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Roza Ernest, Nsiande Lema, Sued Yassin, Agricola Joachim, Mtebe Majigo
PLoS One Infectious Diseases, 6.05.2024
Tilføjet 6.05.2024
by Roza Ernest, Nsiande Lema, Sued Yassin, Agricola Joachim, Mtebe Majigo Background Urinary tract infections (UTI) are common in under-five children, with significant consequences leading to bacteremia, dehydration, kidney scarring, and renal failure. The incidence of UTI varies with patients’ demographics and geographic location. Limited studies have addressed UTI issues, particularly in children. We determined the proportion of UTI, bacterial aetiology, and antimicrobial susceptibility patterns and associated factors among under-five children at the district hospital between March and April 2023 Methods We conducted a cross-sectional study using a convenient non-probability sampling technique to collect urine samples from participants with signs and symptoms of UTI. Written informed consent was obtained from parents or guardians. We collected Participants’ information using a pretested structured questionnaire. Urine samples were processed at the Regional Referral Hospital. All analyses were conducted using STATA version 15.0. We determined the factors associated with UTI using a modified Poisson model multivariable analysis of the modified Poisson model. The results were presented as a prevalence ratio and 95% confidence interval. The level of significance was specified at 0.05. Result The study recruited 368 under-five children; 194 (52.7%) were males, and the median age (interquartile range) was 24 (13–36) months. Of all, 28.8% (95% CI-24.3–33.6) had culture-confirmed UTI. One hundred and six pathogens were isolated, the majority being Escherichia coli (E. coli), 37 (34.9%), and Staphylococcus aureus (S. aureus), 26 (24.5%). The susceptibility of E. coli to cefepime, piperacillin-tazobactam, nitrofurantoin, and meropenem ranged from 81.1% to 97.3%. S. aureus was most susceptible to nitrofurantoin (96.2%) and ciprofloxacin (92.3%). Multidrug resistance was observed in 33.0% of isolates. The proportion of Methicillin-resistant S. aureus and extended-spectrum beta-lactamases was 23.1% and 25%, respectively. UTI was observed more in patients presenting with vomiting, dysuria, and abdominal pain, patients below 24 months of age, nappy users, and uncircumcised males. Conclusion Our study found a relatively high proportion of UTI among under-five children associated with vomiting, dysuria, abdominal pain, nappy use, and uncircumcision in males. The pathogens were least susceptible to (trimethoprim-sulfamethoxazole, gentamycin, ampicillin, and penicillin) the commonly used antibiotic. We advocate a thorough clinical analysis to detect the predictors of UTI and a periodic review of empirical treatment of UTI based on the antibiotic susceptibility pattern.
Læs mere Tjek på PubMedDries De Witte, Ariel Alonso Abad, Thomas Neyens, Geert Verbeke, Geert Molenberghs
PLoS One Infectious Diseases, 6.05.2024
Tilføjet 6.05.2024
by Dries De Witte, Ariel Alonso Abad, Thomas Neyens, Geert Verbeke, Geert Molenberghs One of the key tools to understand and reduce the spread of the SARS-CoV-2 virus is testing. The total number of tests, the number of positive tests, the number of negative tests, and the positivity rate are interconnected indicators and vary with time. To better understand the relationship between these indicators, against the background of an evolving pandemic, the association between the number of positive tests and the number of negative tests is studied using a joint modeling approach. All countries in the European Union, Switzerland, the United Kingdom, and Norway are included in the analysis. We propose a joint penalized spline model in which the penalized spline is reparameterized as a linear mixed model. The model allows for flexible trajectories by smoothing the country-specific deviations from the overall penalized spline and accounts for heteroscedasticity by allowing the autocorrelation parameters and residual variances to vary among countries. The association between the number of positive tests and the number of negative tests is derived from the joint distribution for the random intercepts and slopes. The correlation between the random intercepts and the correlation between the random slopes were both positive. This suggests that, when countries increase their testing capacity, both the number of positive tests and negative tests will increase. A significant correlation was found between the random intercepts, but the correlation between the random slopes was not significant due to a wide credible interval.
Læs mere Tjek på PubMedMiso S. Park, SangSoo Park, Jie-Yoon Kang, In Chul Jung, HoRyong Yoo
PLoS One Infectious Diseases, 6.05.2024
Tilføjet 6.05.2024
by Miso S. Park, SangSoo Park, Jie-Yoon Kang, In Chul Jung, HoRyong Yoo Background Parkinson’s disease (PD) patients face a substantial unmet need for disease-modifying interventions. Potential approaches such as exercise and acupuncture have been investigated to slow PD progression. To address this unmet need, we developed a novel therapeutic approach that integrates acupuncture and exercise: the Meridian Activation Remedy System for PD patients (MARS-PD). Building upon promising outcomes observed in our preliminary pilot study, where MARS-PD exhibited a large clinically important difference on the Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III (MDS-UPDRS Part III), we embark on a randomized controlled trial with the primary objective of examining the efficacy, safety, and economic impact of MARS-PD. Methods In this single-center, assessor and statistician-blinded, parallel-group randomized controlled trial, we aim to investigate the clinical efficacy of MARS-PD through 16 interventions administered over 8 weeks in 88 PD patients. Participants will be randomly assigned to the experimental (n = 44) or control (n = 44) groups. The experimental group will receive MARS-PD intervention alongside standard care, while the control group will solely receive standard care. The intervention period spans 8 weeks, followed by a 12-week post-intervention follow-up. The primary endpoint is the change in MDS-UPDRS Part III score from baseline to the conclusion of the 8-week intervention. Secondary outcomes encompass various assessments, including MDS-UPDRS, International Physical Activity Questionnaire Short Form, Parkinson Self Questionnaire, Parkinson’s Disease Sleep Scale, Timed Up and Go test, GAITRite metrics, Functional Near-Infrared Spectroscopy measurements, smart band outcomes, gut microbiome analysis results, and iris connective tissue texture. Discussion Previous studies by the authors have indicated MARS-PD’s safety and benefits for PD patients. Building upon this foundation, our current study aims to provide a more comprehensive and detailed confirmation of the efficacy of MARS-PD. Trial registration cris.nih.go.kr KCT0006646 –First posted on 7 October 2021; ClinicalTrials.gov NCT05621772 –First posted on 11 November 2022.
Læs mere Tjek på PubMedReina Engle-Stone, K Ryan Wessells, Marjorie J. Haskell, Sika M. Kumordzie, Charles D. Arnold, Jennie N. Davis, Emily R. Becher, Ahmed D. Fuseini, Kania W. Nyaaba, Xiuping Tan, Katherine P. Adams, Georg Lietz, Stephen A. Vosti, Seth Adu-Afarwuah
PLoS One Infectious Diseases, 6.05.2024
Tilføjet 6.05.2024
by Reina Engle-Stone, K Ryan Wessells, Marjorie J. Haskell, Sika M. Kumordzie, Charles D. Arnold, Jennie N. Davis, Emily R. Becher, Ahmed D. Fuseini, Kania W. Nyaaba, Xiuping Tan, Katherine P. Adams, Georg Lietz, Stephen A. Vosti, Seth Adu-Afarwuah Introduction Micronutrient deficiencies are prevalent in West Africa, particularly among women of reproductive age (WRA) and young children. Bouillon is a promising food fortification vehicle due to its widespread consumption. This study aims to evaluate the impact of multiple micronutrient-fortified bouillon cubes, compared to control bouillon cubes (fortified with iodine only), on micronutrient status and hemoglobin concentrations among lactating and non-lactating WRA and young children in northern Ghana. Methods This randomized, controlled doubly-masked trial will be conducted in the Kumbungu and Tolon districts in the Northern Region of Ghana, where prior data indicate multiple micronutrient deficiencies are common. Participants will be: 1) non-pregnant non-lactating WRA (15–49 y), 2) children 2–5 y, and 3) non-pregnant lactating women 4–18 months postpartum. Eligible participants will be randomly assigned to receive household rations of one of two types of bouillon cubes: 1) a multiple micronutrient-fortified bouillon cube containing vitamin A, folic acid, vitamin B12, iron, zinc, and iodine, or 2) a control cube containing iodine only.Each participant’s household will receive a ration of bouillon cubes every 2 weeks, and households will be advised to prepare meals as usual, using the study-provided cubes. The trial duration will be 9 months for non-pregnant non-lactating WRA and children, and 3 months for lactating women. The primary outcomes will be changes in biomarkers of micronutrient status and hemoglobin among WRA and children and milk micronutrient concentrations among lactating women. Secondary outcomes will include change in prevalence of micronutrient deficiency and anemia; dietary intake of bouillon and micronutrients; inflammation, malaria, and morbidity symptoms; and child growth and development. Discussion Evidence from this study will inform discussions about bouillon fortification in Ghana and West Africa. Trial registration The trial was registered on ClinicalTrials.gov (NCT05178407) and the Pan-African Clinical Trial Registry (PACTR202206868437931). This manuscript reflects protocol version 4 (August 29, 2022).
Læs mere Tjek på PubMedTrond Mogens Aaløkken, Haseem Ashraf, Gunnar Einvik, Tøri Vigeland Lerum, Carin Meltzer, Jezabel Rivero Rodriguez, Ole Henning Skjønsberg, Knut Stavem
PLoS One Infectious Diseases, 6.05.2024
Tilføjet 6.05.2024
by Trond Mogens Aaløkken, Haseem Ashraf, Gunnar Einvik, Tøri Vigeland Lerum, Carin Meltzer, Jezabel Rivero Rodriguez, Ole Henning Skjønsberg, Knut Stavem Objectives To investigate changes in chest CT between 3 and 12 months and associations with disease severity in patients hospitalized for COVID-19 during the first wave in 2020. Materials and methods Longitudinal cohort study of patients hospitalized for COVID-19 in 2020. Chest CT was performed 3 and 12 months after admission. CT images were evaluated using a CT severity score (CSS) (0–12 scale) and recoded to an abbreviated version (0–3 scale). We analyzed determinants of the abbreviated CSS with multivariable mixed effects ordinal regression. Results 242 patients completed CT at 3 months, and 124 (mean age 62.3±13.3, 78 men) also at 12 months. Between 3 and 12 months (n = 124) CSS (0–12 scale) for ground-glass opacities (GGO) decreased from median 3 (25th–75th percentile: 0–12) at 3 months to 0.5 (0–12) at 12 months (p
Læs mere Tjek på PubMedZahra Mirsanei, Yahya Asemani, Milad Derakhshanjazari, Vahid Gharibi, Pirasteh Norouzi, Sepideh Mahdavi, Rosanna Cousins
PLoS One Infectious Diseases, 6.05.2024
Tilføjet 6.05.2024
by Zahra Mirsanei, Yahya Asemani, Milad Derakhshanjazari, Vahid Gharibi, Pirasteh Norouzi, Sepideh Mahdavi, Rosanna Cousins Heat exposure exceeding the ISO7243:1989 standard limit can contribute to health problems among employees in a variety of workplaces. Ignoring heat standard requirements in hot working conditions such as bakeries results in physiologic and health problems, as well as an elevated risk of later illnesses. In this analytical case-control study, the serum levels of four inflammatory factors (interleukin-1 beta, interleukin-6, tumor necrosis factor-α, and C-reactive protein) were assessed using an enzyme-linked immunosorbent assay. 105 male artisan bakers (in four job classifications in bakeries and staff) were compared based on demographic characteristics and inflammatory factors. The findings of the study showed correlations between serum interleukin-1β, interleukin-6, and C-reactive protein levels and thermal exposure in the occupational environment and employment type. Moreover, some differences in serum level of interleukin-1β and job type were observed. Heat overexposure affected the increase of interleukin-1β and C-reactive protein secretion. As a result of years of working in high-temperature conditions, inflammation can lead to subsequent diseases in workers. To protect their health from this occupational hazard, additional safeguards are needed. Our recommendations could also be applied to overly hot work environments that may cause heat stress in workers.
Læs mere Tjek på PubMedEmilia König, Shea Beasley, Paulina Heponiemi, Sanni Kivinen, Jaakko Räkköläinen, Seppo Salminen, Maria Carmen Collado, Tuomas Borman, Leo Lahti, Virpi Piirainen, Anna Valros, Mari Heinonen
PLoS One Infectious Diseases, 6.05.2024
Tilføjet 6.05.2024
by Emilia König, Shea Beasley, Paulina Heponiemi, Sanni Kivinen, Jaakko Räkköläinen, Seppo Salminen, Maria Carmen Collado, Tuomas Borman, Leo Lahti, Virpi Piirainen, Anna Valros, Mari Heinonen The early gut microbiota composition is fundamentally important for piglet health, affecting long-term microbiome development and immunity. In this study, the gut microbiota of postparturient dams was compared with that of their offspring in three Finnish pig farms at three growth phases. The differences in fecal microbiota of three study development groups (Good, Poorly, and PrematureDeath) were analyzed at birth (initial exposure phase), weaning (transitional phase), and before slaughter (stable phase). Dam Lactobacillaceae abundance was lower than in piglets at birth. Limosilactobacillus reuteri and Lactobacillus amylovorus were dominantly expressed in dams and their offspring. Altogether 17 piglets (68%) were identified with Lactobacillaceae at the initial exposure phase, divided unevenly among the development groups: 85% of Good, 37.5% of Poorly, and 75% of PrematureDeath pigs. The development group Good was identified with the highest microbial diversity, whereas the development group PrematureDeath had the lowest diversity. After weaning, the abundance and versatility of Lactobacillaceae in piglets diminished, shifting towards the microbiome of the dam. In conclusion, the fecal microbiota of pigs tends to develop towards a similar alpha and beta diversity despite development group and rearing environment.
Læs mere Tjek på PubMedKelong HanParul PatelScott McCallisterAlex R. RinehartYash GandhiWilliam SpreenRaphael J. LandovitzSinead Delany-MoretlweMark A. MarzinkeTodd McKeonPiotr BudnikJean van WykSusan L. Ford1GSK, Collegeville, Pennsylvania, USA2ViiV Healthcare, Durham, North Carolina, USA3ViiV Healthcare, Branford, Connecticut, USA4Center for Clinical AIDS Research and Education, David Geffen School of Medicine, University of California, Los Angeles, California, USA5Wits RHI, University of the Witwatersrand, Johannesburg, South Africa6Johns Hopkins University, Baltimore, Maryland, USA7ViiV Healthcare, Brentford, United Kingdom8GSK, Durham, North Carolina, USA, Ryan K. Shields
Antimicrobial Agents And Chemotherapy, 6.05.2024
Tilføjet 6.05.2024
Xin GuHaikong LuYilan YangLin ZhuMei ShiZhifang GuanLiyan NiRuirui PengWei ZhaoJuan WuTengfei QiPingyu Zhou1Institute of Sexually Transmitted Disease, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China, Laurent Poirel
Antimicrobial Agents And Chemotherapy, 6.05.2024
Tilføjet 6.05.2024
Koji TakemotoRyo NakayamaKoichi FujimotoYumiko SuzukiYukiko TakarabeMasako HonshoSachiko KitaharaYoshihiko NoguchiHidehito MatsuiTomoyasu HiroseYukihiro AsamiJun HidakaToshiaki SunazukaHideaki Hanaki1Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan2Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan3Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan, Laurent Poirel
Antimicrobial Agents And Chemotherapy, 6.05.2024
Tilføjet 6.05.2024
Jian HeYang YuWenhui LiuZhimin LiZhang QiShaoping WengChangjun GuoJianguo Hea State Key Laboratory for Biocontrol/Southern Laboratory of Ocean Science and Engineering (Guangdong, Zhuhai), Guangdong Provincial Observation and Research Station for Marine Ranching of the Lingdingyang Bay, School of Marine Sciences, Sun Yat-sen University, Guangzhou, PR Chinab Guangdong Province Key Laboratory of Aquatic Economic Animals, Sun Yat-sen University, Guangzhou, PR China
Virulence, 6.05.2024
Tilføjet 6.05.2024
Infectious Disease Modelling, 5.05.2024
Tilføjet 5.05.2024
Publication date: Available online 4 May 2024 Source: Infectious Disease Modelling Author(s): Anjana Pokharel, Khagendra Adhikari, Ramesh Gautam, Kedar Nath Uprety, Naveen K. Vaidya
Læs mere Tjek på PubMedInfectious Disease Modelling, 5.05.2024
Tilføjet 5.05.2024
Publication date: Available online 3 May 2024 Source: Infectious Disease Modelling Author(s): Brandon Robinson, Philippe Bisaillon, Jodi D. Edwards, Tetyana Kendzerska, Mohammad Khalil, Dominique Poirel, Abhijit Sarkar
Læs mere Tjek på PubMedTimothy M. UyekiCenters for Disease Control and Prevention, Atlanta, GA tmu0@cdc.gov, Scott Milton, and Cherissa Abdul HamidTexas Department of State Health Services, Lubbock, TX, Cynthia Reinoso Webb, and Steven M. PresleyTexas Tech University Bioterrorism Response Laboratory, Lubbock, TX, Varun Shetty, Susan N. Rollo, Diana L. Martinez, Saroj Rai, and Emilio R. GonzalesTexas Department of State Health Services, Austin, TX, Krista L. Kniss, Yunho Jang, Julia C. Frederick, Juan A. De La Cruz, Jimma Liddell, Han Di, Marie K. Kirby, John R. Barnes, and C. Todd DavisCenters for Disease Control and Prevention, Atlanta, GA
New England Journal of Medicine, 4.05.2024
Tilføjet 4.05.2024
Norma Rallón, Daniel Jiménez‐Carretero, Clara Restrepo, José M. Ligos, Jaime Valentín‐Quiroga, Ignacio Mahillo, Alfonso Cabello, Eduardo López‐Collazo, Fátima Sánchez‐Cabo, Miguel Górgolas, Vicente Estrada, José M. Benito, ECRIS integrated in the Spanish AIDS Research Network
Journal of Medical Virology, 4.05.2024
Tilføjet 4.05.2024
Xin‐Jing Zhao, Xiao‐Lin Liu, Yu‐Min Liang, Sheng Zhang, Ti Liu, Li‐Bo Li, Wen‐Guo Jiang, Jin‐Jin Chen, Qiang Xu, Chen‐Long Lv, Bao‐Gui Jiang, Zeng‐Qiang Kou, Guo‐Lin Wang, Li‐Qun Fang
Journal of Medical Virology, 4.05.2024
Tilføjet 4.05.2024
Norma Rallón, Daniel Jiménez‐Carretero, Clara Restrepo, José M. Ligos, Jaime Valentín‐Quiroga, Ignacio Mahillo, Alfonso Cabello, Eduardo López‐Collazo, Fátima Sánchez‐Cabo, Miguel Górgolas, Vicente Estrada, José M. Benito, ECRIS integrated in the Spanish AIDS Research Network
Journal of Medical Virology, 4.05.2024
Tilføjet 4.05.2024
Xin‐Jing Zhao, Xiao‐Lin Liu, Yu‐Min Liang, Sheng Zhang, Ti Liu, Li‐Bo Li, Wen‐Guo Jiang, Jin‐Jin Chen, Qiang Xu, Chen‐Long Lv, Bao‐Gui Jiang, Zeng‐Qiang Kou, Guo‐Lin Wang, Li‐Qun Fang
Journal of Medical Virology, 4.05.2024
Tilføjet 4.05.2024
Luciana P.S. Finamor, Maria Cássia Mendes-Correa, Mônica Rinkevicius, Guilherme Macedo, Ester Cerdeira Sabino, Lucy Santos Villas-Boas, Anderson Vicente de Paula, Raissa Heloisa de Araujo-Heliodoro, Antonio Charlys da Costa, Steven S. Witkin, Keila Lima Carneiro Santos, Camila Palmeira, Gabriel Andrade, Maurílio Lucena, Dalton Santoro, Luci Meire Pereira da Silva, Cristina Muccioli
International Journal of Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV) [1]. Ophthalmologic involvement, termed Monkeypox virus-related ophthalmic disease (MPXROD), encompasses a range of eye-related manifestations that can occur during Monkeypox virus (MPXV) infection. This includes lesions affecting both external structures, such as the periorbita and eyelids, as well as the ocular surface, including conditions like blepharoconjunctivitis, ulcerative keratitis, immune stromal and neurotrophic keratitis [2].
Læs mere Tjek på PubMedLucas C. de Sousa-Paula, Tom G. Schwan, Lucas Tirloni
Trends in Parasitology, 4.05.2024
Tilføjet 4.05.2024
Ornithodoros hermsi is a small, multihost soft tick that feeds rapidly on blood in all life stages, including larva, nymphal instars two to five (primarily three), and male and female. As adults, they can feed repeatedly and reproduce for many years. O. hermsi is nidicolous and primarily inhabits nest cavities and burrows of small rodents and birds, with chipmunks and tree squirrels serving as its primary hosts. When no hosts are available, they can fast for several years. O. hermsi is found in restricted habitats where their hosts live in coniferous pine and Douglas fir forests at elevations of 1500–10 000 feet in western North America.
Læs mere Tjek på PubMedTarcísio de Freitas Milagres, Carla Maia
Trends in Parasitology, 4.05.2024
Tilføjet 4.05.2024
Phlebotomus perniciosus, recognized as the most important phlebotomine sand fly vector in countries of the Western Mediterranean region, is responsible for transmitting the protozoan Leishmania infantum, the causative agent of zoonotic leishmaniasis. This species also serves as a vector for various phleboviruses, with the Toscana virus being the most clinically relevant, associated as one of the main causes of meningitis and encephalitis in this region. Detected in 22 countries, P. perniciosus has a broad distribution in countries located in the Western part of the Mediterranean basin.
Læs mere Tjek på PubMedMohd Farid Abdul Halim, Emily H. Hanson, Kyle C. Costa
Trends in Microbiology, 4.05.2024
Tilføjet 4.05.2024
Methanococcus maripaludis was first isolated in 1983 from the anoxic sediment of a salt marsh in South Carolina, USA. M. maripaludis grows by using H2 or formate to reduce CO2 to CH4 and is an autotroph that assimilates CO2 via the archaeal version of the Wood–Ljungdahl pathway. In some strains, supplementation of growth medium with acetate or propionate can increase biomass yield. This microorganism is strictly anaerobic, has a pleomorphic coccoid shape, and forms translucent, pale yellow, smooth colonies within 3 days on agar plates.
Læs mere Tjek på PubMedYuhang Wang, Matthew Theodore, Zhongliang Xing, Utkarsh Narsaria, Zihao Yu, Lanying Zeng, Junjie Zhang
Science Advances, 4.05.2024
Tilføjet 4.05.2024
Huwen Wang, Yuchen Wei, Chi Tim Hung, Guozhang Lin, Xiaoting Jiang, Conglu Li, Katherine Min Jia, Carrie Ho Kwan Yam, Tsz Yu Chow, Janice Ying-en Ho, Yawen Wang, Shi Zhao, Zihao Guo, Kehang Li, Aimin Yang, Chris Ka Pun Mok, David S C Hui, Eng Kiong Yeoh, Ka Chun Chong
Lancet Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
This study showed extended benefits of nirmatrelvir–ritonavir for reducing the risk of post-acute inpatient death as well as cardiovascular and respiratory complications among patients admitted to hospital with COVID-19. Further research is essential to uncover the underlying mechanisms responsible for these observed negative associations and to devise effective strategies for preventing the onset of post-acute sequelae.
Læs mere Tjek på PubMedClinical Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
Clinical Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
Evan Jarman, Jordan Burgess, Ayushi Sharma, Kate Hayashigatani, Amar Singh, Paige Fox
PLoS One Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
by Evan Jarman, Jordan Burgess, Ayushi Sharma, Kate Hayashigatani, Amar Singh, Paige Fox The complexity of chronic wounds creates difficulty in effective treatments, leading to prolonged care and significant morbidity. Additionally, these wounds are incredibly prone to bacterial biofilm development, further complicating treatment. The current standard treatment of colonized superficial wounds, debridement with intermittent systemic antibiotics, can lead to systemic side-effects and often fails to directly target the bacterial biofilm. Furthermore, standard of care dressings do not directly provide adequate antimicrobial properties. This study aims to assess the capacity of human-derived collagen hydrogel to provide sustained antibiotic release to disrupt bacterial biofilms and decrease bacterial load while maintaining host cell viability and scaffold integrity. Human collagen harvested from flexor tendons underwent processing to yield a gellable liquid, and subsequently was combined with varying concentrations of gentamicin (50–500 mg/L) or clindamycin (10–100 mg/L). The elution kinetics of antibiotics from the hydrogel were analyzed using liquid chromatography-mass spectrometry. The gel was used to topically treat Methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens in established Kirby-Bauer and Crystal Violet models to assess the efficacy of bacterial inhibition. 2D mammalian cell monolayers were topically treated, and cell death was quantified to assess cytotoxicity. Bacteria-enhanced in vitro scratch assays were treated with antibiotic-embedded hydrogel and imaged over time to assess cell death and mobility. Collagen hydrogel embedded with antibiotics (cHG+abx) demonstrated sustained antibiotic release for up to 48 hours with successful inhibition of both MRSA and C. perfringens biofilms, while remaining bioactive up to 72 hours. Administration of cHG+abx with antibiotic concentrations up to 100X minimum inhibitory concentration was found to be non-toxic and facilitated mammalian cell migration in an in vitro scratch model. Collagen hydrogel is a promising pharmaceutical delivery vehicle that allows for safe, precise bacterial targeting for effective bacterial inhibition in a pro-regenerative scaffold.
Læs mere Tjek på PubMedRaya Vinogradov, Eleanor Holden, Mehali Patel, Rowan Grigg, Linda Errington, Vera Araújo-Soares, Judith Rankin
PLoS One Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
by Raya Vinogradov, Eleanor Holden, Mehali Patel, Rowan Grigg, Linda Errington, Vera Araújo-Soares, Judith Rankin Introduction Women at increased risk of developing pre-eclampsia are advised to take a daily low-dose of aspirin from 12 weeks of pregnancy to reduce their risks. Despite the well-established prophylactic effect of aspirin, adherence to this therapy is low. This systematic review aimed to summarise evidence on the barriers and facilitators of adherence to low-dose aspirin to inform intervention development to support decision making and persistence with aspirin use for pre-eclampsia prevention. Materials and methods A systematic review and meta-synthesis of qualitative research was co-produced by representatives from charities, and public, clinical and academic members. Eight electronic databases (MEDLINE, PsycINFO, CINAHL, Web of Science, Scopus, EMBASE, Prospero, OpenGrey), archives of charities and professional organisations were searched (between October and November 2023 and re-run in August 2023) using predefined search terms. Studies containing qualitative components related to barriers and facilitators of adherence to low-dose aspirin during pregnancy were included. Quality assessment was performed using the Critical Appraisal Skills Programme checklist for qualitative research. A combination of the COM-B framework with phases of adherence process as defined by international taxonomy was used as the coding framework. Co-production activities were facilitated by use of ‘Zoom’ and ‘Linoit’. Results From a total of 3377 papers identified through our searches, five published studies and one dissertation met our inclusion criteria. Studies were published from 2019 to 2022 covering research conducted in the USA, Canada, UK, Netherlands and Australia. Barriers and facilitators to adherence were mapped to six categories of the COM-B for three phases of adherence: initiation, implementation, and discontinuation. The discontinuation phase of adherence was only mentioned by one author. Four key themes were identified relating to pregnancy: ‘Insufficient knowledge’, ‘Necessity concerns balance’, ‘Access to medicine’, ‘Social influences’, and ‘Lack of Habit’. Conclusions The COM-B framework allowed for detailed mapping of key factors shaping different phases of adherence in behavioural change terms and now provides a solid foundation for the development of a behavioural intervention. Although potential intervention elements could be suggested based on the results of this synthesis, additional co-production work is needed to define elements and plan for the delivery of the future intervention. Trial registration PROSPERO CRD42022359718. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022359718.
Læs mere Tjek på PubMedAyumi Hirao, Yasushi Hojo, Gen Murakami, Rina Ito, Miki Hashizume, Takayuki Murakoshi, Naonori Uozumi
PLoS One Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
by Ayumi Hirao, Yasushi Hojo, Gen Murakami, Rina Ito, Miki Hashizume, Takayuki Murakoshi, Naonori Uozumi Network oscillation in the anterior cingulate cortex (ACC) plays a key role in attention, novelty detection and anxiety; however, its involvement in cognitive impairment caused by acute systemic inflammation is unclear. To investigate the acute effects of systemic inflammation on ACC network oscillation and cognitive function, we analyzed cytokine level and cognitive performance as well as network oscillation in the mouse ACC Cg1 region, within 4 hours after lipopolysaccharide (LPS, 30 μg/kg) administration. While the interleukin-6 concentration in the serum was evidently higher in LPS-treated mice, the increases in the cerebral cortex interleukin-6 did not reach statistical significance. The power of kainic acid (KA)-induced network oscillation in the ACC Cg1 region slice preparation increased in LPS-treated mice. Notably, histamine, which was added in vitro, increased the oscillation power in the brain slices from LPS-untreated mice; for the LPS-treated mice, however, the effect of histamine was suppressive. In the open field test, frequency of entries into the center area showed a negative correlation with the power of network oscillation (0.3 μM of KA, theta band (3–8 Hz); 3.0 μM of KA, high-gamma band (50–80 Hz)). These results suggest that LPS-induced systemic inflammation results in increased network oscillation and a drastic change in histamine sensitivity in the ACC, accompanied by the robust production of systemic pro-inflammatory cytokines in the periphery, and that these alterations in the network oscillation and animal behavior as an acute phase reaction relate with each other. We suggest that our experimental setting has a distinct advantage in obtaining mechanistic insights into inflammatory cognitive impairment through comprehensive analyses of hormonal molecules and neuronal functions.
Læs mere Tjek på PubMedMor Keleynikov, Noga Cohen, Joy Benatov
PLoS One Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
by Mor Keleynikov, Noga Cohen, Joy Benatov Introduction Mothers faced an increased risk of adverse mental health outcomes during the COVID-19 pandemic compared to other populations. However, there is little data on the factors that placed mothers at increased risk of distress. Aims The present study explored a range of individual, familial, and environmental factors associated with psychological distress in mothers during the COVID-19 pandemic. Method This repeated cross-sectional study was composed of a convenience sample of mothers who completed an online survey that included a demographic questionnaire, an emotion regulation questionnaire, and the Depression, Anxiety, and Stress scale. The survey was administered during the second and third lockdowns in Israel in 2020–2021. Results The study included 575 mothers (M age = 39). The findings of a hierarchical regression indicated that individual-level factors, composed of age and emotion regulation tendencies predicted psychological distress. The family-level factors of household income and number of children in the family also predicted distress. In terms of environmental-level factors, COVID-19-related media consumption and school status (open or closed) were also significant predictors of psychological distress. Importantly, the results showed that the most important predictors of psychological distress in mothers during the COVID-19 outbreak were school closures, household income, and the use of adaptive and maladaptive emotion regulation strategies. Conclusions The findings highlight the intersection of individual, familial, and environmental factors in mothers’ mental health during crises.
Læs mere Tjek på PubMedSwaantje Casjens, Dirk Taeger, Thomas Brüning, Thomas Behrens
PLoS One Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
by Swaantje Casjens, Dirk Taeger, Thomas Brüning, Thomas Behrens Objectives The COVID-19 pandemic changed the future of work sustainably and led to a general increase in mental stress. A study conducted during the second and third pandemic wave with a retrospective survey of the first wave among 1,545 non-healthcare workers confirmed an increase in anxiety and depression symptoms and showed a correlation with the occupational SARS-CoV-2 infection risk. This online follow-up survey aims to examine changes in mental distress as the pandemic progressed in Germany and to identify factors influencing potential changes. Methods Longitudinal data from 260 subjects were available for this analysis. Mental distress related to anxiety and depression symptoms, assessed by the Patient Health Questionnaire-4 (PHQ-4), and occupational risk factors were solicited at the end of 2022 and retrospectively at the fifth wave. Categorized PHQ-4 scores were modelled with mixed ordinal regression models and presented with odds ratios (OR) and 95% confidence intervals (95% CI). Results A previous diagnosis of a depressive or anxiety disorder was a strong risk factor for severe symptoms (OR 3.49, 95% CI 1.71–7.11). The impact of occupational SARS-CoV-2 infection risk on mental distress was increased, albeit failing to reach the formal level of statistical significance (high risk OR 1.83, 95% CI 0.59–5.63; probable risk OR 1.72, 95% CI 0.93–3.15). Mental distress was more pronounced in those with a previous diagnosis of anxiety and depression. Confirmed occupational risk factors were protective measures against occupational SARS-CoV-2 infection perceived as inadequate, chronic work-related stress, overcommitment, reduced interactions with fellow-workers, and work-privacy conflicts. Conclusions The pandemic had a negative impact on anxiety and depression symptoms among the studied non-healthcare workers, particularly early in the pandemic, although this effect does not appear to be permanent. There are modifiable risk factors that can protect workers’ mental health, including strengthening social interactions among employees and reducing work-privacy conflicts.
Læs mere Tjek på PubMedRaphael Adu-Gyamfi, Juliana Enos, Kwame Yeboah, Veronika Shabanova, Nicola Hawley, Deda Alangea Ogum, Adwoa Agyei Nkansah, Elijah Paintsil, Kwasi Torpey
PLoS One Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
by Raphael Adu-Gyamfi, Juliana Enos, Kwame Yeboah, Veronika Shabanova, Nicola Hawley, Deda Alangea Ogum, Adwoa Agyei Nkansah, Elijah Paintsil, Kwasi Torpey Background Although AIDS-related deaths have reduced with increased access to antiretroviral care, cardiovascular disease-related morbidities among persons living with HIV are rising. Contributing to this is the higher incidence of Hypertension among Persons Living with HIV. The duration of exposure to the virus and antiretroviral drugs plays a vital role in the pathogenesis, putting perinatally infected children and adolescents at higher risk than behaviorally-infected ones, supporting the calls for increased surveillance of Hypertension among them. Despite the availability of guidelines to support this surveillance, the blood pressure (BP) of adolescents living with HIV (ADLHIV) is not checked during clinical visits. This study aims to assess the effect of a theory-based intervention on healthcare workers’ adherence to the guidelines for hypertension screening among adolescents. Methods A multi-facility cluster-randomized study will be conducted. The clusters will be 20 antiretroviral therapy sites in the Greater Accra Region of Ghana with the highest adolescent caseload. Data will be extracted from the folders of adolescents (10–17 years) who received care in these facilities six months before the study. The ART staff of intervention facilities will receive a multicomponent theory of planned behaviour-based intervention. This will include orientation on hypertension risk among ADLHIV, provision of job aids and pediatric sphygmomanometers. Six months after the intervention, the outcome measure will be the change from baseline in the proportion of ADLHIV whose BP was checked during clinical visits. The calculated sample size is 400 folders. Implications of findings This study will generate evidence on the effectiveness of a multicomponent theory-based intervention for improving the implementation of clinical practice guidelines. Trial registration PACTR202205641023383.
Læs mere Tjek på PubMedYuxin Zou, Manyi Pan, Tianyu Zhou, Lifeng Yan, Yuntian Chen, Junjie Yun, Zhihua Wang, Huaqi Guo, Kai Zhang, Weining Xiong
PLoS One Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
by Yuxin Zou, Manyi Pan, Tianyu Zhou, Lifeng Yan, Yuntian Chen, Junjie Yun, Zhihua Wang, Huaqi Guo, Kai Zhang, Weining Xiong Celiac disease exhibits a higher prevalence among patients with coronavirus disease 2019. However, the potential influence of COVID-19 on celiac disease remains uncertain. Considering the significant association between gut microbiota alterations, COVID-19 and celiac disease, the two-step Mendelian randomization method was employed to investigate the genetic causality between COVID-19 and celiac disease, with gut microbiota as the potential mediators. We employed the genome-wide association study to select genetic instrumental variables associated with the exposure. Subsequently, these variables were utilized to evaluate the impact of COVID-19 on the risk of celiac disease and its potential influence on gut microbiota. Employing a two-step Mendelian randomization approach enabled the examination of potential causal relationships, encompassing: 1) the effects of COVID-19 infection, hospitalized COVID-19 and critical COVID-19 on the risk of celiac disease; 2) the influence of gut microbiota on celiac disease; and 3) the mediating impact of the gut microbiota between COVID-19 and the risk of celiac disease. Our findings revealed a significant association between critical COVID-19 and an elevated risk of celiac disease (inverse variance weighted [IVW]: P = 0.035). Furthermore, we observed an inverse correlation between critical COVID-19 and the abundance of Victivallaceae (IVW: P = 0.045). Notably, an increased Victivallaceae abundance exhibits a protective effect against the risk of celiac disease (IVW: P = 0.016). In conclusion, our analysis provides genetic evidence supporting the causal connection between critical COVID-19 and lower Victivallaceae abundance, thereby increasing the risk of celiac disease.
Læs mere Tjek på PubMedTsuyoshi MikiMasahiro ItoNobuhiko OkadaTakeshi Haneda1Department of Microbiology, School of Pharmacy, Kitasato University, Tokyo, Japan, Manuela Raffatellu
Infection and Immunity, 4.05.2024
Tilføjet 4.05.2024
Christina ThompsonConnor WaldronSierra GeorgeZhiming Ouyang1Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA, Guy H. Palmer
Infection and Immunity, 4.05.2024
Tilføjet 4.05.2024
Anna MiyaharaAya UmekiKo SatoToshiki NomuraHideki YamamotoTomomitsu MiyasakaDaiki TannoIkumi MatsumotoTong ZongTakafumi KagesawaAkiho OniyamaKotone KawamuraXiaoliang YuanRin YokoyamaYuki KitaiEmi KannoHiromasa TannoHiromitsu HaraSho YamasakiShinobu SaijoYoichiro IwakuraKeiko IshiiKazuyoshi Kawakami1Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan2Center for Medical Education, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan3Department of Translational Science for Nursing, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan4Department of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan5Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan6Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan7Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan8Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan, Mairi C. Noverr
Infection and Immunity, 4.05.2024
Tilføjet 4.05.2024
Rajotiya, S., Mishra, S., Singh, A. K., Debnath, S., Raj, P., Singh, P., Bareth, H., Nakash, P., Sharma, A., Singh, M., Nathiya, D., Joshi, N., Tomar, B. S.
BMJ Open, 3.05.2024
Tilføjet 3.05.2024
ObjectiveThis study aimed to investigate the burden of the COVID-19 pandemic on tuberculosis (TB) trends, patient demographics, disease types and hospitalisation duration within the Respiratory Medicine Department over three distinct phases: pre-COVID-19, COVID-19 and post-COVID-19. DesignRetrospective analysis using electronic medical records of patients with TB admitted between June 2018 and June 2023 was done to explore the impact of COVID-19 on patients with TB. The study employed a meticulous segmentation into pre-COVID-19, COVID-19 and post-COVID-19 eras. SettingNational Institute of Medical Science Hospital in Jaipur, Rajasthan, India. Primary and secondary outcome measuresPrimary outcome includes patients admitted to the Respiratory Medicine Department of the hospital and secondary outcome involves the duration of hospital stay. ResultsThe study encompassed 1845 subjects across the three eras, revealing a reduction in TB incidence during the post-COVID-19 era compared with the pre-COVID-19 period (p
Læs mere Tjek på PubMedLittle, R. B., Carter, S. J., Motl, R. W., Hunter, G., Cook, A., Liu, N., Krontiras, H., Lefkowitz, E. J., Turan, B., Schleicher, E., Rogers, L. Q.
BMJ Open, 3.05.2024
Tilføjet 3.05.2024
IntroductionBreast cancer survivors have an increased risk for chronic fatigue and altered gut microbiota composition, both with negative health and quality of life affects. Exercise modestly improves fatigue and is linked to gut microbial diversity and production of beneficial metabolites. Studies suggest that gut microbiota composition is a potential mechanism underlying fatigue response to exercise. Randomised controlled trials testing the effects of exercise on the gut microbiome are limited and there is a scarcity of findings specific to breast cancer survivors. The objective of this study is to determine if fitness-related modifications to gut microbiota occur and, if so, mediate the effects of aerobic exercise on fatigue response. Methods and analysisThe research is a randomised controlled trial among breast cancer survivors aged 18–74 with fatigue. The primary aim is to determine the effects of aerobic exercise training compared with an attention control on gut microbiota composition. The secondary study aims are to test if exercise training (1) affects the gut microbiota composition directly and/or indirectly through inflammation (serum cytokines), autonomic nervous system (heart rate variability) or hypothalamic-pituitary-adrenal axis mediators (hair cortisol assays), and (2) effects on fatigue are direct and/or indirect through changes in the gut microbiota composition. All participants receive a standardised controlled diet. Assessments occur at baseline, 5 weeks, 10 weeks and 15 weeks (5 weeks post intervention completion). Faecal samples collect the gut microbiome and 16S gene sequencing will identify the microbiome. Fatigue is measured by a 13-item multidimensional fatigue scale. Ethics and disseminationThe University of Alabama at Birmingham Institutional Review Board (IRB) approved this study on 15 May 2019, UAB IRB#30000320. A Data and Safety Monitoring Board convenes annually or more often if indicated. Findings will be disseminated in peer-reviewed journals and conference presentations. Trial registration numberClinicalTrials.gov, NCT04088708.
Læs mere Tjek på PubMedArnaout, A. Y., Nerabani, Y., Sawas, M. N., Alhejazi, T. J., Farho, M. A., Arnaout, K., Alshaker, H., Shebli, B., Helou, M., Mobaied, B. B., Mouti, M. B., Kady, F., Aljarad, Z., Aleppo University Hospital Team, shalabi, Dasouki, Breij, Shheibar, Alabdullah, Wais, Atli, Breis, Jamal, Abduljalil, Mashhadi, Shyah, Zitani, Breim, Maarawi, Jafa, Saleh, Bathish, mhawsh, Arnaout, Khalili, Markaby, Damour, Kanaa, Kitan, Jaber, Tfnkjy, Amaraya, Zeno, Nayef, Mobaid, Alrawi, Jadid, Farho, Kreid, Sawas, Martini, Alkhalifa, Al-kurdi, Mahmoud, Barakat, Keblawy, Fjleh, Arab, Hamdan, Alkhallouf, Sattout, Ibrahim, aouir, Modabbes, Arian, Haykal, Faour, Al-wannous, Bourghol, Alkurayem, Masoud, helou, Rihawi, radwan, Sagheer, Adna, Najeb, Jawesh, Hritani, Dordi, Alali, Toffaha, Alsayed-Ahmad, Badawi, Ghannam, Alhasan, Al-Nabbash, Kouli, Bayaa, Alhaji, Tabbaa, Alakkash, Alothman, Abazid, Taleb, Rokia, Aljarad, Tarabelsi, Hamza, Karaze, Ibrahim, Hamsho, Ramadan, Alzalek, Masri, Mano, Kurdi, Assi, Abazid, Bathish
BMJ Open, 3.05.2024
Tilføjet 3.05.2024
ObjectivesThe aim of this study is a descriptive presentation of cases of acute watery diarrhoea (AWD) that were presented to Aleppo University Hospital (AUH) during the recent cholera outbreak in Syria. DesignProspective, observational, cohort study. Setting and participantsA total of 1061 patients with AWD were admitted to AUH during the timeframe of 20 September 2022 to 20 October 2022. The data collection was done through a structured questionnaire. This includes comprehensive clinical observation, laboratory analyses, therapeutic interventions and holistic case evaluations. ResultsThe analysis has revealed notable insights: a predominant proportion of patients (58.6%) were residents from urban areas and 40.3% were residents from rural areas. Intriguingly, a diverse range of potential infection sources emerged from patient data within our hospital, including uncontrolled well water, vegetables and faecal-oral transmission through contaminated street/fast food. At discharge, most patients were in good health (79.7%), followed by moderate health (17.6%) and poor health (2.3%), with a minimal percentage dying before discharge (0.4%). The most common complications reported at admission and during hospitalisation included electrolyte imbalance (28.2%), followed by severe dehydration (16.3%). In the follow-up period, the majority of patients exhibited good health (81.0%). Older patients (>60 years) had poorer outcomes, with 8.4% having poor health and 4.2% death rate. ConclusionsThe study found results consistent with previous AWD outbreaks in developing countries like Yemen, Nigeria and Lebanon. Preventative measures like improving water sanitation and hygiene practices are essential to prevent future outbreaks and ease the strain on healthcare systems. Therefore, future studies must investigate the risk factors that increase the spread and the severity of the disease and investigate the best management method.
Læs mere Tjek på PubMedBMJ Open, 3.05.2024
Tilføjet 3.05.2024
Sweetnam C, Goulding L, Davis RE, et al. Development and psychometric evaluation of the Implementation Science Research Project Appraisal Criteria (ImpResPAC) tool: a study protocol. BMJ Open 2022;12:e061209. doi: 10.1136/bmjopen-2022-061209. Above mentioned article is revised since it was published as Funding statement is now updated as given below: This research was supported by the National Institute for Health Research (NIHR) Applied Research Collaboration (ARC) South London at King’s College Hospital NHS Foundation Trust; and by King’s Improvement Science, which offers co-funding to the NIHR ARC South London and is funded by King’s Health Partners (Guy’s and St Thomas’ NHS Foundation Trust, King’s College Hospital NHS Foundation Trust, King’s College London and South London and Maudsley NHS Foundation Trust), and Guy’s and St Thomas’ Charity (grant number: NIHR200152). NS’ research is further supported by the ASPIRES research programme (Antibiotic use across Surgical Pathways - Investigating, Redesigning and Evaluating Systems), funded...
Læs mere Tjek på PubMedSergio MagallanesFrancisco LlorenteMaría José Ruiz-LópezJosué Martínez-de la PuenteMartina FerragutiRafael Gutiérrez-LópezRamón SoriguerPilar Aguilera-SepúlvedaRaúl Fernández-DelgadoMiguel Ángel Jímenez-ClaveroJordi Figuerolaa Department of Conservation Biology and Global Change, Estación Biológica de Doñana (EBD), CSIC, Seville, Spainb CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spainc Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC, Valdeolmos, Spaind Department of Parasitology, University of Granada, Granada, Spaine Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spainf CIBER of Infectious Diseases (CIBERINFEC), Madrid, Spain
Emerg Microbes Infect, 3.05.2024
Tilføjet 3.05.2024
Shirin TaheriMikel Alexander GonzálezMaría José Ruiz-LópezSergio MagallanesSarah Delacour-EstrellaJavier LucientesRubén Bueno-MaríJosué Martínez-de la PuenteDaniel Bravo-BarrigaEva FronteraAlejandro PolinaYasmina Martinez-BarcielaJosé Manuel PereiraJosefina GarridoCarles ArandaAlfonso MarzalIgnacio Ruiz-ArrondoJosé Antonio OteoMartina FerragutiRafael Gutíerrez-LópezRosa EstradaMiguel Ángel MirandaCarlos BarcelóRodrigo MorchónTomas MontalvoLaura GangosoFátima GoiriAna L. García-PérezSantiago RuizBeatriz Fernandez-MartinezDiana Gómez-BarrosoJordi Figuerolaa Departamento de Biología de la Conservación y Cambio Global, Estación Biológica de Doñana (EBD), CSIC, Sevilla, Spainb CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spainc The Agrifood Institute of Aragón (IA2), Faculty of Veterinary Medicine, University of Zaragoza, Zaragoza, Spaind Center of Excellence in Vector Control, Rentokil Initial, València, Spaine Grupo de Investigación Parásitos y Salud, Universitat de València, València, Spainf Departamento de Parasitología, Universidad de Granada, Granada, Spaing Departamento de Salud Animal, Grupo de Investigación en Salud Animal y Zoonosis (GISAZ), Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spainh Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura (UEx), Cáceres, Spaini Departamento de Ecoloxía e Bioloxía Animal, Universidade de Vigo, Pontevedra, Spainj Departamento de Zooloxía, Xenética e Antropoloxía Física, Universidade de Santiago de Compostela, A Coruña, Spaink Servei de Control de Mosquits del Baix Llobregat, Sant Feliu del Llobregat, Barcelona, Spainl IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus Universitat Autònoma de Barcelona, Bellaterra, Spainm Facultad de Biología, Universidad de Extremadura, Badajoz, Spainn Grupo de Investigaciones en Fauna Silvestre, Universidad Nacional de San Martín, Tarapoto, Perúo Centre of Rickettsiosis and Arthropod-Borne Diseases, Hospital Universitario San Pedro-CIBIR, La Rioja, Logroño, Spainp Centro Nacional de Microbiología (CNM-ISCIII), Madrid, Spainq CIBER de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spainr Universitat de les Illes Balears (UIB), Zoología Aplicada y de la Conservación, Palma, Spains Zoonotic Diseases and One Health Group, Faculty of Pharmacy, Universidad de Salamanca, Salamanca, Spaint Agencia de Salut Publica de Barcelona, Barcelona, Spainu Universidad Complutense de Madrid, Madrid, Spainv NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Derio, Spainw Servicio de Control de Mosquitos de la Diputación de Huelva, Huelva, Spainx Centro Nacional de Epidemiologia (CNE-ISCIII), Madrid, Spain
Emerg Microbes Infect, 3.05.2024
Tilføjet 3.05.2024
Sijie YangYuanling YuFanchong JianAyijiang YisimayiWeiliang SongJingyi LiuPeng WangYanli XuJing WangXiao NiuLingling YuYao WangFei ShaoRonghua JinYouchun WangYunlong Caoa Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, People’s Republic of Chinab Changping Laboratory, Beijing, People’s Republic of Chinac Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, People’s Republic of Chinad College of Chemistry and Molecular Engineering Peking University, Beijing, People’s Republic of Chinae School of Life Sciences, Peking University, Beijing, People’s Republic of Chinaf College of Future Technology Peking University, Beijing, People’s Republic of Chinag Beijing Ditan Hospital Capital Medical University, Beijing, People’s Republic of Chinah Institute of Medical Biology Chinese Academy of Medical Science & Peking Union Medical College, Kunming, People’s Republic of China
Emerg Microbes Infect, 3.05.2024
Tilføjet 3.05.2024