Søgning på udtrykket 'clostri' giver 48 resultater
Dokumenter [3] Kalender [5] Nyt fra tidsskrifterne [+20] Aktuelle smitsomme sygdomme [+20]
Dokumenter [3]
National klinisk guideline, Dansk Selskab for Gastroenterologi og Hepatologi (DSGH), Dansk Selskab for Klinisk Immunologi (DSKI), Dansk Selskab for Klinisk Mikrobiologi (DSKM) og Dansk Selskab for Infektionsmedicin (DSI)
Kalender [5]
21. marts, Fredericia
17. juni 2021, Online
27. september 2019, Rigshospitalet, auditorium 93, København
2. maj 2014, Hindsgavl, Middelfart
27. oktober 2011, Auditorium 1, Rigshospitalet
Nyt fra tidsskrifterne [+20]
Der er mere end 20 resultater, måske du vil se flere resultater her?Clinical Infectious Diseases
13.09.2024
Fecal microbiota transplantationClostridioides difficile infectionrandomized controlled trial
Clinical Infectious Diseases
1.09.2024
Abstract . Clostridioides difficile (C. difficile) is a spore-forming, toxin-producing, anaerobic bacterium infecting the human gastrointestinal tract, causing diarrhea and life-threatening colitis. C. difficile epidemiology continues to evolve, and it is recognized as a major community-associated pathogen in addition to its established role in causing healthcare-associated infection. While current surveillance and prevention measures mainly focus on healthcare-associated C. difficile infections, much less …
Clinical Microbiology and Infection
29.08.2024
Clostridioides difficile (C. difficile) remains the leading cause of healthcare-associated diarrhoea, posing treatment challenges due to antibiotic resistance and high relapse rates. Fecal microbiota transplantation (FMT) is a novel treatment strategy to prevent relapses of C. difficile infection (CDI), however the exact components conferring colonisation resistance are unknown, hampering its translation to a medicinal product. Development of novel products independent of antibiotics, which increase colonis…
Clinical Infectious Diseases
24.08.2024
Journal of Infectious Diseases
24.08.2024
Abstract . Background . Microbiota-based treatments are effective in preventing recurrent Clostridioides difficile infection (rCDI). Fecal microbiota, live-jslm (REBYOTA®; RBL, previously RBX2660) was shown to prevent rCDI in a phase 3, randomized, double-blinded placebo controlled clinical trial (PUNCH™ CD3).Methods . Stool samples from participants in PUNCH™ CD3 who received a single blinded dose of rectally administered RBL or placebo were sequenced to determine microbial community composition and c…
Antimicrobial Agents And Chemotherapy
22.08.2024
Antimicrobial Agents and Chemotherapy, Ahead of Print.
Journal of Infectious Diseases
10.08.2024
Abstract . Background . Clostridioides difficile is a major cause of nosocomial post-antibiotic infections, often resulting in severe inflammation and watery diarrhea. Previous studies have highlighted the role of C. difficile flagellin FliC in activating the TLR5 receptor and triggering NF-κB cell signaling, leading to the release of pro-inflammatory cytokines. However, the microRNAs (miRNAs) mediated regulatory mechanisms underlying the FliC-induced inflammatory response remain unclear.Methods . miRNA ex…
Clinical Microbiology and Infection
8.08.2024
The objective of this study is to examine the comparative effectiveness of vancomycin and metronidazole in a confirmatory analysis of event-free survival (EFS) following initial infection in patients with Clostridioides difficile (C. difficile) from a German multicentre cohort study.
BMC Infectious Diseases
30.07.2024
. Abstract. . Background. Clostridioides difficile infection is associated with antibiotic use and manifests as diarrhea; however, emerging cases of fulminant diarrhea caused by binary toxin-producing C. difficile unrelated to prior antibiotic exposure have been reported. Although fulminant colitis caused by C. difficile has been documented, instances of intussusception remain scarce. Here, we present a case of adult intussu…
BMC Infectious Diseases
17.07.2024
. Abstract. . Introduction. Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea. Fidaxomicin and fecal microbiota transplantation (FMT) are effective, but expensive therapies to treat recurrent CDI (reCDI). Our objective was to develop a prediction model for reCDI based on the gut microbiota composition and clinical characteristics, to identify patients who could benefit from …
BMC Infectious Diseases
11.07.2024
. Abstract. . Introduction. Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea. Fidaxomicin and fecal microbiota transplantation (FMT) are effective, but expensive therapies to treat recurrent CDI (reCDI). Our objective was to develop a prediction model for reCDI based on the gut microbiota composition and clinical characteristics, to identify patients who could benefit from …
Antimicrobial Agents And Chemotherapy
3.07.2024
Antimicrobial Agents and Chemotherapy, Ahead of Print.
BMC Infectious Diseases
25.06.2024
. Abstract. . Background. In the last two decades, a significant increase in the number of Clostridioides difficile infection (CDI) cases has been observed. It is understandable to attempt to determine the factors that can predict the severity of the course of the infection and identify patients at risk of death. This study aimed to analyze the factors affecting the incidence and mortality of CDI in inpatient treatment at th…
Microbiology and Molecular Biology Reviews
13.06.2024
Microbiology and Molecular Biology Reviews, Ahead of Print.
BMC Infectious Diseases
1.06.2024
. Abstract. . Background. Clostridioides difficile infections (CDIs) and recurrences (rCDIs) remain a major public health challenge due to substantial mortality and associated costs. This study aims to generate real-world evidence on the mortality and economic burden of CDI in Germany using claims data between 2015 and 2019. . . . Methods. A…
Journal of Infectious Diseases
24.05.2024
Abstract . Background . The use of fidaxomicin is recommended as first line therapy for all patients with Clostridioides difficile infection (CDI). However, real-world studies have shown conflicting evidence of superiority.Methods . We conducted a retrospective single center study of patients diagnosed with CDI between 2011-2021. A primary composite outcome of clinical failure, 30-day relapse or CDI-related death was used. A multivariable cause specific Cox proportional hazards model was used to evaluate fi…
BMC Infectious Diseases
23.05.2024
. Abstract. . Aim. Diarrhea is a common disease in immunocompromised patients and can be associated with greater morbidity and even mortality. Therefore, the present study was designed to determine the prevalence of Aeromonas spp., Campylobacter spp., and C. difficile among immunocompromised children. . . . Methods. This study was conducted …
Clinical Infectious Diseases
15.05.2024
Abstract . Background . Antibiotics are a strong risk factor for Clostridioides difficile infection (CDI), and CDI incidence is often measured as an important outcome metric for antimicrobial stewardship interventions aiming to reduce antibiotic use. However, risk of CDI from antibiotics varies by agent and dependent on the intensity (i.e., spectrum and duration) of antibiotic therapy. Thus, the impact of stewardship interventions on CDI incidence is variable, and understanding this risk requires a more gra…
BMC Infectious Diseases
8.05.2024
. Abstract. . Background. Clostridioides difficile infection (CDI) causes a major burden to individuals and society, yet the impact may vary depending on age, sex, underlying comorbidities and where CDI was acquired (hospital or community). . . . Methods. This Swedish nationwide population-based cohort study (2006–2019) compared all 43,150…
Journal of Infectious Diseases
3.05.2024
Abstract . Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF production and its association with a common genetic variant in leptin receptor (LEPR) using blood from patients with CDI. We found highest plasma MIF early after C difficile exposure and in individuals who ex…
Aktuelle smitsomme sygdomme [+20]
Der er mere end 20 resultater, måske du vil se flere resultater her?Eurosurveillance latest updates
9.02.2024
. Background. Community-associated Clostridioides difficile infections (CA-CDI) have increased worldwide. Patients with CDI-related symptoms occurring
ProMED
10.05.2023
Foodborne Illness -- JapanThe city of Kobe (capital of Hyogo Prefecture) announced on 9 May 2023 that 24 residents of Kobe Yuyu no Sato, a paid nursing home for the elderly in Naruko, Kita Ward, complained of symptoms such as diarrhea and abdominal pain.Since _Clostridium perfringens_ was detected in the stools of some patients, the city determined that it was foodborne illness and ordered the kitchen to stop providing meals for 3 days until 11 May 2023. All, aged 76 to 103, are recovering.--Communicated
ProMED
17.04.2023
Foodborne Illness -- Spain'The role of spices as vehicles of foodborne illness prompted an examination of bacterial spores in these products. Here, we report on the levels and characteristics of spores of _Clostridium perfringens_ associated with 247 retail spices in the USA. 43 confirmed isolates from 17% of samples were obtained, present at levels ranging from 3.6 to 2400 [organisms]/g. 27 (63%) of _C. perfringens_ isolates were positive for the enterotoxin gene ( cpe). 7 random spice isolates produced en…
ProMED
26.12.2022
Other Animal Disease -- United KingdomTwo leading livestock vets are urging farmers to vaccinate their livestock this winter for clostridial diseases as more animals are outwintered and vaccine boosters missed.Vets Joe Henry of Black Sheep Farm Health and Fiona Lovatt of Flock Health say as sheep and cattle are grazed for longer periods, and on crops such as fodder beet and swedes, the risks may be increased.This is due to exposure to the soil where clostridial spores are often present.Vaccine supply issues…
Eurosurveillance latest updates
8.12.2022
. Background. Since 2008, Danish national surveillance of Clostridioides difficile has focused on binary toxin-positive strains in order to monitor epidemic types such as PCR ribotype (RT) 027 and 078. Additional surveillance is needed to provide a more unbiased representation of all strains from the clinical reservoir. Aim. Setting up a new sentinel surveillance scheme for an improved understanding of type distribution relative to time, geography and epidemiology, here presenting data from 2016 to 2019. Me…
ProMED
7.10.2022
Foodborne Illness -- Japan
Eurosurveillance latest updates
30.06.2022
. Background. There is a paucity of data on community-based Clostridioides difficile infection (CDI) and how these compare with inpatient CDI. . . Aim. To compare data on the populations with CDI in hospitals vs the community across 12 European countries. . . Methods. For this point-prevalence study (July–November 2018), testing sites sent residual diagnostic material on sampling days to a coordinating laboratory for CDI testing and PCR ribotyping (n = 3,163). Information on whet…
Morbidity and Mortality Weekly Report (MMWR)
19.05.2022
This report describes an E. coli outbreak associated with a swimming pool.
ProMED
5.05.2022
Clostridium perfringens enterotoxin (CPE) -- Israel
Eurosurveillance latest updates
14.04.2022
. Background. While human-to-human transmission of Clostridioides difficile occurs often, other infection sources, including food, animals and environment, are under investigation. . . Aim. We present a large study on C. difficile in a food item in Europe, encompassing 12 European countries (Austria, France, Greece, Ireland, Italy, the Netherlands, Poland, Slovakia, Spain, Sweden, Romania and the United Kingdom). . . Methods. Potato was selected because of availability, ease of sampling and high C…
Eurosurveillance latest updates
9.02.2024
. Background. Community-associated Clostridioides difficile infections (CA-CDI) have increased worldwide. Patients with CDI-related symptoms occurring
ProMED
26.12.2022
Other Animal Disease -- United KingdomTwo leading livestock vets are urging farmers to vaccinate their livestock this winter for clostridial diseases as more animals are outwintered and vaccine boosters missed.Vets Joe Henry of Black Sheep Farm Health and Fiona Lovatt of Flock Health say as sheep and cattle are grazed for longer periods, and on crops such as fodder beet and swedes, the risks may be increased.This is due to exposure to the soil where clostridial spores are often present.Vaccine supply issues…
Eurosurveillance latest updates
8.12.2022
. Background. Since 2008, Danish national surveillance of Clostridioides difficile has focused on binary toxin-positive strains in order to monitor epidemic types such as PCR ribotype (RT) 027 and 078. Additional surveillance is needed to provide a more unbiased representation of all strains from the clinical reservoir. Aim. Setting up a new sentinel surveillance scheme for an improved understanding of type distribution relative to time, geography and epidemiology, here presenting data from 2016 to 2019. Me…
Eurosurveillance latest updates
30.06.2022
. Background. There is a paucity of data on community-based Clostridioides difficile infection (CDI) and how these compare with inpatient CDI. . . Aim. To compare data on the populations with CDI in hospitals vs the community across 12 European countries. . . Methods. For this point-prevalence study (July–November 2018), testing sites sent residual diagnostic material on sampling days to a coordinating laboratory for CDI testing and PCR ribotyping (n = 3,163). Information on whet…
Medscape Infectious Diseases
24.05.2022
Researchers compared the agents for treating both initial and recurrent Clostridioides difficile infections in a Medicare population. .
Medscape Infectious Diseases
6.05.2022
A novel antibiotic therapy for Clostridioides difficile infection, currently dubbed CRS3123, has demonstrated narrower selectivity and reduced bacterial derangement in the gut compared with other antibiotics. .
ProMED
5.05.2022
Clostridium perfringens enterotoxin (CPE) -- Israel
Eurosurveillance latest updates
14.04.2022
. Background. While human-to-human transmission of Clostridioides difficile occurs often, other infection sources, including food, animals and environment, are under investigation. . . Aim. We present a large study on C. difficile in a food item in Europe, encompassing 12 European countries (Austria, France, Greece, Ireland, Italy, the Netherlands, Poland, Slovakia, Spain, Sweden, Romania and the United Kingdom). . . Methods. Potato was selected because of availability, ease of sampling and high C…
Medscape Infectious Diseases
4.10.2021
Clostridioides difficile is most often thought of as a disease acquired in healthcare facilities, but researchers find that shoe bottoms tell another story of transmission in communities.
Eurosurveillance latest updates
9.09.2021
…ified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP, was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridiumscidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.