Dansk Selskab for Infektionsmedicin
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Sidst opdateret 24.11.2018
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1 A Precaution About PrEP in HIV Prevention
Medscape Infectious Diseases Headlines, 12.11.2018
Tilføjet 13.11.2018 23:21
PrEP can reduce new HIV infections if taken as directed. So why do PrEP failures occur?
2 An early start of West Nile virus seasonal transmission: the added value of One Heath surveillance in detecting early circulation and triggering timely response in Italy, June to July 2018
Eurosurveillance: Most Recent Articles, 9.08.2018
Tilføjet 10.08.2018 07:54
Flavia Riccardo, Federica Monaco, Antonino Bella, Giovanni Savini, Francesca Russo, Roberto Cagarelli, Michele Dottori, Caterina Rizzo, Giulietta Venturi, Marco Di Luca, Simonetta Pupella, Letizia Lombardini, Patrizio Pezzotti, Patrizia Parodi, Francesco Maraglino, Alessandro Nanni Costa, Giancarlo Maria Liumbruno, Giovanni Rezza and the working group
In Italy, the 2018 West Nile virus transmission season started early with a high number of cases reported. One-Health surveillance, within the Italian West Nile national preparedness and response plan, detected viral circulation 9 days before symptom-onset of the first confirmed human case; triggering timely implementation of blood and transplant safety measures. This is an example of how functional coordination allows health authorities to use early warning triggers from surveillance systems to implement preventive measures.
3 Cost-effectiveness and budget effect of pre-exposure prophylaxis for HIV-1 prevention in Germany from 2018 to 2058
Eurosurveillance: Most Recent Articles, 14.02.2019
Tilføjet 15.02.2019 06:38
David A M C van de Vijver, Ann-Kathrin Richter, Charles A B Boucher, Barbara Gunsenheimer-Bartmeyer, Christian Kollan, Brooke E Nichols, Christoph D Spinner, Jürgen Wasem, Knud Schewe and Anja Neumann
Background
Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention strategy for men-who-have-sex-with-men (MSM). The high cost of PrEP has until recently been a primary barrier to its use. In 2017, generic PrEP became available, reducing the costs by 90%.
Aim
Our objective was to assess cost-effectiveness and costs of introducing PrEP in Germany.
Methods
We calibrated a deterministic mathematical model to the human immunodeficiency virus (HIV) epidemic among MSM in Germany. PrEP was targeted to 30% of high-risk MSM. It was assumed that PrEP reduces the risk of HIV infection by 85%. Costs were calculated from a healthcare payer perspective using a 40-year time horizon starting in 2018.
Results
PrEP can avert 21,000 infections (interquartile range (IQR): 16,000–27,000) in the short run (after 2 years scale-up and 10 years full implementation). HIV care is predicted to cost EUR 36.2 billion (IQR: 32.4–40.4 billion) over the coming 40 years. PrEP can increase costs by at most EUR 150 million within the first decade after introduction. Ten years after introduction, PrEP can become cost-saving, accumulating to savings of HIV-related costs of EUR 5.1 billion (IQR: 3.5–6.9 billion) after 40 years. In a sensitivity analysis, PrEP remained cost-saving even at a 70% price reduction of antiretroviral drug treatment and a lower effectiveness of PrEP.
Conclusion
Introduction of PrEP in Germany is predicted to result in substantial health benefits because of reductions in HIV infections. Short-term financial investments in providing PrEP will result in substantial cost-savings in the long term.
4 Development of a public health emergency preparedness competency model for European Union countries
Eurosurveillance: Most Recent Articles, 6.12.2018
Tilføjet 07.12.2018 09:24
Michael A. Stoto, Elena Savoia, Christopher Nelson, Rachael Piltch-Loeb, Stefano Guicciardi, Judit Takacs, Carmen Varela Santos and Massimo Ciotti
In 2017, the European Centre for Disease Prevention and Control (ECDC) developed a competency model for individuals who work in public health emergency preparedness (PHEP) in European Union (EU) countries. The model serves as the basis for developing competency-based training programmes to support professionals in PHEP efforts at the country level. The competency model describes the knowledge and skills professionals need when working in national-level PHEP, such as preparedness committee members or their equivalents. In order to develop the model, existing competency statements were reviewed, as well as case studies and reports. Fifty-three professionals from the EU and other countries provided feedback to the model by participating in a three-stage consultation process. The model includes 102 competency, 100 knowledge and 158 skill statements. In addition to specifying the appropriate content for training programmes, the proposed common competency model can help to standardise terminology and approaches to PHEP training.
5 Everything You Need to Know About Shingrix
Medscape Infectious Diseases Headlines, 30.04.2018
Tilføjet 30.04.2018 17:34
Patients are asking for Shingrix. Know the important facts about storage, preparation, and administration, and what patients should be told before they receive this vaccine.
6 Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks
Eurosurveillance: Most Recent Articles, 31.01.2019
Tilføjet 01.02.2019 06:30
Barbara Bartolini, Cesare EM Gruber, Marion Koopmans, Tatjana Avšič, Sylvia Bino, Iva Christova, Roland Grunow, Roger Hewson, Gulay Korukluoglu, Cinthia Menel Lemos, Ali Mirazimi, Anna Papa, Maria Paz Sanchez-Seco, Aisha V. Sauer, Hervè Zeller, Carla Nisii, Maria Rosaria Capobianchi, Giuseppe Ippolito, Chantal B. Reusken and Antonino Di Caro
Background
Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks.
Aims
To review scientific literature and collect experts’ opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans.
Methods
We conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVD-LabNet (Emerging Viral Diseases-Expert Laboratory Network).
Results
Consensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin.
Conclusion
No effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses.
7 PRO/AH/EDR> Ebola update (12): Congo DR (NK, IT) cases, summaries, preparedness, treatment
HealthMap Global Disease Alerts, 31.01.2019
Tilføjet 01.02.2019 08:05
ProMED Mail
Ebola -- DR Congo- Since the beginning of vaccination on 8 Aug 2018, 69 827 people have been vaccinated, including 20 241 in Beni, 16 390 in Katwa, 7860 in Butembo, 6008 in Mabalako, 2626 in Kalunguta, 2080 in Komanda, 1911 in Goma, 1755 in Oicha, 1663 in Mandima, 1157 in Karisimbi, 877 in Vuhovi, 873 in Kayina, 842 in Kyondo, 750 in Masereka, 700 in Lubero, 599 in Mutwanga, 560 in Rutshuru, 527 in Nyankunde, 524 in Biena, 442 in Musienene, 434 in Bunia, 355 to Tchomia, 167 to Kirotshe, 125 to Nyiragongo, 114
Ebola update (12): Congo DR (NK, IT) cases, summaries, preparedness, treatment" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Fwww.infmed.dk%2Fudbrud%3Frss_filter%3Dprep%26setpoint%3D80572%23108562">
8 PRO/AH/EDR> Ebola update (13): Congo DR (NK, IT) cases, summary, assessment, preparedness
HealthMap Global Disease Alerts, 3.02.2019
Tilføjet 03.02.2019 07:38
ProMED Mail
Ebola -- DR Congo- Since the beginning of vaccination on 8 Aug 2018, 72 248 people have been vaccinated, including 24 435 in Beni [North Kivu], 17 527 in Katwa [North Kivu], 8099 in Butembo [North Kivu], 6008 in Mabalako [North Kivu], 2686 in Kalunguta [North Kivu], 2150 in Komanda [Ituri], 1981 in Goma [North Kivu], 1821 in Oicha [North Kivu], 1663 in Mandima [Ituri], 1157 in Karisimbi [North Kivu], 943 in Kayina [North Kivu], 877 in Vuhovi [North Kivu], 842 in Kyondo [North Kivu], 750 in Masereka [North
Ebola update (13): Congo DR (NK, IT) cases, summary, assessment, preparedness" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Fwww.infmed.dk%2Fudbrud%3Frss_filter%3Dprep%26setpoint%3D80572%23108760">
9 PRO/AH/EDR> Ebola update (144): Congo DR (NK, IT) cases, summary, concerns
HealthMap Global Disease Alerts, 5.12.2018
Tilføjet 05.12.2018 06:35
10 PRO/AH/EDR> Ebola Update (147): DR Congo (NK, IT) cases, preparedness
HealthMap Global Disease Alerts, 11.12.2018
Tilføjet 11.12.2018 03:46
ProMED Mail
Ebola -- DR CongoVaccination- Continued wide-belt vaccination (or ring plus) in Otomaber (in Komanda Health Zone) and Aloya (in Mabalako Health Zone)- Since vaccination began on 8 Aug 2018, 43 449 people have been vaccinated, including 18 441 in Beni, 6966 in Katwa, 4792 in Mabalako, 4096 in Butembo, 2092 in Kalunguta, 1663 in Mandima, 769 in Vuhovi, 750 in Masereka, 700 in Lubero, 633 in Komanda, 599 in Mutwanga, 521 in Oicha, 434 in Bunia, 355 in Tchomia, 274 in Musienene, 241 in Kyondo, and 63 in
Ebola Update (147): DR Congo (NK, IT) cases, preparedness" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Fwww.infmed.dk%2Fudbrud%3Frss_filter%3Dprep%26setpoint%3D80572%23103567">
11 PRO/AH/EDR> Ebola update (32): Congo DR, cases, preparation, research
HealthMap Global Disease Alerts, 11.06.2018
Tilføjet 12.06.2018 07:52
12 PRO/AH/EDR> Ebola update (40): Congo DR, cases, WHO, vaccine, treatment, preparedness
HealthMap Global Disease Alerts, 22.06.2018
Tilføjet 23.06.2018 02:29
13 PRO/AH/EDR> Ebola update (69): Congo DR (NK,IT) cases, Uganda NOT, WHO response
HealthMap Global Disease Alerts, 16.08.2018
Tilføjet 16.08.2018 17:14
ProMED Mail
Ebola -- DR CongoAccording to the latest situation report published by the WHO, a total of 990 contacts are under surveillance in Mabalako (790), Beni (141), and Mandima (59) health zones as of [11 Aug 2018]. Of these, 129 are healthcare workers. So far, 8 healthcare workers have contracted the virus, and 1 has died.Today [15 Aug 2018] the WHO detailed the surveillance and preparedness plans underway in the DRC and Uganda, South Sudan, Rwanda, and Burundi -- the countries most likely to experience
Ebola update (69): Congo DR (NK,IT) cases, Uganda NOT, WHO response" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Fwww.infmed.dk%2Fudbrud%3Frss_filter%3Dprep%26setpoint%3D80572%2395837">
14 PRO/AH/EDR> Ebola update (71): Congo DR (NK) cases, response, bats
HealthMap Global Disease Alerts, 19.08.2018
Tilføjet 19.08.2018 11:48
15 PRO/AH/EDR> Ebola update (88): Congo DR (NK) case update, preparedness, publications
HealthMap Global Disease Alerts, 14.09.2018
Tilføjet 14.09.2018 05:47
16 PRO/AH/EDR> Ebola update (99): Congo DR (NK, IT) case update, risk, preparedness, unrest
HealthMap Global Disease Alerts, 29.09.2018
Tilføjet 29.09.2018 17:19
17 PRO/AH/EDR> Feline panleukopenia - USA (02): (TN)
HealthMap Global Disease Alerts, 27.09.2018
Tilføjet 27.09.2018 23:32
18 PRO/AH/EDR> Hantavirus - Americas (41): USA (OR)
HealthMap Global Disease Alerts, 14.06.2018
Tilføjet 15.06.2018 07:33
19 PRO/AH/EDR> Ross River virus - Australia (02): (NS)
HealthMap Global Disease Alerts, 15.11.2018
Tilføjet 16.11.2018 03:44
20 PRO/AH/EDR> Salmonellosis, st. Agona - EU (02): cucumbers
HealthMap Global Disease Alerts, 31.07.2018
Tilføjet 01.08.2018 08:13
21 PRO/AH/EDR> Trypanosomiasis (Chagas disease) - Brazil (02): (PA) foodborne
HealthMap Global Disease Alerts, 25.08.2018
Tilføjet 25.08.2018 02:35
22 PRO/AH/EDR> Yellow fever - Africa (28): South Sudan (GB) WHO
HealthMap Global Disease Alerts, 23.12.2018
Tilføjet 23.12.2018 23:18
23 PRO/ALL> New in IJID (01): January 2019
HealthMap Global Disease Alerts, 4.01.2019
Tilføjet 05.01.2019 01:47
ProMED Mail
Monkeypox, Hepatitis B, Other Human Disease, Tuberculosis, Zika virus, HIV/AIDS, Rubella, Measles, MRSA, Crimean-Congo Hemorrhagic Fever, Chagas -- NigeriaEditorials and perspectivesMonkeypox -- Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication eraEskild Petersen, Ibrahim Abubakar, Chikwe Ihekweazu, David Heymann, Francine Ntoumi, Lucille Blumberg, Danny Asogun, Victor Mukonka, Swaib Abubaker Lule, Matthew Bates, Isobella Honeyborne, Sayoki Mfinanga, Peter Mwaba, Osman Dar, Francesco Vairo, Maowia Mukhtar, Richard Kock, Timothy D. McHugh, Giuseppe Ippolito,
New in IJID (01): January 2019" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Fwww.infmed.dk%2Fudbrud%3Frss_filter%3Dprep%26setpoint%3D80572%23105791">
24 PRO/ALL> New in IJID (07): July 2018
HealthMap Global Disease Alerts, 2.07.2018
Tilføjet 03.07.2018 08:24
ProMED Mail
-- Worldwide/UnknownPerspectivesEnhancing preparation for large nipah outbreaks beyond Bangladesh: preventing a tragedy like ebola in West AfricaInternational Journal of Infectious Diseases, Volume 72, July 2018, Pages 69-72Halsie Donaldson, Daniel Lucey A novel view on the pathogenesis of complications after intravesical BCG for bladder cancerInternational Journal of Infectious Diseases, Volume 72, July 2018, Pages 63-68Manu P. Bilsen, Krista E. van Meijgaarden, Hanna K. de Jong, Simone A.
New in IJID (07): July 2018" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Fwww.infmed.dk%2Fudbrud%3Frss_filter%3Dprep%26setpoint%3D80572%2393146">
25 PRO/EDR> Cyclosporiasis - USA (03): additional states
HealthMap Global Disease Alerts, 19.06.2018
Tilføjet 20.06.2018 05:12
26 PRO/EDR> HIV - Australia: (VI,NS) Decr. condom use & incr. PrEP in MSM, decr. infection
HealthMap Global Disease Alerts, 21.06.2018
Tilføjet 22.06.2018 04:31
27 PRO/EDR> Malaria - Paraguay: WHO certified malaria free
HealthMap Global Disease Alerts, 16.06.2018
Tilføjet 16.06.2018 20:09
28 PRO/EDR> Meningitis, meningococcal - Nigeria (04): fatal, serogroup C
HealthMap Global Disease Alerts, 31.12.2018
Tilføjet 01.01.2019 00:21
29 PRO/EDR> Typhoid fever - Fiji: (NT)
HealthMap Global Disease Alerts, 7.12.2018
Tilføjet 08.12.2018 00:04
30 Status, quality and specific needs of Ebola virus diagnostic capacity and capability in laboratories of the two European preparedness laboratory networks EMERGE and EVD-LabNet
Eurosurveillance: Most Recent Articles, 10.05.2018
Tilføjet 11.05.2018 07:37
Chantal B Reusken, Ramona Mögling, Pieter W Smit, Roland Grunow, Giuseppe Ippolito, Antonino Di Caro and Marion Koopmans
From December 2013 to March 2016, West Africa experienced the largest Ebola virus (EBOV) outbreak to date, leading to a European-wide activation of laboratory preparedness and response. At the end of the outbreak, laboratories associated with the two European preparedness networks of expert laboratories EMERGE JA and EVD-LabNet were invited to participate in an assessment of the response of European laboratories to the EBOV outbreak, to identify learning points and training needs to strengthen future outbreak responses. Response aspects assessed included diagnostics, biorisk management and quality assurance. The overall coverage of EBOV diagnostics in the European Union/European Economic Area (EU/EEA) was found to be adequate although some points for quality improvement were identified. These included the need for relevant International Organization for Standardization (ISO) accreditation, the provision of EBOV external quality assessments (EQA) in periods where there is no emergency, facilitating access to controls and knowledge, biorisk management without compromising biosafety and a rapid public health response, and the need for both sustained and contingency funding for preparedness and response activities.
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