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Dokumenter [3]
National klinisk guideline, Dansk Selskab for Gastroenterologi og Hepatologi (DSGH), Dansk Selskab for Klinisk Immunologi (DSKI), Dansk Selskab for Klinisk Mikrobiologi (DSKM) og Dansk Selskab for Infektionsmedicin (DSI)
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New England Journal of Medicine
28.03.2025
New England Journal of Medicine, Volume 392, Issue 12, Page 1237-1240, March 27, 2025.
BMC Infectious Diseases
20.03.2025
…d Clostridium celerecrescens as the causative pathogen. The patient fully recovered after surgical debridement and two weeks of antibiotic therapy. . Conclusions. Infections caused by C. celerecrescens are exceedingly rare in clinical practice. This case highlights the bacterium’s ability to adhere to a bamboo foreign body, leading to the formation of a rare brain abscess. mNGS proves to be a valuable diagnostic tool for identifying uncommon infectious agents.
BMC Infectious Diseases
7.03.2025
. Objective. To identify the source of Clostridium botulinum (C. botulinum) involved in a food poisoning case in Kunming and analyze its molecular characteristics. . Results. This study examined samples from a clustered food poisoning incident, including pickled pig liver consumed by three patients, hospital vomit from a deceased patient, and household waste mixed with vomit.
Clinical Infectious Diseases
6.03.2025
Abstract . Background . There have been several recent reports of Clostridioides difficile infection (CDI) due to isolates with reduced fidaxomicin susceptibility (minimum inhibitory concentration [MIC] ≥ 2 µg/mL). However, the clinical implications are uncertain because fidaxomicin achieves high concentrations in the intestinal tract.Methods .
Antimicrobial Agents And Chemotherapy
25.02.2025
Antimicrobial Agents and Chemotherapy, Ahead of Print.
Antimicrobial Agents And Chemotherapy
22.02.2025
Antimicrobial Agents and Chemotherapy, Ahead of Print.
FEMS Microbiology Reviews
10.02.2025
…ctivity and can remain dormant for years. Nevertheless, they can sense the environment and germinate quickly upon exposure to various germinants. Germinated spores can then outgrow into vegetative cells. Germination of spores of some anaerobes, especially Clostridioides difficile, is triggered by cholic acid and taurocholic acid. Elevated levels of these bile acids are thought to correlate with a perturbed gut microbiome, which cannot efficiently convert primary bile acids into secondary bile acids.
BMC Infectious Diseases
10.02.2025
. Abstract. Clostridioides difficile is the predominant pathogen in hospital-acquired infections and antibiotic-associated diarrhea. Dedicated networks and annual reports for C. difficile surveillance have been established in Europe and North America, however the extensive investigation on the prevalence of C. difficile infection (CDI) in China is limited.
Clinical Microbiology and Infection
28.01.2025
Increasing resistance to antimicrobials used for the treatment of Clostridioides difficile infections necessitates reproducible antimicrobial susceptibility testing. Current guidelines take a one-size-fits-all approach and/or offer limited guidance. We investigated how the choice of medium affects measured MIC values across two sites.
Clinical Microbiology and Infection
25.01.2025
Faecal microbiota transplantation (FMT) is an established treatment for recurrent Clostridioides difficile infection (R-CDI). This study aimed to identify calprotectin and microbiome characteristics as potential biomarkers of FMT success.
Clinical Infectious Diseases
20.01.2025
Abstract . Importance . The natural history of C. difficile progression in nucleic acid amplification test (NAAT) positive, toxin enzyme immunoassay-negative patients remains poorly described. Better understanding risk for subsequent disease may improve prevention strategies.Objective . Describe the natural history of C. difficile NAAT+/toxin- adults.Design . A cohort of adults (≥18 years) tested for C.
International Journal of Infectious Diseases
15.01.2025
Clostridioides difficile infection (CDI) represents the most common cause of healthcare-associated infectious diarrhoea [1], contributing to significant morbidity [2–4]. Cancer patients are particularly vulnerable to CDI owing to prolonged hospitalizations and exposure to multiple and recurrent antibiotics and chemotherapeutic agents. These treatments induce structural and functional changes in the gut microbiome increasing risks for C. difficile colonization [5,6].
Nature
2.01.2025
Clinical Microbiology and Infection
9.12.2024
To study the presence of Clostridioides difficile in faeces of patients with recurrent C. difficile infection (rCDI) before and after faecal microbiota transplantation (FMT) and to identify risk factors for faecal C. difficile and CDI recurrence.
International Journal of Infectious Diseases
7.12.2024
Clostridium species are spore-forming, gram-positive bacilli widely distributed in nature, including soil, and intestinal tracts of humans and animals [1,2]. To date, approximately 200 Clostridium spp. have been identified. Clostridium spp. cause enteritis, skin and soft tissue infections, peritonitis, and bacteremia [1,2]. In particular, the incidence of bacteremia caused by Clostridium spp. is high among older adults with comorbidities [3,4]. Clostridium spp.
Proceedings of the National Academy of Sciences: Immunology and Inflammation
2.12.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 45, November 2024.
International Journal of Infectious Diseases
26.11.2024
… C. difficile, specifically in fulminant disease where outcomes are poor [1,2]. About 17% of patients with Clostridioides difficile infection (CDI) experience relapse within 2-8 weeks; in severe or fulminant cases, 20% require colectomy and up to 35% will die [3,4]. Tigecycline (TGC) is a tetracycline-derivative antibiotic that has been recommended as an adjunct therapy in fulminant CDI if patients lack response to SOC antibiotics, but there are limited data exploring patient outcomes in this setting [5,6].
Trends in Microbiology
19.10.2024
Clostridium perfringens is a Gram-positive, anaerobic, rod-shaped bacterium that causes various diseases in humans and animals, resulting in significant economic losses worldwide. This bacterium forms heat- and chemical-resistant metabolically dormant spores which can survive in a wide range of environments, including soil, sediment, sewage, food, and the intestinal tracts of humans and animals. In favorable conditions, C.
Infection
9.10.2024
. Abstract. Gas gangrene is a rare presentation of a necrotizing fasciitis, caused by Clostridium perfringens, C. septicum and other clostridial species. With its rapid progression it is a potentially life-threatening infection, that poses as a challenge in the clinical management requiring an interdisciplinary approach. .
Science
4.10.2024
Science, Volume 386, Issue 6717, Page 69-75, October 2024.
Aktuelle smitsomme sygdomme [7]
Aktuelle smitsomme sygdomme [7]
ProMED
20.01.2025
. . . FOODBORNE ILLNESS - SPAIN: (CORDOBA) POSSIBLE CLOSTRIDIUM PERFRINGENS. *********************************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Wed 15 Jan 2025 . Source: El País [in Spanish, machine trans., edited] .
Eurosurveillance latest updates
11.01.2025
. Background. Clostridioides difficile infection (CDI) is a severe infection that needs to be monitored. This infection predominantly occurs in hospitalised patients after antimicrobial treatment, with high mortality in elderly patients. . . Aim. We aimed at estimating the incidence of CDI in Italian hospitals over 4 months in 2022. . . Methods.
ProMED
5.03.2025
… of livestock experts led by Deputy Director Dr Mohsin Bhatti. visited the affected areas to assess the crisis and ensure timely. treatment. . A detailed inspection of multiple farms revealed severe management. deficiencies, exposure to toxic substances, clostridial infection and. respiratory disease symptoms. To determine the exact cause, samples of. blood, silage, fodder and feed have been collected for laboratory. analysis. . With input from the Vehari assistant disease investigation officer,.
ProMED
19.02.2025
… . -- . Communicated by: . ProMED . [The etiology or etiologies of this nursing home cluster of illnesses. with deaths are not clear. It would be useful to know the incubation. period from the meal ingestion and first symptoms of illness. Salmonellosis, _Clostridium perfringens_ or _Staphylococcus aureus_. enterotoxin illnesses and norovirus are all possibilities. The elderly. and infirmed are more susceptible to the morbidities and mortality of. these illnesses. - Mod.LL . ProMED map:. Tuscany, Italy:.
ProMED
14.02.2025
…B treatment is unlikely to be. nephrotoxic in adequately hydrated horses receiving IV fluids. . 'The use of GI protectants such as bismuth subsalicylate and activated. charcoal have shown little benefit. Di-tri-octahedral smectite has. been shown to bind clostridial toxins, and the yeast _Saccharomyces. boulardii_ has shown benefit in treating colitis in humans. . 'Prevention of Salmonellosis in Horses . Prevention of salmonellosis is difficult, because the organism is.
ProMED
12.02.2025
…n, death and incomplete/non-recovery from. SARS-CoV-2 in an ambulatory global population . ICOS and PCOS Study Groups et al. Int J Infect Dis. 2025;151:107285 . doi.org/10.1016/j.ijid.2024.107285 . . Epidemiology and risk factors for mortality in clostridial bacteremia. in Japan: a retrospective multicenter observational study . Okazaki et al. Int J Infect Dis. 2025;151:107358 . doi.org/10.1016/j.ijid.2024.107358 . . Tuberculosis infection prevalence and treatment completion among.
ProMED
15.01.2025
…tynews.com/2025/01/pickled-eggs-linked-to-chinese-botulism-cases/ . . . Pickled eggs linked to Chinese botulism cases . --------------------------------------------- . Five people fell sick in China recently after eating pickled eggs. contaminated with _Clostridium botulinum_. In July 2024, 2 people with. suspected foodborne botulism went to the emergency department of a. hospital in Shandong Province. The patients had consumed homemade. pickled eggs. The Huancui District CDC and Weihai CDC initiated.