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Dokumenter [3]
National klinisk guideline, Dansk Selskab for Gastroenterologi og Hepatologi (DSGH), Dansk Selskab for Klinisk Immunologi (DSKI), Dansk Selskab for Klinisk Mikrobiologi (DSKM) og Dansk Selskab for Infektionsmedicin (DSI)
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Clinical Infectious Diseases
23.04.2025
To the Editor—We appreciate the opportunity to respond to the concerns raised by the various correspondents regarding details of our study. All correspondents note that our negative results contradict previous studies demonstrating the efficacy of fecal microbiota transplantation (FMT). Drs.
Clinical Infectious Diseases
23.04.2025
To the editor—We read with great interest the recent study by Drekonja et al [1], who assessed the efficacy of fecal microbiota transplantation (FMT) versus placebo in a large cohort of patients with Clostridioides difficile infection (CDI).
Clinical Infectious Diseases
23.04.2025
the National Institute of Health Research (NIHR) Imperial Biomedical Research Centre (BRC)Imperial College London10.13039/501100000761Imperial College Healthcare NHS Trust10.13039/501100000762Medical Research Council10.13039/501100000265MR/Z504002/1
Clinical Infectious Diseases
23.04.2025
…As developers of the encapsulated fecal microbiota formulation being tested, we read with interest and chagrin the report of the placebo-controlled clinical trial entitled “A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplanted for Preventing Recurrent Clostridioides difficile Infection” by Drekonja and colleagues [1]. We believe the paper underscores the importance of clinicians knowing the natural history of the disease and the pharmacology of the drug used to treat it.
Clinical Infectious Diseases
19.04.2025
Abstract . Background . Clostridioides difficile infection (CDI) primarily affects older patients with comorbid conditions and has a high mortality rate. Fecal microbiota transplantation (FMT) is effective and cost-effective for CDI. In a recent study, we demonstrated the clinical benefits of combining hospital-at-home care with FMT for older patients with CDI, but its cost-effectiveness remains unknown.
Clinical Infectious Diseases
12.04.2025
Proceedings of the National Academy of Sciences
10.04.2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 14, April 2025. SignificanceClostridioides difficileinfection is a hospital and antibiotics-associated bacterial infection which poses a major public health threat. One therapeutic route avoids antibiotics by targeting the bacteria’s source of pathogenesis:.
International Journal of Infectious Diseases
2.04.2025
… have demonstrated efficacy in reducing neonatal complications including necrotizing enterocolitis (NEC), all-cause mortality, late-onset sepsis, and feeding intolerance [2]. Clostridium butyricum (C. butyricum) is a strict anaerobe, producing butyric acid as a metabolic byproduct, hence also called butyric acid bacteria. C. butyricum live capsule (brand name: Baoluan, manufactured by Qingdao Donghai Pharmaceutical Co., Ltd., formulation: 500mg/bag, each bag containing no less than 5.0 × 10^6 CFU of C.
New England Journal of Medicine
28.03.2025
New England Journal of Medicine, Volume 392, Issue 12, Page 1237-1240, March 27, 2025.
BMC Infectious Diseases
20.03.2025
…d Clostridium celerecrescens as the causative pathogen. The patient fully recovered after surgical debridement and two weeks of antibiotic therapy. . Conclusions. Infections caused by C. celerecrescens are exceedingly rare in clinical practice. This case highlights the bacterium’s ability to adhere to a bamboo foreign body, leading to the formation of a rare brain abscess. mNGS proves to be a valuable diagnostic tool for identifying uncommon infectious agents.
BMC Infectious Diseases
7.03.2025
. Objective. To identify the source of Clostridium botulinum (C. botulinum) involved in a food poisoning case in Kunming and analyze its molecular characteristics. . Results. This study examined samples from a clustered food poisoning incident, including pickled pig liver consumed by three patients, hospital vomit from a deceased patient, and household waste mixed with vomit.
Clinical Infectious Diseases
6.03.2025
Abstract . Background . There have been several recent reports of Clostridioides difficile infection (CDI) due to isolates with reduced fidaxomicin susceptibility (minimum inhibitory concentration [MIC] ≥ 2 µg/mL). However, the clinical implications are uncertain because fidaxomicin achieves high concentrations in the intestinal tract.Methods .
Antimicrobial Agents And Chemotherapy
25.02.2025
Antimicrobial Agents and Chemotherapy, Ahead of Print.
Antimicrobial Agents And Chemotherapy
22.02.2025
Antimicrobial Agents and Chemotherapy, Ahead of Print.
FEMS Microbiology Reviews
10.02.2025
…ctivity and can remain dormant for years. Nevertheless, they can sense the environment and germinate quickly upon exposure to various germinants. Germinated spores can then outgrow into vegetative cells. Germination of spores of some anaerobes, especially Clostridioides difficile, is triggered by cholic acid and taurocholic acid. Elevated levels of these bile acids are thought to correlate with a perturbed gut microbiome, which cannot efficiently convert primary bile acids into secondary bile acids.
BMC Infectious Diseases
10.02.2025
. Abstract. Clostridioides difficile is the predominant pathogen in hospital-acquired infections and antibiotic-associated diarrhea. Dedicated networks and annual reports for C. difficile surveillance have been established in Europe and North America, however the extensive investigation on the prevalence of C. difficile infection (CDI) in China is limited.
Clinical Microbiology and Infection
28.01.2025
Increasing resistance to antimicrobials used for the treatment of Clostridioides difficile infections necessitates reproducible antimicrobial susceptibility testing. Current guidelines take a one-size-fits-all approach and/or offer limited guidance. We investigated how the choice of medium affects measured MIC values across two sites.
Clinical Microbiology and Infection
25.01.2025
Faecal microbiota transplantation (FMT) is an established treatment for recurrent Clostridioides difficile infection (R-CDI). This study aimed to identify calprotectin and microbiome characteristics as potential biomarkers of FMT success.
Clinical Infectious Diseases
20.01.2025
Abstract . Importance . The natural history of C. difficile progression in nucleic acid amplification test (NAAT) positive, toxin enzyme immunoassay-negative patients remains poorly described. Better understanding risk for subsequent disease may improve prevention strategies.Objective . Describe the natural history of C. difficile NAAT+/toxin- adults.Design . A cohort of adults (≥18 years) tested for C.
International Journal of Infectious Diseases
15.01.2025
Clostridioides difficile infection (CDI) represents the most common cause of healthcare-associated infectious diarrhoea [1], contributing to significant morbidity [2–4]. Cancer patients are particularly vulnerable to CDI owing to prolonged hospitalizations and exposure to multiple and recurrent antibiotics and chemotherapeutic agents. These treatments induce structural and functional changes in the gut microbiome increasing risks for C. difficile colonization [5,6].
Aktuelle smitsomme sygdomme [7]
Aktuelle smitsomme sygdomme [7]
ProMED
20.01.2025
. . . FOODBORNE ILLNESS - SPAIN: (CORDOBA) POSSIBLE CLOSTRIDIUM PERFRINGENS. *********************************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Wed 15 Jan 2025 . Source: El País [in Spanish, machine trans., edited] .
Eurosurveillance latest updates
11.01.2025
. Background. Clostridioides difficile infection (CDI) is a severe infection that needs to be monitored. This infection predominantly occurs in hospitalised patients after antimicrobial treatment, with high mortality in elderly patients. . . Aim. We aimed at estimating the incidence of CDI in Italian hospitals over 4 months in 2022. . . Methods.
ProMED
5.03.2025
… of livestock experts led by Deputy Director Dr Mohsin Bhatti. visited the affected areas to assess the crisis and ensure timely. treatment. . A detailed inspection of multiple farms revealed severe management. deficiencies, exposure to toxic substances, clostridial infection and. respiratory disease symptoms. To determine the exact cause, samples of. blood, silage, fodder and feed have been collected for laboratory. analysis. . With input from the Vehari assistant disease investigation officer,.
ProMED
19.02.2025
… . -- . Communicated by: . ProMED . [The etiology or etiologies of this nursing home cluster of illnesses. with deaths are not clear. It would be useful to know the incubation. period from the meal ingestion and first symptoms of illness. Salmonellosis, _Clostridium perfringens_ or _Staphylococcus aureus_. enterotoxin illnesses and norovirus are all possibilities. The elderly. and infirmed are more susceptible to the morbidities and mortality of. these illnesses. - Mod.LL . ProMED map:. Tuscany, Italy:.
ProMED
14.02.2025
…B treatment is unlikely to be. nephrotoxic in adequately hydrated horses receiving IV fluids. . 'The use of GI protectants such as bismuth subsalicylate and activated. charcoal have shown little benefit. Di-tri-octahedral smectite has. been shown to bind clostridial toxins, and the yeast _Saccharomyces. boulardii_ has shown benefit in treating colitis in humans. . 'Prevention of Salmonellosis in Horses . Prevention of salmonellosis is difficult, because the organism is.
ProMED
12.02.2025
…n, death and incomplete/non-recovery from. SARS-CoV-2 in an ambulatory global population . ICOS and PCOS Study Groups et al. Int J Infect Dis. 2025;151:107285 . doi.org/10.1016/j.ijid.2024.107285 . . Epidemiology and risk factors for mortality in clostridial bacteremia. in Japan: a retrospective multicenter observational study . Okazaki et al. Int J Infect Dis. 2025;151:107358 . doi.org/10.1016/j.ijid.2024.107358 . . Tuberculosis infection prevalence and treatment completion among.
ProMED
15.01.2025
…tynews.com/2025/01/pickled-eggs-linked-to-chinese-botulism-cases/ . . . Pickled eggs linked to Chinese botulism cases . --------------------------------------------- . Five people fell sick in China recently after eating pickled eggs. contaminated with _Clostridium botulinum_. In July 2024, 2 people with. suspected foodborne botulism went to the emergency department of a. hospital in Shandong Province. The patients had consumed homemade. pickled eggs. The Huancui District CDC and Weihai CDC initiated.