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Infection, 3.05.2024
Tilføjet 3.05.2024
Abstract Purpose To analyse recent epidemiological trends of bloodstream infections (BSI) caused by Enterococcus spp. In adult patients admitted to tertiary care centres in Germany. Methods Epidemiological data from the multicentre R-NET study was analysed. Patients presenting with E. faecium or E. faecalis in blood cultures in six German tertiary care university hospitals between October 2016 and June 2020 were prospectively evaluated. In vancomycin-resistant enterococci (VRE), the presence of vanA/vanB was confirmed via molecular methods. Results In the 4-year study period, 3001 patients with BSI due to Enterococcus spp. were identified. E. faecium was detected in 1830 patients (61%) and E. faecalis in 1229 patients (41%). Most BSI occurred in (sub-) specialties of internal medicine. The pooled incidence density of enterococcal BSI increased significantly (4.0–4.5 cases per 10,000 patient days), which was primarily driven by VRE BSI (0.5 to 1.0 cases per 10,000 patient days). In 2020, the proportion of VRE BSI was > 12% in all study sites (range, 12.8–32.2%). Molecular detection of resistance in 363 VRE isolates showed a predominance of the vanB gene (77.1%). Conclusion This large multicentre study highlights an increase of BSI due to E. faecium, which was primarily driven by VRE. The high rates of hospital- and ICU-acquired VRE BSI point towards an important role of prior antibiotic exposure and invasive procedures as risk factors. Due to limited treatment options and high mortality rates of VRE BSI, the increasing incidence of VRE BSI is of major concern.
Læs mere Tjek på PubMedInfection, 1.05.2024
Tilføjet 1.05.2024
Abstract Purpose To analyse recent epidemiological trends of bloodstream infections (BSI) caused by Enterococcus spp. In adult patients admitted to tertiary care centres in Germany. Methods Epidemiological data from the multicentre R-NET study was analysed. Patients presenting with E. faecium or E. faecalis in blood cultures in six German tertiary care university hospitals between October 2016 and June 2020 were prospectively evaluated. In vancomycin-resistant enterococci (VRE), the presence of vanA/vanB was confirmed via molecular methods. Results In the 4-year study period, 3001 patients with BSI due to Enterococcus spp. were identified. E. faecium was detected in 1830 patients (61%) and E. faecalis in 1229 patients (41%). Most BSI occurred in (sub-) specialties of internal medicine. The pooled incidence density of enterococcal BSI increased significantly (4.0–4.5 cases per 10,000 patient days), which was primarily driven by VRE BSI (0.5 to 1.0 cases per 10,000 patient days). In 2020, the proportion of VRE BSI was > 12% in all study sites (range, 12.8–32.2%). Molecular detection of resistance in 363 VRE isolates showed a predominance of the vanB gene (77.1%). Conclusion This large multicentre study highlights an increase of BSI due to E. faecium, which was primarily driven by VRE. The high rates of hospital- and ICU-acquired VRE BSI point towards an important role of prior antibiotic exposure and invasive procedures as risk factors. Due to limited treatment options and high mortality rates of VRE BSI, the increasing incidence of VRE BSI is of major concern.
Læs mere Tjek på PubMedAnca Rath, Bärbel Kieninger, Nilufarbayim Mirzaliyeva, Stephan Schmid, Patricia Mester, Wulf Schneider-Brachert
Clinical Microbiology and Infection, 24.04.2024
Tilføjet 24.04.2024
Surveillance of multidrug-resistant bacteria like vancomycin-resistant enterococci (VRE) and prompt outbreak recognition are vital for infection prevention and control (IPC). Yet, data collection is laborious, and analysis prone to errors due to limited resolution of common diagnostic tools. Precision in defining \'the same pathogen\' is, however, critical for nosocomial transmission analysis.
Læs mere Tjek på PubMedJoachim MariënMickaël SageUmaru BanguraAlicia LaméMichel KoropoguiToni RiegerBarré SoropoguiMoussa DounoN’Faly MagassoubaElisabeth Fichet-Calveta Evolutionary Ecology group, Department of Biology University of Antwerp, Antwerp, Belgiumb Virus Ecology unit, Department of Biomedical sciences, Institute of Tropical Medicine, Antwerp, Belgiumc Faune INNOV’ R&D – Wildlife INNOVATION, Besançon, Franced Implementation Research, Zoonoses Control group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germanye Projet des fièvres Hémorragiques en Guinée, Laboratoire de Virologie, Conakry, Guineaf Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Emerg Microbes Infect, 21.04.2024
Tilføjet 21.04.2024
Mohamed Ali MarouiGrace Akinyi OdongoLucia MundoFrancesca ManaraFabrice MureFloriane FusilAntonin JayTarik GheitThanos M. MichailidisDomenico FerraraLorenzo LeonciniPaul MurrayEvelyne ManetThéophile OhlmannMarthe De BoevreSarah De SaegerFrançois-Loïc CossetStefano LazziRosita AccardiZdenko HercegHenri GruffatRita KhoueiryaCentre International de Recherche en Infectiologie, University Claude Bernard Lyon I, INSERM U1111, CNRS UMR5308, Ecole Normale Supérieure, Lyon 69366 Cedex 07, FrancebEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, World Health Organization, Lyon 69366 Cedex 07, FrancecLimerick Digital Cancer Research Centre, Health Research Institute, Bernal Institute and School of Medicine, University of Limerick, Limerick V94 T9PX, IrelanddDepartment of Medical Biotechnology, Section of Pathology, University of Siena, Siena 53100, ItalyeCentre of Excellence in Mycotoxicology and Public Health, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent 9000, BelgiumfDepartment of Biotechnology and Food Technology, Faculty of Science, University of Johannesburg, Gauteng 2028, South Africa
Proceedings of the National Academy of Sciences, 17.04.2024
Tilføjet 17.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 16, April 2024.
Læs mere Tjek på PubMedJulien Favresse, Constant Gillot, Julien Cabo, Clara David, Jean-Michel Dogné, Jonathan Douxfils
International Journal of Infectious Diseases, 5.04.2024
Tilføjet 5.04.2024
An increase evasion of the SARS-CoV-2 virus towards vaccination strategies and natural immunity has been rapidly described notably due to mutations in the spike receptor binding domain (RBD) and the N-terminal domain (NTD)C.
Læs mere Tjek på PubMedMohamed Ali MarouiGrace Akinyi OdongoLucia MundoFrancesca ManaraFabrice MureFloriane FusilAntonin JayTarik GheitThanos M. MichailidisDomenico FerraraLorenzo LeonciniPaul MurrayEvelyne ManetThéophile OhlmannMarthe De BoevreSarah De SaegerFrançois-Loïc CossetStefano LazziRosita AccardiZdenko HercegHenri GruffatRita KhoueiryaCentre International de Recherche en Infectiologie, University Claude Bernard Lyon I, INSERM U1111, CNRS UMR5308, Ecole Normale Supérieure, Lyon 69366 Cedex 07, FrancebEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, World Health Organization, Lyon 69366 Cedex 07, FrancecLimerick Digital Cancer Research Centre, Health Research Institute, Bernal Institute and School of Medicine, University of Limerick, Limerick V94 T9PX, IrelanddDepartment of Medical Biotechnology, Section of Pathology, University of Siena, Siena 53100, ItalyeCentre of Excellence in Mycotoxicology and Public Health, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent 9000, BelgiumfDepartment of Biotechnology and Food Technology, Faculty of Science, University of Johannesburg, Gauteng 2028, South Africa
Proceedings of the National Academy of Sciences: Immunology and Inflammation, 5.04.2024
Tilføjet 5.04.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 16, April 2024.
Læs mere Tjek på PubMedJournal of Infectious Diseases, 28.03.2024
Tilføjet 28.03.2024
Abstract Background Admission and discharge screening of patients for asymptomatic gut colonization with multidrug-resistant organisms (MDROs) is a traditional approach to active surveillance, but its sensitivity for detecting colonization is uncertain.Methods Daily rectal or fecal swab samples and clinical data were collected over 12 months from patients in one 25-bed intensive care unit (ICU) in Chicago, IL USA and tested for the following multidrug-resistant organisms (MDROs): vancomycin-resistant enterococci (VRE); third-generation cephalosporin-resistant Enterobacterales, including extended-spectrum β-lactamase-producing Enterobacterales (ESBL); and carbapenem-resistant Enterobacterales (CRE). MDRO detection by (1) admission/discharge surveillance cultures or (2) clinical cultures were compared to daily surveillance cultures. Samples underwent 16S rRNA gene sequencing to measure the relative abundance of operational taxonomic units (OTUs) corresponding to each MDRO.Results Compared with daily surveillance cultures, admission/discharge cultures detected 91% of prevalent MDRO colonization and 63% of incident MDRO colonization among medical ICU patients. Only a minority (7%) of MDRO carriers were identified by clinical cultures. Higher relative abundance of MDRO-associated OTUs and specific antibiotic exposures were independently associated with higher probability of MDRO detection by culture.Conclusion Admission and discharge surveillance cultures underestimated MDRO acquisitions in an ICU. These limitations should be considered when designing sampling strategies for epidemiologic studies that use culture-based surveillance.
Læs mere Tjek på PubMedStefania D’AriaCéline MaquetShuang LiSuveera DhupAnouk LepezArnaud KohlerVincent F. Van HéeRajesh K. DadhichMarine FrenièreFabienne AndrisIvan NemazanyyPierre SonveauxBénédicte MachielsLaurent GilletMichel Y. BraunaInstitute for Medical Immunology, Faculty of Medicine, Université libre de Bruxelles, Gosselies 6041, BelgiumbImmunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - Fundamental and Applied Research for Animals & Health Research Unit, University of Liège, Liège 4000, BelgiumcPole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels 1200, BelgiumdImmunobiology Laboratory, Faculty of Sciences, Université libre de Bruxelles, Gosselies 6041, BelgiumePlateforme d’étude du métabolisme, Institut Necker, Inserm US 24 - CNRS UMS 3633, Faculté de Médecine Paris Descartes, Paris 75015, FrancefWEL Research Institute, Welbio Department, Wavre 1300, Belgium
Proceedings of the National Academy of Sciences, 28.03.2024
Tilføjet 28.03.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 13, March 2024.
Læs mere Tjek på PubMedAlbert Tell i Puig, Dominique Soldati-Favre
Trends in Parasitology, 26.03.2024
Tilføjet 26.03.2024
Microtubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heavily relies on the tubulin structures present in the apical complex. Recent advances in high-resolution imaging, coupled with reverse genetics, have offered deeper insights into the composition, functionality, and dynamics of these tubulin-based structures. The apicomplexan tubulins differ from those of their mammalian hosts, endowing them with unique attributes and susceptibility to specific classes of inhibitory compounds.
Læs mere Tjek på PubMedStefania D’AriaCéline MaquetShuang LiSuveera DhupAnouk LepezArnaud KohlerVincent F. Van HéeRajesh K. DadhichMarine FrenièreFabienne AndrisIvan NemazanyyPierre SonveauxBénédicte MachielsLaurent GilletMichel Y. BraunaInstitute for Medical Immunology, Faculty of Medicine, Université libre de Bruxelles, Gosselies 6041, BelgiumbImmunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - Fundamental and Applied Research for Animals & Health Research Unit, University of Liège, Liège 4000, BelgiumcPole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels 1200, BelgiumdImmunobiology Laboratory, Faculty of Sciences, Université libre de Bruxelles, Gosselies 6041, BelgiumePlateforme d’étude du métabolisme, Institut Necker, Inserm US 24 - CNRS UMS 3633, Faculté de Médecine Paris Descartes, Paris 75015, FrancefWEL Research Institute, Welbio Department, Wavre 1300, Belgium
Proceedings of the National Academy of Sciences: Immunology and Inflammation, 19.03.2024
Tilføjet 19.03.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 13, March 2024.
Læs mere Tjek på PubMedPeter BagerJonas KählerMikael AnderssonBarbara Juliane HolzknechtSanne Grønvall Kjær HansenKristian SchønningKaren Leth NielsenKristoffer KochMette PinholtMarianne VoldstedlundAnders Rhod LarsenBrian KristensenKåre MølbakUte Wolff SönksenSissel SkovgaardRobert SkovAnette M. Hammeruma Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmarkb Department of Dataintegration and -Analysis, Statens Serum Institut, Copenhagen, Denmarkc Department of Clinical Microbiology, Copenhagen University Hospital – Herlev and Gentofte, Herlev, Denmarkd Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmarke Department of Clinical Microbiology, Odense University Hospital, Odense, Denmarkf Department of Clinical Microbiology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmarkg Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmarkh Department of Clinical Microbiology, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmarki Division of Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmarkj National Reference Laboratory for Antimicrobial Resistance, Statens Serum Institut, Copenhagen, Denmarkk Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmarkl Department of Veterinary and Animal Sciences, Faculty of Health, University of Copenhagen, Denmarkm Department of Bacteria, Parasites, and Fungi, Statens Serum Institut, Copenhagen, Denmark
Emerg Microbes Infect, 12.03.2024
Tilføjet 12.03.2024
Umaru BanguraChristopher DavisJoyce LaminJames BanguraBarré SoropoguiAndrew J. DavisonJenna NicholsMatej VucakMickael DawsonRashid AnsumanaDianah SondufuDániel CadarToni RiegerEmma ThomsonFoday SahrN’Faly MagassoubaBruno GhersiBrian H. BirdElisabeth Fichet-Calveta Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germanyb MRC-University of Glasgow Centre for Virus Research, Glasgow, UKc Mercy Hospital Research Laboratory, Bo, Sierra Leoned University of Makeni and University of California, Davis One Health Program, Makeni, Sierra Leonee Laboratoire des Fièvres Hémorragiques en Guinée, Conakry, Guineaf College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leoneg One Health Institute, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA
Emerg Microbes Infect, 7.03.2024
Tilføjet 7.03.2024