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Proceedings of the National Academy of Sciences, 13.03.2023
Tilføjet 21.03.2023
Proceedings of the National Academy of Sciences, Volume 120, Issue 12, March 2023.
Læs mere Tjek på PubMedProceedings of the National Academy of Sciences, 13.03.2023
Tilføjet 21.03.2023
Proceedings of the National Academy of Sciences, Volume 120, Issue 12, March 2023.
Læs mere Tjek på PubMedProceedings of the National Academy of Sciences, 14.03.2023
Tilføjet 21.03.2023
Proceedings of the National Academy of Sciences, Volume 120, Issue 12, March 2023.
Læs mere Tjek på PubMedProceedings of the National Academy of Sciences, 14.03.2023
Tilføjet 21.03.2023
Proceedings of the National Academy of Sciences, Volume 120, Issue 12, March 2023.
Læs mere Tjek på PubMedProceedings of the National Academy of Sciences, 15.03.2023
Tilføjet 21.03.2023
Proceedings of the National Academy of Sciences, Volume 120, Issue 12, March 2023.
Læs mere Tjek på PubMedFEMS Microbiology Reviews, 21.03.2023
Tilføjet 21.03.2023
AbstractPower-to-X (P2X) technologies will play a more important role in the conversion of electric power to storable energy carriers, commodity chemicals and even food and feed. Among the different P2X technologies, microbial components form cornerstones of individual process steps. This review comprehensively presents the state-of-the-art of different P2X technologies from a microbiological standpoint. We are focusing on microbial conversions of hydrogen from water electrolysis to methane, other chemicals and proteins. We present the microbial toolbox needed to gain access to these products of interest, assess its current status and research needs, and discuss potential future developments that are needed to turn todays P2X concepts into tomorrow's technologies.
Læs mere Tjek på PubMedFEMS Microbiology Reviews, 21.03.2023
Tilføjet 21.03.2023
AbstractTerpenoids, also known as isoprenoids, are the largest and most diverse class of organic compounds in nature and are involved in many membrane-associated cellular processes, including membrane organization, electron transport chain, cell signaling, and phototrophy. Terpenoids are ancient compounds with their origin presumably before the last universal common ancestor. However, Bacteria and Archaea are known to possess two distinct terpenoid repertoires and utilize terpenoids differently. Most notably, Archaea constitute their cellular membrane solely made of terpenoid-based phospholipids, contrary to the bacterial membrane that consists of fatty acid-based phospholipids. Thus, the composition of ancestral membranes at the beginning of cellular life and the diversification of terpenoids in early life remain enigmatic. This review addresses these key issues through comprehensive phylogenomic analyses of extant terpenoid biosynthesis enzymes in Bacteria and Archaea. We aim to infer the basal components of terpenoid biosynthesis machinery that have an ancient origin before the divergence of the two domains and shed light on the deep evolutionary connection between terpenoid biochemistry and early life.
Læs mere Tjek på PubMedClinical Infectious Diseases, 21.03.2023
Tilføjet 21.03.2023
AbstractBackgroundLung transplantation is one of the only options for patients with severe COVID-19-associated lung injury (CALI). Studies on patients who received a lung transplant for CALI have, to date, not looked at the infectious outcomes.MethodsAfter IRB approval, a retrospective case-control cohort study, matched 1:1, collected data on patients who underwent lung transplantation for CALI (case) and for non-COVID-19 end-stage lung disease (control) between June 1, 2020 and April 1, 2022 at a large academic hospital in Chicago. We assessed infectious complications and other key outcomes pre-transplant and for one-year post-transplant.ResultsAmong 78 subjects (39 CALI and 39 matched control lung transplant patients), those in the CALI cohort were less likely to be vaccinated pre-transplant and were more likely to have diabetes, obesity, to not be ambulatory and to require pre-transplant ECMO and mechanical ventilation. Patients transplanted for CALI had higher rates of infection pre-transplant (66.7% vs 15.4% of patients in the control) and in the first 30 days post-transplant (43.6% vs. 20.5%). Numbers and types of infection were similar in both groups at other time points. One year mortality was similar (12.8% vs. 10.3%) for CALI and control populations, respectively.ConclusionsPatients who received a lung transplant for CALI are more deconditioned with prolonged hospital stays and experience more infectious complications immediately pre- and post-transplant. Infections due to MDROs are important contributors to morbidity and mortality in this population and antimicrobial stewardship is urgently needed.
Læs mere Tjek på PubMedClinical Infectious Diseases, 21.03.2023
Tilføjet 21.03.2023
Clinical Infectious Diseases, 21.03.2023
Tilføjet 21.03.2023
AbstractBackgroundOlder adults are recommended to receive influenza vaccination annually and many use statins. Statins have immunomodulatory properties that might modify influenza vaccine effectiveness (VE) and alter influenza infection risk.MethodsUsing the test-negative design and linked laboratory and health administrative databases in Ontario, Canada, we estimated VE against laboratory-confirmed influenza among community-dwelling statin users and non-users aged ≥66 years during the 2010-2011 to 2018-2019 influenza seasons. We also estimated the odds ratio (OR) for influenza infection between statin users and non-users by vaccination status.ResultsAmong subjects tested for influenza across the 9 seasons, 54,243 had continuous statin exposure prior to testing and 48,469 were deemed unexposed. VE against laboratory-confirmed influenza was similar between statin users and non-users (17% [95%CI, 13-20%] and 17% [95%CI, 13-21%] respectively; test for interaction, p=0.87). In both vaccinated and unvaccinated subjects, statin users had higher odds of laboratory-confirmed influenza than non-users (OR for vaccinated =1.15; 95%CI, 1.10-1.21; OR for unvaccinated=1.15; 95%CI, 1.10-1.20). These findings were consistent by mean daily dose and statin type. VE did not differ between users and non-users of other cardiovascular drugs, except for beta-blockers. We did not observe that vaccinated and unvaccinated users of these drugs had increased odds of influenza, except for unvaccinated beta-blocker users.ConclusionsInfluenza VE did not differ between statin users and non-users. Statin use was associated with increased odds of laboratory-confirmed influenza in vaccinated and unvaccinated subjects, but these associations might be impacted by residual confounding.
Læs mere Tjek på PubMedBMJ Open, 20.03.2023
Tilføjet 21.03.2023
ObjectivesTo explore the acceptability of regular asymptomatic testing for SARS-CoV-2 on a university campus using saliva sampling for PCR analysis and the barriers and facilitators to participation.DesignCross-sectional surveys and qualitative semistructured interviews.SettingEdinburgh, Scotland.ParticipantsUniversity staff and students who had registered for the testing programme (TestEd) and provided at least one sample.Results522 participants completed a pilot survey in April 2021 and 1750 completed the main survey (November 2021). 48 staff and students who consented to be contacted for interview took part in the qualitative research. Participants were positive about their experience with TestEd with 94% describing it as ‘excellent’ or ‘good’. Facilitators to participation included multiple testing sites on campus, ease of providing saliva samples compared with nasopharyngeal swabs, perceived accuracy compared with lateral flow devices (LFDs) and reassurance of test availability while working or studying on campus. Barriers included concerns about privacy while testing, time to and methods of receiving results compared with LFDs and concerns about insufficient uptake in the university community. There was little evidence that the availability of testing on campus changed the behaviour of participants during a period when COVID-19 restrictions were in place.ConclusionsThe provision of free asymptomatic testing for COVID-19 on a university campus was welcomed by participants and the use of saliva-based PCR testing was regarded as more comfortable and accurate than LFDs. Convenience is a key facilitator of participation in regular asymptomatic testing programmes. Availability of testing did not appear to undermine engagement with public health guidelines.
Læs mere Tjek på PubMedBMJ Open, 20.03.2023
Tilføjet 21.03.2023
ObjectivesThis study aims to compare the clinical manifestations, laboratory findings, outcomes and overall survival time of patients with COVID-19 with and without comorbidities.DesignRetrospective design.SettingThis study was undertaken at two hospitals in Damascus.ParticipantsA total of 515 Syrian patients met the inclusion criterion, laboratory-confirmed COVID-19 infection following the Centers for Disease Control and Prevention. Exclusion criteria were suspected and probable cases that were not confirmed with a positive reverse transcription-PCR assay, and patients who self-discharged from the hospital against medical advice.Primary and secondary outcome measuresFirst, assess the impacts of comorbidities on COVID-19 infection in four areas (clinical manifestations, laboratory findings, severity and outcomes). Second, calculate the overall survival time for patients with COVID-19 with comorbidities.ResultsOf 515 patients included, 316 (61.4%) were male and 347 (67.4%) had at least one coexisting chronic disease. Patients with comorbidities compared with no comorbidities were more vulnerable to poor outcomes such as severe infection (32.0% vs 9.5%, p<0.001), severe complications (34.6% vs 9.5%, p<0.001), the need for mechanical ventilation (28.8% vs 7.7%, p<0.001) and death (32.0% vs 8.3%, p<0.001). Multiple logistic regression showed that age ≥65 years old, positive smoking history, having ≥2 comorbidities and chronic obstructive pulmonary disease were risk factors linked to severe COVID-19 infection in patients with comorbidities. Overall survival time was lower among patients with comorbidities (vs no comorbidities), patients with ≥2 comorbidities (vs one comorbidity), and patients with hypertension, chronic obstructive pulmonary disease, malignancy or obesity (vs other comorbidities) (p<0.05).ConclusionThis study revealed that COVID-19 infection had poor outcomes among those with comorbidities. Severe complications, mechanical ventilation usage and death were more prevalent among patients with comorbidities compared with those with no comorbidities.
Læs mere Tjek på PubMedBMJ Open, 20.03.2023
Tilføjet 21.03.2023
IntroductionCancer diagnosis and treatment can impair fertility, and younger female patients with cancer have a particularly strong need for fertility preservation. Fertility preservation decision aids are thought to help patients make proactive and informed treatment decisions. This systematic review aims to assess the effectiveness and feasibility of online fertility preservation decision aids for young female patients with cancer.Methods and analysisPubMed, Web of Science Core Collection, Embase, The Cochrane Central Register of Controlled Trials, PsycINFO and CHINAL, along with three grey literature sources (Google Scholar, ClinicalTrials.gov and WHO International Clinical Trials Registry Platform), will be searched from each database’s establishment to 30 November 2022. Two trained reviewers will independently screen the articles, and the data extraction and methodological quality of eligible randomised controlled trials and quasiexperimental studies will be assessed. A meta-analysis will be performed using Review Manager V.5.4 (Cochrane Collaboration) software, and heterogeneity will be assessed using I² statistics. If a meta-analysis is not possible, a narrative synthesis will be done.Ethics and disseminationSince this systematic review is based on published data, no ethical approval is required. The study’s findings will be disseminated through peer-reviewed publications and conference presentations.PROSPERO registration numberCRD42022363287.
Læs mere Tjek på PubMedSamiha Benrabaa, Ian Orchard, Angela B. Lange
PLoS One Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
by Samiha Benrabaa, Ian Orchard, Angela B. LangeEcdysteroids control ovary growth and egg production through a complex gene hierarchy. In the female Rhodnius prolixus, a blood-gorging triatomine and the vector of Chagas disease, we have identified the ecdysone response genes in the ovary using transcriptomic data. We then quantified the expression of the ecdysone response gene transcripts (E75, E74, BR-C, HR3, HR4, and FTZ-F1) in several tissues, including the ovary, following a blood meal. These results confirm the presence of these transcripts in several tissues in R. prolixus and show that the ecdysone response genes in the ovary are mostly upregulated during the first three days post blood meal (PBM). Knockdown of E75, E74, or FTZ-F1 transcripts using RNA interference (RNAi) was used to understand the role of the ecdysone response genes in vitellogenesis and egg production. Knockdown significantly decreases the expression of the transcripts for the ecdysone receptor and Halloween genes in the fat body and the ovaries and reduces the titer of ecdysteroid in the hemolymph. Knockdown of each of these transcription factors typically alters the expression of the other transcription factors. Knockdown also significantly decreases the expression of vitellogenin transcripts, Vg1 and Vg2, in the fat body and ovaries and reduces the number of eggs produced and laid. Some of the laid eggs have an irregular shape and smaller volume, and their hatching rate is decreased. Knockdown also influences the expression of the chorion gene transcripts Rp30 and Rp45. The overall effect of knockdown is a decrease in number of eggs produced and a severe reduction in number of eggs laid and their hatching rate. Clearly, ecdysteroids and ecdysone response genes play a significant role in reproduction in R. prolixus.
Læs mere Tjek på PubMedVulstan James Shedura, Ally Kassim Hussein, Salum Kassim Nyanga, Doreen Kamori, Geofrey Joseph Mchau
PLoS One Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
by Vulstan James Shedura, Ally Kassim Hussein, Salum Kassim Nyanga, Doreen Kamori, Geofrey Joseph MchauBackground The World Health Organization (WHO) recommends periodic evaluations of influenza surveillance systems to identify areas for improvement and provide evidence of data reliability for policymaking. However, data on the performance of established influenza surveillance systems are limited in Africa, including Tanzania. We aimed to assess the usefulness of the Influenza surveillance system in Tanzania and to ascertain if the system meets its objectives, including; estimating the burden of disease caused by the Influenza virus in Tanzania and identifying any circulating viral strains with pandemic potential. Methodology From March to April 2021, we collected retrospective data through a review of the Tanzania National Influenza Surveillance System electronic forms for 2019. Furthermore, we interviewed the surveillance personnel about the system’s description and operating procedures. Case definition (ILI-Influenza Like Illness and SARI-Severe Acute Respiratory Illness), results, and demographic characteristics of each patient were obtained from the Laboratory Information System (Disa*Lab) at Tanzania National Influenza Center. The United States Centers for disease control and prevention updated guidelines for evaluating public health surveillance systems were used to evaluate the system’s attributes. Additionally, the system’s performance indicators (including turnaround time) were obtained by evaluating Surveillance system attributes, each being scored on a scale of 1 to 5 (very poor to excellent performance). Results A total of 1731 nasopharyngeal and oropharyngeal samples were collected from each suspected influenza case in 2019 from fourteen (14/14) sentinel sites of the influenza surveillance system in Tanzania. Laboratory-confirmed cases were 21.5% (373/1731) with a predictive value positive of 21.7%. The majority of patients (76.1%) tested positive for Influenza A. Thirty-seven percent of patients’ results met the required turnaround time, and 40% of case-based forms were incompletely filled. Although the accuracy of the data was good (100%), the consistency of the data was below (77%) the established target of ≥ 95%. Conclusion The overall system performance was satisfactory in conforming with its objectives and generating accurate data, with an average performance of 100%. The system’s complexity contributed to the reduced consistency of data from sentinel sites to the National Public Health Laboratory of Tanzania. Improvement in the use of the available data could be made to inform and promote preventive measures, especially among the most vulnerable population. Increasing sentinel sites would increase population coverage and the level of system representativeness.
Læs mere Tjek på PubMedLinda Carman Copel, Suzanne C. Smeltzer, Christine D. Byrne, Mu-Hsun Chen, Donna S. Havens, Peter Kaufmann, Heather Brom, Jennifer Dean Durning, Linda Maldonado, Patricia K. Bradley, Janell Mensinger, Jennifer Yost
PLoS One Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
by Linda Carman Copel, Suzanne C. Smeltzer, Christine D. Byrne, Mu-Hsun Chen, Donna S. Havens, Peter Kaufmann, Heather Brom, Jennifer Dean Durning, Linda Maldonado, Patricia K. Bradley, Janell Mensinger, Jennifer YostAims and objectives Studies have shown that the COVID-19 pandemic has taken a toll on individuals who interact with patients with SARS-CoV-2 but focused largely on clinicians in acute care settings. This qualitative descriptive study aimed to understand the experiences and well-being of essential workers across settings during the pandemic. Background Multiple studies of the well-being of individuals who have cared for patients during the pandemic have included interviews of clinicians from acute care settings and revealed high levels of stress. However, other essential workers have not been included in most of those studies, yet they may also experience stress. Methods Individuals who participated in an online study of anxiety, depression, traumatic distress, and insomnia, were invited to provide a free-text comment if they had anything to add. A total of 2,762 essential workers (e.g., nurses, physicians, chaplains, respiratory therapists, emergency medical technicians, housekeeping, and food service staff, etc.) participated in the study with 1,079 (39%) providing text responses. Thematic analysis was used to analyze those responses. Results Four themes with eight sub-themes were: Facing hopelessness, yet looking for hope; Witnessing frequent death; Experiencing disillusionment and disruption within the healthcare system, and Escalating emotional and physical health problems. Conclusions The study revealed major psychological and physical stress among essential workers. Understanding highly stressful experiences during the pandemic is essential to identify strategies that ameliorate stress and prevent its negative consequences. This study adds to the research on the psychological and physical impact of the pandemic on workers, including non-clinical support personnel often overlooked as experiencing major negative effects. Relevance to clinical practice The magnitude of stress among all levels of essential workers suggests the need to develop strategies to prevent or alleviate stress across disciplines and all categories of workers.
Læs mere Tjek på PubMedYi-Tseng Tsai, Sriyani Padmalatha K. M., Han-Chang Ku, Yi-Lin Wu, Nai-Ying Ko
PLoS One Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
by Yi-Tseng Tsai, Sriyani Padmalatha K. M., Han-Chang Ku, Yi-Lin Wu, Nai-Ying KoDeath by suicide is a major public health problem. People living with human immunodeficiency virus (PLHIV) have higher risk of suicidal behavior than the general population. The aim of this review is to summarize suicidal behavior, associated risk factors, and risk populations among PLHIV. Research studies in six databases from January 1, 1988, to July 8, 2021, were searched using keywords that included “HIV,” “suicide,” and “risk factors.” The study design, suicide measurement techniques, risk factors, and study findings were extracted. A total of 193 studies were included. We found that the Americas, Europe, and Asia have the highest rates of suicidal behavior. Suicide risk factors include demographic factors, mental illness, and physiological, psychological, and social support. Depression is the most common risk factor for PLHIV, with suicidal ideation and attempt risk. Drug overdosage is the main cause of suicide death. In conclusion, the current study found that PLHIV had experienced a high level of suicidal status. This review provides an overview of suicidal behavior and its risk factors in PLHIV with the goal of better managing these factors and thus preventing death due to suicide.
Læs mere Tjek på PubMedCallam T. Davidson, Eileen Miller, Morwenna Muir, John C. Dawson, Martin Lee, Stuart Aitken, Alan Serrels, Scott P. Webster, Natalie Z. M. Homer, Ruth Andrew, Valerie G. Brunton, Patrick W. F. Hadoke, Brian R. Walker
PLoS One Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
by Callam T. Davidson, Eileen Miller, Morwenna Muir, John C. Dawson, Martin Lee, Stuart Aitken, Alan Serrels, Scott P. Webster, Natalie Z. M. Homer, Ruth Andrew, Valerie G. Brunton, Patrick W. F. Hadoke, Brian R. WalkerGlucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angiogenesis in murine models of myocardial infarction. Angiogenesis is important in the growth of some solid tumours. This study used murine models of squamous cell carcinoma (SCC) and pancreatic ductal adenocarcinoma (PDAC) to test the hypothesis that 11β-HSD1 inhibition promotes angiogenesis and subsequent tumour growth. SCC or PDAC cells were injected into female FVB/N or C57BL6/J mice fed either standard diet, or diet containing the 11β-HSD1 inhibitor UE2316. SCC tumours grew more rapidly in UE2316-treated mice, reaching a larger (P
Læs mere Tjek på PubMedBMC Infectious Diseases, 21.03.2023
Tilføjet 21.03.2023
Abstract Background Nasopharyngeal swabs are taken to determine the causative agent of community acquired pneumonia (CAP), while the reliability of upper respiratory tract sampling as a proxy for lower respiratory tract infections is still unclear. Methods Nasopharyngeal (NP) swabs, bronchoalveolar lavage (BAL) fluid samples and clinical data were collected from 153 hospitalized children between 3 months and 14 years of age with severe CAP, enrolled from March to June 2019. Written informed consent for the storage and use of the samples for further studies was obtained from the parents or caregivers. Putative pathogens were detected using a sensitive, high-throughput GeXP-based multiplex PCR and qPCR. Results The same bacterial species in paired samples were found in 29 (23.4%) and the same viral species in 52 (27.5%) of the patients. moderate concordance was found for Mycoplasma pneumoniae (ĸ=0.64), followed by Haemophilus influenzae (ĸ=0.42). The strongest discordance was observed for human adenovirus and also for Pseudomonas aeruginosa, the latter was exclusively detected in BAL samples. In the adenovirus cases strong concordance was associated with high viral loads in the NP swabs. Conclusion The variation in concordance in pathogen detection in the upper and lower respiratory tract of children with severe pneumonia is generally high but varies depending on the species. Novel and impactful insights are the concordance between NP and BAL detection for M. pneumoniae and H. influenzae and the strong correlation between high adenoviral loads in NP swabs and detection in BAL fluid.
Læs mere Tjek på PubMedMalaria Journal, 21.03.2023
Tilføjet 21.03.2023
Abstract Background Understanding Plasmodium falciparum population diversity and transmission dynamics provides information on the intensity of malaria transmission, which is needed for assessing malaria control interventions. This study aimed to determine P. falciparum allelic diversity and multiplicity of infection (MOI) among asymptomatic and symptomatic school-age children in Kinshasa Province, Democratic Republic of Congo (DRC). Methods A total of 438 DNA samples (248 asymptomatic and 190 symptomatic) were characterized by nested PCR and genotyping the polymorphic regions of pfmsp1 block 2 and pfmsp2 block 3. Results Nine allele types were observed in pfmsp1 block2. The K1-type allele was predominant with 78% (229/293) prevalence, followed by the MAD20-type allele (52%, 152/293) and RO33-type allele (44%, 129/293). Twelve alleles were detected in pfmsp2, and the 3D7-type allele was the most frequent with 84% (256/304) prevalence, followed by the FC27-type allele (66%, 201/304). Polyclonal infections were detected in 63% (95% CI 56, 69) of the samples, and the MOI (SD) was 1.99 (0.97) in P. falciparum single-species infections. MOIs significantly increased in P. falciparum isolates from symptomatic parasite carriers compared with asymptomatic carriers (2.24 versus 1.69, adjusted b: 0.36, (95% CI 0.01, 0.72), p = 0.046) and parasitaemia > 10,000 parasites/µL compared to parasitaemia < 5000 parasites/µL (2.68 versus 1.63, adjusted b: 0.89, (95% CI 0.46, 1.25), p < 0.001). Conclusion This survey showed low allelic diversity and MOI of P. falciparum, which reflects a moderate intensity of malaria transmission in the study areas. MOIs were more likely to be common in symptomatic infections and increased with the parasitaemia level. Further studies in different transmission zones are needed to understand the epidemiology and parasite complexity in the DRC.
Læs mere Tjek på PubMedInfection and Immunity, 20.03.2023
Tilføjet 21.03.2023
Infection and Immunity, 20.03.2023
Tilføjet 21.03.2023
Infection and Immunity, 20.03.2023
Tilføjet 21.03.2023
Infection and Immunity, 20.03.2023
Tilføjet 21.03.2023
Infection and Immunity, 20.03.2023
Tilføjet 21.03.2023
International Journal of Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
The emergence of SARS-CoV-2 causing the prolonged COVID-19 pandemic has had profound public health and socio-economic consequences worldwide [1]. Throughout the course of the pandemic, the rapid mutation of SARS-CoV-2 has spawned numerous novel strains including variants of concern (VOCs) – further complicating infection control measures with altered transmissibility, virulence, and immune evasion [2,3]. Currently, the world is gradually transitioning to endemicity with the rapid spread and dominance of the Omicron VOC and its subvariants.
Læs mere Tjek på PubMedInternational Journal of Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
Peritonitis is a common complication of peritoneal dialysis (PD), which is significantly related to the mortality of PD patients [1]. Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum commonly colonize the urogenital tract [2]. PD-associated peritonitis caused by them has rarely been reported. Herein, we reported four cases of this disease and reviewed the literature.
Læs mere Tjek på PubMedInternational Journal of Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
Objectives We assessed the effect of inactivated COVID-19 vaccine boosting immunization on the viral shedding time for patients infected with the Omicron variant BA.2.Methods We performed a real-world study by analyzing outbreak data of patients infected with the COVID-19 Omicron variant BA.2 from March to May 2022 in Shanghai, China. Patients were categorized into three groups, including not fully vaccinated (0 and 1 dose), fully vaccinated (2 doses), and booster-vaccinated (3 doses).Results A total of 4443 patients infected with COVID-19 were included in the analysis.
Læs mere Tjek på PubMedInternational Journal of Infectious Diseases, 20.03.2023
Tilføjet 21.03.2023
Puumala virus (PUUV) is a hantavirus causing haemorrhagic fever with renal syndrome. Studies showing an increased risk of lymphoid malignancies following hantavirus infection, together with the observation that PUUV infects B cells motivated us to study the risk of lymphoid malignancies following PUUV infection.
Læs mere Tjek på PubMedInternational Journal of Infectious Diseases, 19.03.2023
Tilføjet 20.03.2023
Coronavirus Disease-19 (COVID 19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) are the two leading causes of death in the world [1–3].
Læs mere Tjek på PubMed