IDEAS/REPEC, OSHLINE, HSELINE, and NIOSHTIC-2 were reviewed. Study quality appraisal was performed using the Table of Evidence Levels from Cincinnati Children’s Hospital Medical Center, Joanna Briggs Institute tools, Mixed Methods Appraisal Tool, and Center of Evidence Based Management case study critical appraisal checklist. Quantitative analysis was not attempted due to the heterogeneity of included studies. A qualitative synthesis of primary studies examining socioeconomic impact of airborne and droplet-borne infectious diseases outbreaks in any industry was performed and a framework based on empirical findings was conceptualized. Results A total of 55 studies conducted from 1984 to 2021 were included, reporting on 46,813,038 participants working in multiple industries across the globe. The quality of articles were good. On the whole, direct socioeconomic impacts of Coronavirus Disease 2019, influenza, influenza A (H1N1), Severe Acute Respiratory Syndrome, tuberculosis and norovirus outbreaks include increased morbidity, mortality, and health costs. This had then led to indirect impacts including social impacts such as employment crises and reduced workforce size as well as economic impacts such as demand shock, supply chain disruptions, increased supply and production cost, service and business disruptions, and financial and Gross Domestic Product loss, attributable to productivity losses from illnesses as well as national policy responses to contain the diseases. Conclusions Evidence suggests that airborne and droplet-borne infectious diseases have inflicted severe socioeconomic costs on regional and global industries. Further research is needed to better understand their long-term socioeconomic impacts to support improved industry preparedness and response capacity for outbreaks. Public and private stakeholders at local, national, and international levels must join forces to ensure informed systems and sector-specific cost-sharing strategies for optimal global health and economic security.
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109
[Articles] Bacterial nasopharyngeal colonisation in children in South Africa before and during the COVID-19 pandemic: an observational study
Courtney P Olwagen, Sarah L Downs, Alane Izu, Lebohang Tharasimbi, Lara Van Der Merwe, Marta C Nunes, Shabir A Madhi
The Lancet Microbe, 16.01.2024
Tilføjet 16.01.2024
There were variable effects on the colonisation prevalence and density of bacterial organisms during the COVID-19 compared with the pre-COVID-19 period. The lower prevalence of PCV13 serotype together with other respiratory organisms including non-typeable H influenzae and M catarrhalis could have in part contributed to a decrease in all-cause lower respiratory tract infections observed in South Africa during the initial stage of the COVID-19 pandemic. The pathophysiological mechanism for the increase in A baumannii and S aureus colonisation warrants further investigation, as does the clinical relevance of these findings.
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110
Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial
BMC Infectious Diseases, 15.01.2024
Tilføjet 15.01.2024
Abstract Brief summary In early symptomatic COVID-19 treatment, high dose oral favipiravir did not accelerate viral clearance. Background Favipiravir, an anti-influenza drug, has in vitro antiviral activity against SARS-CoV-2. Clinical trial evidence to date is inconclusive. Favipiravir has been recommended for the treatment of COVID-19 in some countries. Methods In a multicentre open-label, randomised, controlled, adaptive platform trial, low-risk adult patients with early symptomatic COVID-19 were randomised to one of ten treatment arms including high dose oral favipiravir (3.6g on day 0 followed by 1.6g daily to complete 7 days treatment) or no study drug. The primary outcome was the rate of viral clearance (derived under a linear mixed-effects model from the daily log10 viral densities in standardised duplicate oropharyngeal swab eluates taken daily over 8 days [18 swabs per patient]), assessed in a modified intention-to-treat population (mITT). The safety population included all patients who received at least one dose of the allocated intervention. This ongoing adaptive platform trial was registered at ClinicalTrials.gov (NCT05041907) on 13/09/2021. Results In the final analysis, the mITT population contained data from 114 patients randomised to favipiravir and 126 patients randomised concurrently to no study drug. Under the linear mixed-effects model fitted to all oropharyngeal viral density estimates in the first 8 days from randomisation (4,318 swabs), there was no difference in the rate of viral clearance between patients given favipiravir and patients receiving no study drug; a -1% (95% credible interval: -14 to 14%) difference. High dose favipiravir was well-tolerated. Interpretation Favipiravir does not accelerate viral clearance in early symptomatic COVID-19. The viral clearance rate estimated from quantitative measurements of oropharyngeal eluate viral densities assesses the antiviral efficacy of drugs in vivo with comparatively few studied patients.
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111
First global report about the prevalence of multi-drug resistant Haemophilus influenzae: a systematic review and meta-analysis
BMC Infectious Diseases, 15.01.2024
Tilføjet 15.01.2024
Abstract Background In recent decades, the prevalence of antibiotic resistance is increasing in Haemophilus influenzae (Haemophilus influenzae), which poses important challenges to global health. This research offers a comprehensive meta-analysis of the global epidemiology of multi-drug resistant (MDR) H. influenzae. Methods In this study, we conducted a meta-analysis based on PRISMA checklist. Electronic databases including PubMed, ISI Web of Science, Scopus, EMBASE, and Google Scholar were reviewed using keywords related to H. influenzae and antibiotic resistance. Eligible studies were selected based on stringent inclusion and exclusion criteria. Then, data from these studies were analyzed using the Comprehensive Meta-Analysis (CMA) software. Results Of 375 retrieved articles, 16 met the inclusion criteria. These studies were conducted from 2003 to 2023 and analyzed data from 19,787 clinical isolates of H. influenzae. The results showed different levels of resistance of H. influenzae to different antibiotics: ampicillin (36%), azithromycin (15.3%), ceftriaxone (1.4%), etc. The global prevalence for beta-lactamases producing H. influenzae and MDR H. influenzae was measured 34.9% and 23.1%, respectively. The prevalence rate of MDR H. influenzae was higher in Asian countries (24.6%) compared to Western regions (15.7%). MDR H. influenzae had the highest prevalence in meningitis cases (46.9%) and the lowest prevalence in acute otitis media (0.5%). Conclusions The prevalence of MDR H. influenzae has been increasing worldwide, especially in Asian regions. This highlights the urgent need for monitoring and implementation of effective antibiotic stewardship programs globally.
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112
Monitoring SARS-CoV-2 genetic variability: A post-market surveillance workflow for combined bioinformatic and laboratory evaluation of commercial RT-PCR assay performance
Barbara Kosińska-Selbi, Justyna Kowalczyk, Jagoda Pierscińska, Jarosław Wełeszczuk, Luis Peñarrubia, Benjamin Turner, Josep Pareja, Roberto Porco, Rubi Diaz-Hernandez, Martí Juanola-Falgarona, Melisa Rey, Davide Manissero, Anna Blacha
PLoS One Infectious Diseases, 12.01.2024
Tilføjet 12.01.2024
by Barbara Kosińska-Selbi, Justyna Kowalczyk, Jagoda Pierscińska, Jarosław Wełeszczuk, Luis Peñarrubia, Benjamin Turner, Josep Pareja, Roberto Porco, Rubi Diaz-Hernandez, Martí Juanola-Falgarona, Melisa Rey, Davide Manissero, Anna Blacha Objective The speed at which Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is mutating has made it necessary to frequently assess how these genomic changes impact the performance of diagnostic real-time polymerase chain reaction (RT-PCR) assays. Herein, we describe a generic three-step workflow to assess the effect of genomic mutations on inclusivity and sensitivity of RT-PCR assays. Methods Sequences collected from the Global Initiative on Sharing All Influenza Data (GISAID) were mapped to a SARS-CoV-2 reference genome to evaluate the position and prevalence of mismatches in the oligonucleotide-binding sites of the QIAstat-Dx, an RT-PCR panel designed to detect SARS-CoV-2. The frequency of mutations and their impact on melting temperature were assessed, and sequences flagged by risk-based criteria were examined in vitro. Results Out of 8,900,393 SARS-CoV-2 genome sequences analyzed, only 173 (0.0019%) genomes contained potentially critical mutations for the QIAstat-Dx; follow-up in-vitro testing confirmed no impact on the assays’ performance. Conclusions The current study demonstrates that SARS-CoV-2 genetic variants do not affect the performance of the QIAstat-Dx device. It is recommended that manufacturers incorporate this workflow into obligatory post-marketing surveillance activities, as this approach could potentially enhance genetic monitoring of their product.
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113
Program Offering Free COVID-19 and Flu Services Expands Nationwide
Journal of the American Medical Association, 12.01.2024
Tilføjet 12.01.2024
The Home Test to Treat program—a public health effort funded by the US National Institutes of Health—is now open to adults around the country after being piloted in select locations earlier this year, the agency announced. It’s the first public health program that provides at-home testing for both COVID-19 and influenza on a national scale.
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114
Effects of scheduled school breaks on the circulation of influenza in children, school-aged population and adults in China: a spatio-temporal analysis
Mengling Qiao, Fuyu Zhu, Junru Chen, You Li, Xin Wang
International Journal of Infectious Diseases, 11.01.2024
Tilføjet 11.01.2024
School break / closure has been widely used as a non-pharmaceutical intervention (NPI) to mitigate severe epidemics and pandemics of respiratory infectious diseases, e.g., influenza and COVID-19. While school break has been reported to reduce the overall spread of respiratory infectious diseases [1-6], it could disproportionally affect certain population subgroups, e.g., students, which in turn reshape the epidemiology of respiratory infectious diseases in the broader population. Empirical contact data in a number of countries reveal compensatory contact behaviours during school closure compared with school term [7-9].
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115
Expression of Concern: Split inactivated COBRA vaccine elicits protective antibodies against H1N1 and H3N2 influenza viruses
The PLOS ONE Editors
PLoS One Infectious Diseases, 11.01.2024
Tilføjet 11.01.2024
116
Cost‐effectiveness analysis of cell‐based versus egg‐based quadrivalent influenza vaccines in the pediatric population in Taiwan
Chia‐Yu Chi, Ming‐Fang Cheng, Karam Ko, Joaquin F. Mould, Chih‐Jung Chen, Yhu‐Chering Huang, Ping‐Ing Lee
Journal of Medical Virology, 10.01.2024
Tilføjet 10.01.2024
117
Characterising respiratory infections among hospitalised children during the COVID-19 pandemic in southeastern China: a cross-sectional study of pathogens and clinical association
Huang, H., Wu, B., Lin, W.
BMJ Open, 10.01.2024
Tilføjet 10.01.2024
ObjectiveChildren with acute respiratory tract infections (ARTIs) pose significantly burden on healthcare facilities due to high hospitalisation rates and mortality. However, limited epidemiological and clinical characteristics data on ARTIs in southeastern China during the COVID-19 pandemic exists. DesignCross-sectional. SettingTertiary hospital associated with the First Affiliated Hospital, Fujian Medical University, China. Participants1007 hospitalised children diagnosed with ARTIs, aged 30 days to 15 years, were enrolled in this study from 1 January 2020 to 31 December 2021. Outcome measureThe primary outcomes are the rate of pathogen infections in children with ARTIs. Secondary outcomes are the description of risk factors associated with ARTIs in children. ResultsOf the 1007 enrolled children, 28.2%, 42.2%, 21.8% and 7.7% were diagnosed with upper respiratory tract infection, bronchopneumonia, bronchitis and pneumonia, respectively. Mycoplasma pneumoniae (MP) was the most prevalent pathogen (31.9%), followed by influenza B virus (IFVB; 29.1%) and influenza A virus (IFVA; 19.1%). The study found that children under 1 year old (older than 30 days: ORIFVB=12.50; ORMP=8.53), children aged 1–3 years (ORMP=1.62), the winter season (ORIFVA=1.36), the time from symptoms onset to hospitalisation (ORMP=1.10) and increased precipitation (ORLP=1.01) were high-risk factors for ARTIs. ConclusionThis investigation offers significant insights into the prevalence and distribution of common pathogens among children experiencing ARTIs in the context of the COVID-19 pandemic. The discernment of high-risk factors linked to these pathogens enhances our understanding of the epidemiological characteristics of ARTIs in children.
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118
Highly pathogenic avian influenza H5N1 virus infection of companion animals
Hinh LyDepartment of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA
Virulence, 8.01.2024
Tilføjet 8.01.2024
119
Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients
Journal of Infectious Diseases, 5.01.2024
Tilføjet 5.01.2024
Abstract Background Avian influenza viruses pose significant risk to human health. Vaccines targeting the hemagglutinin of these viruses are poorly immunogenic without the use of adjuvants.Methods Twenty healthy men and women (18-49 years of age) were randomized to receive two doses of inactivated influenza A/H5N1 vaccine alone (IIV) or with AS03 adjuvant (IIV-AS03) one month apart. Urine and serum samples were collected on day 0 and on days 1, 3, and 7 following first vaccination and subjected to metabolomics analyses to identify metabolites, metabolic pathways, and metabolite clusters associated with immunization.Results Seventy-three differentially abundant (DA) serum and 88 urine metabolites were identified for any post-vaccination day comparison. Pathway analysis revealed enrichment of tryptophan, tyrosine and nicotinate metabolism in urine and serum among IIV-AS03 recipients. Increased urine abundance of 4-vinylphenol sulfate on Day 1 was associated with serologic response based on hemagglutination inhibition responses. In addition, 9 DA urine metabolites were identified in participants with malaise compared to those without.Conclusions Our findings suggest that tryptophan, tyrosine, and nicotinate metabolism are upregulated among IIV-AS03 recipients compared with IIV alone. Metabolites within these pathways may serve as measures of immunogenicity and may provide mechanistic insights for adjuvanted vaccines.
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120
Recombinant duck enteritis virus bearing the hemagglutinin genes of H5 and H7 influenza viruses is an ideal multivalent live vaccine in ducks
Yubo ZhaoPucheng ChenYuzhen HuJing LiuYongping JiangXianying ZengGuohua DengJianzhong ShiYanbing LiGuobin TianJinxiong LiuHualan Chena State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of Chinab National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
Emerg Microbes Infect, 5.01.2024
Tilføjet 5.01.2024
121
Evolution and biological characterization of H5N1 influenza viruses bearing the clade 2.3.2.1 hemagglutinin gene
Xin XingJianzhong ShiPengfei CuiCheng YanYaping ZhangYuancheng ZhangCongcong WangYuan ChenXianying ZengGuobin TianLiling LiuYuntao GuanChengjun LiYasuo SuzukiGuohua DengHualan Chena State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of Chinab Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, People’s Republic of Chinac Institute of Western Agriculture, CAAS, Changji, People’s Republic of Chinad National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of Chinae Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
Emerg Microbes Infect, 5.01.2024
Tilføjet 5.01.2024
122
Reducing Diagnostic Bias Through Multiplex Polymerase Chain Reaction (PCR) Testing for SARS-CoV-2, Influenza A/B, and RSV
Clinical Infectious Diseases, 4.01.2024
Tilføjet 4.01.2024
123
Outcomes of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant, Influenza, and Respiratory Syncytial Virus on the Dissecting Table: Is Further Dissection Required?
Clinical Infectious Diseases, 4.01.2024
Tilføjet 4.01.2024
To the Editor—We read with interest the article by Hedberg et al that describes the differences in disease severity and outcomes following infections with the severe acute respiratory syndrome coronavirus 2 Omicron variant, influenza, and respiratory syncytial virus (RSV) among adult outpatients and inpatients [1]. The article provided important information and indicated that the Omicron variant is associated with worse outcomes compared with RSV and influenza. We would like to offer some insights that we believe could further enhance the comprehension and context of the study’s findings.
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124
The chemokine receptor CXCR3 promotes CD8+ T cell–dependent lung pathology during influenza pathogenesis
Kai Guo, Dan J. K. Yombo, Zhihan Wang, Zahrasadat Navaeiseddighi, Jintao Xu, Taylor Schmit, Nassem Ahamad, Jitendra Tripathi, Bony De Kumar, Ramkumar Mathur, Junguk Hur, Jie Sun, Michal A. Olszewski, Nadeem Khan
Science Advances, 4.01.2024
Tilføjet 4.01.2024
125
WHO: Surge in Respiratory Infections in China Not Due to New Pathogens
Journal of the American Medical Association, 3.01.2024
Tilføjet 3.01.2024
Respiratory illnesses—including Mycoplasma pneumoniae pneumonia, respiratory syncytial virus (RSV), and influenza—have been on the rise among children in China over the past several months.
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126
NSAID prescribing and adverse outcomes in common infections: a population-based cohort study
Stuart, B., Venekamp, R., Hounkpatin, H., Wilding, S., Moore, M., Little, P., Gulliford, M. C.
BMJ Open, 3.01.2024
Tilføjet 3.01.2024
ObjectivesInfections in primary care are often treated with non-steroidal anti-inflammatory drugs (NSAIDs). This study evaluates whether NSAID prescribing is associated with adverse outcomes for respiratory (RTIs) or urinary track (UTI) infections. ObjectivesTo determine whether there is an association between NSAID prescribing and the rate of adverse outcomes for infections for individual consulting in primary care. DesignCohort study of electronic health records. Setting87 general practices in the UK Clinical Practice Research Datalink GOLD. Participants142 925 patients consulting with RTI or UTI. Primary and secondary outcome measuresRepeat consultations, hospitalisation or death within 30 days of the initial consultation for RTI or UTI. Poisson models estimated the associations between NSAID exposure and outcome. Rate ratios were adjusted for gender, age, ethnicity, deprivation, antibiotic use, seasonal influenza vaccination status, comorbidities and general practice. Since prescribing variations by practice are not explained by case mix—hence, less impacted by confounding by indication—both individual-level and practice-level analyses are included. ResultsThere was an increase in hospital admission/death for acute NSAID prescriptions (RR 2.73, 95% CI 2.10 to 3.56) and repeated NSAID prescriptions (6.47, 4.46–9.39) in RTI patients, and for acute NSAID prescriptions for UTI (RR 3.03; 1.92 to 4.76). Practice-level analysis, controlling for practice population characteristics, found that for each percentage point increase in NSAID prescription, the percentages of hospital admission/death within 30 days increased by 0.32 percentage points (95% CI 0.16 to 0.47). ConclusionsIn this non-randomised study, prescription of NSAIDs at consultations for RTI or UTIs in primary care is infrequent but may be associated with increased risk of hospital admission. This supports other observational and limited trial data that NSAID prescribing might be associated with worse outcomes following acute infection and should be prescribed with caution.
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127
Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin
Joel FinneyAnnie Park MosemanSusan KongAkiko WatanabeShengli SongRichard M. WalshMasayuki KuraokaRyutaro KotakiE. Ashley MosemanKevin R. McCarthyDongmei LiaoXiaoe LiangXiaoyan NieOlivia LavidorRichard AbbottStephen C. HarrisonGarnett KelsoeaLaboratory of Molecular Medicine, Children’s Hospital, Harvard Medical School, Boston, MA 02115bDepartment of Integrative Immunobiology, Duke University, Durham, NC 27710cDepartment of Surgery, Duke University, Durham, NC 27710dThe Harvard Cryo-Electron Microscopy (Cryo-EM) Center for Structural Biology, Harvard Medical School, Boston, MA 02115eDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115fCenter for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261gHHMI, Boston, MA 02115hDuke Human Vaccine Institute, Duke University, Durham, NC 27710
Proceedings of the National Academy of Sciences, 3.01.2024
Tilføjet 3.01.2024
128
[Editorial] Patterns of respiratory infections after COVID-19
The Lancet Respiratory Medicine
Lancet Respiratory Medicine, 3.01.2024
Tilføjet 3.01.2024
Changing patterns of respiratory infections have been seen again in 2024. Disease incidence shifted during the COVID-19 pandemic due to lockdowns and social distancing, which slowed down pathogen circulation and the development of immunity at a population level. Influenza and RSV have settled into a more traditional pattern this year, but tuberculosis and pneumonia incidence remains unusual.
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129
Epidemiological trends of respiratory tract pathogens detected via mPCR in Australian adult patients before COVID-19
BMC Infectious Diseases, 2.01.2024
Tilføjet 2.01.2024
Abstract Background Respiratory tract infections (RTIs) are a major global health burden due to their high morbidity and mortality. This retrospective study described the epidemiology of respiratory pathogens in adults over a 5-year period at an Australian tertiary healthcare network. Methods All multiplex reverse transcription polymerase chain reaction respiratory samples taken between the 1st of November 2014 and the 31st of October 2019 were included in this study. Overall prevalence and variations according to seasons, age groups and sex were analysed, as well as factors associated with prolonged hospital and intensive care length of stay. Results There were 12,453 pathogens detected amongst the 12,185 positive samples, with coinfection rates of 3.7%. Picornavirus (Rhinovirus), Influenza A and respiratory syncytial virus were the most commonly detected pathogens. Mycoplasma pneumoniae was the most commonly detected atypical bacteria. Significant differences in the prevalence of Chlamydia pneumoniae and Human metapneumovirus infections were found between sexes. Longest median length of intensive care and hospital stay was for Legionella species. Seasonal variations were evident for certain pathogens. Conclusions The high rates of pathogen detection and hospitalisation in this real-world study highlights the significant burden of RTIs, and the urgent need for an improved understanding of the pathogenicity as well as preventative and treatment options of RTIs.
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130
Severe pneumonia with co-infection of H5N1 and SARS-CoV-2: a case report
BMC Infectious Diseases, 2.01.2024
Tilføjet 2.01.2024
Abstract Background The H5N1 influenza virus is a cause of severe pneumonia. Co-infection of influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to poor prognosis of patients during the COVID-19 epidemic. However, reports on patients co-infected with avian influenza virus and SARS-CoV-2 are scarce. Case presentation A 52-year-old woman presented with a fever, which has persisted for the past eight days, along with worsening shortness of breath and decreased blood pressure. Computed tomography (CT) revealed an air bronchogram, lung consolidation, and bilateral pleural effusion. The subsequent polymerase chain reaction (PCR) of the bronchoalveolar lavage fluid (BALF) revealed positivity for H5N1 and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Conclusion The H5N1 influenza virus is a cause of severe pneumonia. The clinical presentation of the patient had a predomination of H5N1 influenza rather than COVID-19. A PCR analysis for the identification of the virus is necessary to reveal the pathogen causing the severe pneumonia. The patient exhibited an excellent prognosis upon the use of the appropriate antiviral medicine.
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131
Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis
Antonio E. Pontiroli, Francesco Scovenna, Valentina Carlini, Elena Tagliabue, Jimmy Martin‐Delgado, Lucia La Sala, Elisabetta Tanzi, Ivan Zanoni
Journal of Medical Virology, 2.01.2024
Tilføjet 2.01.2024
132
A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage
Dexin KongYanjuan HeJiaxin WangLanyan ChiXiang AoHejia YeWeihong QiuXiutong ZhuMing LiaoHuiying Fana College of Veterinary Medicine, South China Agricultural University, Guangzhou, People’s Republic of Chinab Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, People’s Republic of Chinac Key Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture and Rural Affairs, Guangzhou, People’s Republic of Chinad National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangzhou, People’s Republic of Chinae Guangzhou South China Biological Medicine Co., Ltd, Guangzhou, People’s Republic of China
Emerg Microbes Infect, 31.12.2023
Tilføjet 31.12.2023
133
Influenza viral infection is a risk factor for severe illness in COVID-19 patients: a nationwide population-based cohort study
Jeong-Hwan HwangYeon Seok YouSang Woo YeomMin Gyu LeeJong-hwan LeeMin Gul KimJong Seung Kima Department of Internal Medicine, Division of Infectious Diseases, Jeonbuk National University Medical School, Jeonju, South Koreab Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Koreac Department of Medical Informatics, Jeonbuk National University, Jeonju, South Koread Department of Otorhinolaryngology, Jeonbuk National University Medical School, Jeonju, South Koreae Department of Pharmacology, Jeonbuk National University Medical School, Jeonju, South Korea
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
134
Risk assessment of the newly emerged H7N9 avian influenza viruses
Pengxiang ChangJean-Remy SadeyenSushant BhatRebecca DainesAltaf HussainHuseyin YilmazMunir Iqbala The Pirbright Institute, Woking, UKb Department of Virology, Veterinary Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
135
Cross-species infection potential of avian influenza H13 viruses isolated from wild aquatic birds to poultry and mammals
Weiyang SunMenglin ZhaoZhijun YuYuanguo LiXinghai ZhangNa FengTiecheng WangHongmei WangHongbin HeYongkun ZhaoSongtao YangXianzhu XiaYuwei Gaoa Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Chang’chun, People’s Republic of Chinab Poultry Institute, Shandong Academy of Agricultural Sciences, Ji’nan, People’s Republic of Chinac Key Laboratory of Animal Resistant Biology of Shandong, Ruminant Disease Research Center, College of Life Science, Shandong Normal University, Ji’nan, People’s Republic of Chinad Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yang’zhou, People’s Republic of China
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
136
Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses
Sathya N. Thulasi RamanAdrian ZetnerAnwar M. HashemDevina PatelJianguo WuCaroline GravelJun GaoWanyue ZhangAnnabelle PfeifleLevi TammingKaran ParikhJingxin CaoRoger TamDavid SafronetzWangxue ChenMichael J.W. JohnstonLisheng WangSimon SauveMichael Rosu-MylesGary Van DomselaarXuguang Lia Centre for Oncology and Regulatory Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, Canadab National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canadac Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabiad Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabiae Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Canadaf Department of Chemistry, Carleton University, Ottawa, Canadag Centre for Vaccines Clinical Trials and Biostatistics, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, Canadah Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
137
Reciprocal enhancement of SARS-CoV-2 and influenza virus replication in human pluripotent stem cell-derived lung organoids
Min Jung KimSumi KimHeeyeon KimDayeon GilHyeong-Jun HanRajesh K. ThimmulappaJang-Hoon ChoiJung-Hyun Kima Division of Intractable Diseases Research, Department of Chronic Diseases Convergence Research, Korea National Institute of Health, Cheongju, Koreab Korea National Stem Cell Bank, Cheongju, South Koreac Division of Acute Viral Disease, Center for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Cheongju, Koread Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, India
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
138
Cell-intrinsic genomic reassortment of pandemic H1N1 2009 and Eurasian avian-like swine influenza viruses results in potentially zoonotic variants
Verónica A. FerrandoMarcel E. FriedrichShrey GandhiAlexander MellmannDörthe MasemannAnmari ChristerssonDarisuren AnhlanLinda BrunotteMonika StollTimm HarderMartin BeerYvonne BoergelingStephan Ludwiga Institute of Virology Münster, Westfälische Wilhelms-University, Münster, Germanyb Department of Genetic Epidemiology, Institute of Human Genetics, Westfälische Wilhelms-University, Münster, Germanyc Institute of Hygiene Münster, Westfälische Wilhelms-University, Münster, Germanyd Institute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald, Germany
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
139
Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
Zhen WangHongkui LiYuhan LiZhuanli WuHui AiMing ZhangLibin RongMichael L. BlinovQi TongLitao LiuHonglei SunJuan PuWenhai FengJinhua LiuYipeng Suna National Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of Chinab State Key Laboratories of Agrobiotechnology, and Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of Chinac Liaoning Agricultural Development Service Center, Shenyang, People’s Republic of Chinad Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, USAe Department of Mathematics, University of Florida, Gainesville, FL, USAf Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, CT, USA
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
140
Genetic, biological and epidemiological study on a cluster of H9N2 avian influenza virus infections among chickens, a pet cat, and humans at a backyard farm in Guangxi, China
Jing YangJianhua YanCheng ZhangShanqin LiManhua YuanChunge ZhangChenguang ShenYang YangLifeng FuGuanlong XuWeifeng ShiZhenghai MaTing Rong LuoYuhai Bia CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, People’s Republic of Chinab Laboratory of Animal Infectious Diseases, Medical College & College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, People’s Republic of Chinac College of Life Science and Technology, Xinjiang University, Urumchi, People’s Republic of Chinad Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital, Shenzhen, People’s Republic of Chinae School of Public Health, Southern Medical University, Guangzhou, People’s Republic of Chinaf China Institute of Veterinary Drug Control, Beijing, People’s Republic of Chinag Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People’s Republic of Chinah University of Chinese Academy of Sciences, Beijing, People’s Republic of China
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
141
Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China
Xiaohao XuQi ChenMin TanJia LiuXiyan LiLei YangYuelong ShuDayan WangWenfei Zhua School of Public Health (Shenzhen), Sun Yat-sen University, Guangdong, People’s Republic of Chinab National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention; WHO Collaborating Center for Reference and Research on Influenza; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, People’s Republic of Chinac Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
142
Influenza vaccination is associated with a reduced risk of invasive aspergillosis in high-risk individuals in Taiwan: a population-based cohort study
Yi-Jyun ChenI-Feng LinJen-Hsiang ChuangHung-Ling HuangTa-Chien Chana Institute of Public Health, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwanb Centers for Disease Control, Taipei, Taiwanc Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung, Taiwand Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwane Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwanf Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwang Research Center for Humanities and Social Sciences, Academia Sinica, Taipei, Taiwan
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
143
Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages
Hongjie XiaJason YeungBirte KalveramCody J. BillsJohn Yun-Chung ChenChaitanya KurhadeJing ZouSteven G. WidenBrian R. MannRebecca KondorC. Todd DavisBin ZhouDavid E. WentworthXuping XiePei-Yong Shia Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USAb Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USAc Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USAd Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USAe Sealy, Institute for Drug Discovery, University of Texas Medical Branch, Galveston, TX, USAf Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USAg Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USAh Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
144
Prevalence, evolution, replication and transmission of H3N8 avian influenza viruses isolated from migratory birds in eastern China from 2017 to 2021
Yanwen WangMengjing WangHong ZhangConghui ZhaoYaping ZhangJinyan ShenXiaohong SunHongke XuYujiao XieXinxin GaoPengfei CuiDong ChuYubao LiWenqiang LiuPeng PengGuohua DengJing GuoXuyong Lia College of Agronomy, Liaocheng University, Liaocheng, People’s Republic of Chinab Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin, People’s Republic of Chinac Biological Disaster Control and Prevention Center, National Forestry and Grassland Administration, Shenyang, People’s Republic of China
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
145
Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence
Ning MaZhi-Wu XiaZhe-Gang ZhangXuan-Xuan NianXue-Dan LiZheng GongGuo-Mei ZhangYang LeRong ZhouJia-You ZhangXiao-Ming Yanga National Engineering Technology Research Center for Combined Vaccines, Wuhan, People’s Republic of Chinab The Second Laboratory of Viral Vaccine Research, Wuhan Institute of Biological Products Co. Ltd., Wuhan, People’s Republic of Chinac School of Animal Science and Technology, School of Animal Medicine, Huazhong Agricultural University, Wuhan, People’s Republic of Chinad China National Biotec Group Company Limited, Beijing, People’s Republic of China
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
146
Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens
Jung-Hoon KwonKateri BertranDong-Hun LeeMiria Ferreira CriadoLindsay KillmasterMary J. Pantin-JackwoodDavid E. Swaynea Agricultural Research Service, U.S. Department of Agriculture, U.S. National Poultry Research Center, Athens, GA, USAb College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Koreac Unitat mixta d’Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Bellaterra, Spaind IRTA. Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Bellaterra, Spaine College of Veterinary Medicine, Konkuk University, Seoul, Republic of Koreaf Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
147
Highly pathogenic avian influenza H5N1 virus outbreak among Cape cormorants (Phalacrocorax capensis) in Namibia, 2022
Umberto MoliniJohn YabeIrene K. MekiHatem Ouled Ahmed Ben AliTirumala B. K. SettypalliSneha DattaLauren Michelle CoetzeeEllini HamunyelaSiegfried KhaisebGiovanni CattoliCharles E. LamienWilliam G. Dundona School of Veterinary Medicine, Faculty of Health Sciences and Veterinary Medicine, University of Namibia, Windhoek, Namibiab Central Veterinary Laboratory (CVL), Windhoek, Namibiac Animal Production and Health Laboratory, Animal Production and Health Section, Department of Nuclear Sciences and Applications, Joint FAO/IAEA Division, International Atomic Energy Agency, Vienna, Austria
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
148
Emerging triple-reassortant influenza C virus with household-associated infection during an influenza A(H3N2) outbreak, China, 2022
Lan CaoYing LuChaojun XieYiyun ChenLijun LiangTengfei ZhouZiyi ZengChen WenBiao DiBaisheng LiKuibiao LiZhoubin Zhanga Institute of Public Health, Guangzhou Medical University and Guangzhou Center for Disease Control and Prevention, Guangzhou, People’s Republic of Chinab Huadu District Center for Disease Control and Prevention, Guangzhou, People’s Republic of Chinac Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, People’s Republic of China
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
149
Alarming situation of emerging H5 and H7 avian influenza and effective control strategies
Jianzhong ShiXianying ZengPengfei CuiCheng YanHualan Chena Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, People’s Republic of Chinab State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, People’s Republic of China
Emerg Microbes Infect, 30.12.2023
Tilføjet 30.12.2023
150
A Multi-Season Randomised Controlled Trial of Advax-Adjuvanted Seasonal Influenza Vaccine in Participants with Chronic Disease or Older Age
Journal of Infectious Diseases, 29.12.2023
Tilføjet 29.12.2023
Abstract Background The aim of this study was to determine the safety and immunogenicity of trivalent inactivated influenza vaccine (TIV) alone or formulated with Advax™ delta inulin adjuvant in those of older age (> 60 years) or with chronic disease.Methods Over four consecutive years from 2008-2011, adult participants with chronic disease or over 60 years were recruited into a randomised controlled study to assess the safety, tolerability and immunogenicity of Advax-adjuvanted versus standard TIV. The per protocol (PP) population with at least one post-baseline measurement of influenza antibodies comprised 1297 participants: 447 in the TIV, and 850 in the Advax-adjuvanted TIV, groups.Results No safety issues were identified. Variables negatively affecting vaccine responses included obesity and diabetes mellitus. Advax adjuvant had a positive impact on anti-influenza IgM responses and on H3N2 and B strain seropositivity as assessed by hemagglutination inhibition.Conclusions Advax-adjuvanted TIV was safe and well tolerated in individuals with chronic disease. There is an ongoing need for research into improved influenza vaccines for high-risk populations. Australia New Zealand Clinical Trial Registry: ACTRN 12608000364370.
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