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Plague -- DR CongoOn 22 Feb 2020, the Aungba Health Zone chief medical doctor was alerted that suspect bubonic plague cases were reported in the Ugunzu-Makangi village of the Aterlembe health area, Djugu territory, Ituri Province, DR Congo. Murine epizootics were also mentioned in the Makangi village. On 23 Feb 2020, the chief medical doctor of the Aungba health Zone (Lat 2 33' 00'' Long 30 30' 00'') was appointed to visit the health center of Aterlembe for 2 days to investigate suspect bubonic plague cases.
Plague -- DR Congo
COVID-19 -- China1. Yu Wen-Bin, Tang Guang-da, Zhang Li, Corlett R. (2020). Decoding evolution and transmissions of novel pneumonia coronavirus (SARS-CoV-2) using the whole genomic data.2020. doi 10.12074/202002.00033. .- Mod.ASHealthMap/ProMED-mail map of China: ][See Also:COVID-19 update (11): animal reservoir, intermediate hosts, pangolin susp. http://promedmail.org/post/20200220.7009213COVID-19 update (08): companion animals, RFI http://promedmail.org/post/20200218.7002276COVID-19 update (06):
Morana Tomljenovic, Mato Lakic, Tatjana Vilibic-Cavlek, Sanja Kurecic Filipovic, Vesna Visekruna Vucina, Andrea Babic-Erceg, Miljenko Ljubic, Iva Pem Novosel, Maja Ilic, Irena Tabain, Jelena Ivancic-Jelecki, Lisa Hansen and Bernard Kaic
In May 2018, measles was introduced in the Dubrovnik region by an adult who recently travelled to Kosovo*. Control measures and an outbreak investigation were implemented: 15 epidemiologically-linked cases met the outbreak case definition of a visitor/resident of Dubrovnik-Neretva County with laboratory-confirmed measles and symptom onset beginning on May 19. New cases were identified through hospitals and primary care physicians. Throat swabs, urine and/or serum samples were collected from outbreak cases. RT-PCR detection of viral RNA and IgM/IgG was used to confirm infection. The median age of cases was 33 years, with one 8 month-old infant. Vaccination status was unknown for 9 cases, three were unvaccinated, one case had history of one dose and two cases reported receiving two doses of measles-containing vaccine. There were 11 hospitalisations and one person developed pneumonia. Control teams undertook an extensive search of contacts and implemented a range of control measures. Despite the outbreak occurring at the beginning of the summer tourism season, it was contained and did not spread to neighbouring regions. With continuing measles transmission in Europe, even small outbreaks create a burden on the health system in countries which have eliminated measles, and illustrate the importance of maintaining high immunisation coverage.
Pneumonia -- AfghanistanAt least 35 people including women and children have died in the past few weeks due to pneumonia outbreak in Badakhshan Province in the northwestern mountainous area, the provincial health department confirmed.Dr Noor Khawari, head of the provincial public health department, said [Sat 15 Feb 2020] that the people had died in the Wakhan district, a remote area surrounded by high and impassable mountains.He said that 15 of the dead were children, calling malnutrition and cold weather as
Lara Tavoschi, Silvia Forni, Andrea Porretta, Lorenzo Righi, Filippo Pieralli, Francesco Menichetti, Marco Falcone, Giulia Gemignani, Spartaco Sani, Paola Vivani, Tommaso Bellandi, Danilo Tacconi, Lucia Turini, Giulio Toccafondi, Gaetano Privitera, Pierluigi Lopalco, Angelo Baggiani, Fabrizio Gemmi, Grazia Luchini, Maurizio Petrillo, Lorenzo Roti, Patrizio Pezzotti, Annalisa Pantosti, Stefania Iannazzo, Maria Teresa Mechi, Gian Maria Rossolini and on behalf of the Tuscan Clinical Microbiology Laboratory Net
In Tuscany, Italy, New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacterales (NDM-CRE) have increased since November 2018. Between November 2018 and October 2019, 1,645 samples were NDM-CRE-positive: 1,270 (77.2%) cases of intestinal carriage, 129 (7.8%) bloodstream infections and 246 (14.9%) infections/colonisations at other sites. Klebsiella pneumoniae were prevalent (1,495; 90.9%), with ST147/NDM-1 the dominant clone. Delayed outbreak identification and response resulted in sustained NDM-CRE transmission in the North-West area of Tuscany, but successfully contained spread within the region.
In December of 2018, Wyoming identified the state's first case of carbapenem-resistant Enterobacteriaceae (CRE) containing mcr-1, which is a gene that can make bacteria resistant to colistin, a drug that can be the last resort for some multidrug-resistant infections like CRE.
Coronavirus -- ChinaChina's ability to control a rapidly spreading coronavirus epidemic is under further strain amid fears that a key test used to confirm new cases is failing to catch large numbers of people with the disease. Problems with so-called nucleic acid tests (NATs) widely used to identify the presence of the previously unknown pneumonia-causing virus make it likely that many infections are going uncounted even as the number of confirmed cases continues to spiral.Authorities are still struggling to
Ine Wouters, Stefanie Desmet, Liesbet Van Heirstraeten, Sereina A Herzog, Philippe Beutels, Jan Verhaegen, Herman Goossens, Pierre Van Damme, Surbhi Malhotra-Kumar, Heidi Theeten and NPcarriage Study Group
The current carriage study was set up to reinforce surveillance during/after the PCV13-to-PCVC10 switch in Belgium.
This observational study monitored carriage of Streptococcus pneumoniae (Sp) serotypes, particularly those no longer covered (3, 6A, 19A), as well as Haemophilus influenzae (Hi), because PCV10 contains the non-typeable Hi protein D.
A total of 2,615 nasopharyngeal swabs from children (6–30 months old) attending day care were collected in three periods over 2016–2018. Children’s demographic and clinical characteristics and vaccination status were obtained through a questionnaire. Sp and Hi were identified by culture and PCR. Pneumococcal strains were tested for antimicrobial (non-)susceptibility by disc diffusion and serotyped by Quellung-reaction (Quellung-reaction and PCR for serotypes 3, 6A, 19A).
The carriage prevalence of Sp (> 75%) remained stable over the successive periods but that of Hi increased (87.4%, 664 Hi-carriers/760 in 2016 vs 93.9%, 895/953 in 2017–2018). The proportion of non-PCV13 vaccine serotypes decreased (94.6%, 438 isolates/463 in 2016 vs 89.7%, 599/668 in 2017–2018) while that of PCV13-non-PCV10 vaccine serotypes (3 + 6A + 19A) increased (0.9%, 4 isolates/463 in 2016 vs 7.8%, 52/668 in 2017–2018), with serotype 19A most frequently identified (87.9%, 58/66 isolates). Non-susceptibility of pneumococci against any of the tested antibiotics was stable over the study period (> 44%).
During and after the PCV13-to-PCV10 vaccine switch, the proportion of non-PCV13 serotypes decreased, mainly due to a serotype 19A carriage prevalence increase. These results complement invasive pneumococcal disease surveillance data, providing further basis for pneumococcal vaccination programme policy making.
Jantien A Backer, Don Klinkenberg and Jacco Wallinga
A novel coronavirus (2019-nCoV) is causing an outbreak of viral pneumonia that started in Wuhan, China. Using the travel history and symptom onset of 88 confirmed cases that were detected outside Wuhan in the early outbreak phase, we estimate the mean incubation period to be 6.4 days (95% credible interval: 5.6–7.7), ranging from 2.1 to 11.1 days (2.5th to 97.5th percentile). These values should help inform 2019-nCoV case definitions and appropriate quarantine durations.
Coronavirus, Polio, Meningitis, Pneumonia, Tuberculosis, Dengue, Other Human Disease, Typhus, Hepatitis B, Chikungunya, Zika virus, Mumps, Measles, Rubella, Yellow Fever, West Nile Virus, Cytomegalovirus, HIV/AIDS, Malaria, Chagas, Avian Influenza, Legionnaires', Whooping Cough, Hepatitis E, Tick-borne Encephalitis, Hepatitis C -- ChinaThe continuing 2019-nCoV epidemic threat of novel coronaviruses to global health: the latest 2019 novel coronavirus outbreak in Wuhan, China.David S Hui, Esam I Azhar, Tariq A Madani, Francine Ntoumi, Richard Kock, Osman Dar, et al.Int J Infect Dis. 2020; 91(Feb): 264-266.Extra time and penalties in the polio endgame.Melinda Suchard, Oyewale Tomori, Lucille BlumbergInt J Infect Dis. 2020; 91(Feb): 252-254.Original reportsBacterial
Coronavirus -- Worldwide/UnknownProf Joseph T Wu, PhD, Kathy Leung, PhD, Prof Gabriel M Leung, MD. Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study.SummaryBackgroundSince 31 Dec 2019, the Chinese city of Wuhan has reported an outbreak of atypical pneumonia caused by the 2019 novel coronavirus (2019-nCoV). Cases have been exported to other Chinese cities, as well as internationally, threatening to trigger a global
Coronavirus -- ChinaRecently, some medical institutions found that many of the pneumonia cases received were related to South China Seafood City. After receiving the report, the Municipal Health and Health Commission immediately launched a case search and retrospective investigation related to South China Seafood City in the city's medical health institutions; 27 cases have been found, of which 7 are in serious condition, and the remaining cases are stable and controllable. Two patients are expected to be
Coronavirus -- ChinaCitation:Qun Li, M. Med., Xuhua Guan, PhD, Peng Wu, PhD, Xiaoye Wang, Lei Zhou, M.Med., Yeqing Tong, et al.: Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. New England Journal of Medicine. 2020; DOI: 10.1056/NEJMoa2001316AbstractBackgroundThe initial cases of novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, Hubei province, China, in December 2019 and January 2020. We analyzed data on the 1st 425 confirmed cases in
Julien Riou and Christian L. Althaus
Since December 2019, China has been experiencing a large outbreak of a novel coronavirus (2019-nCoV) which can cause respiratory disease and severe pneumonia. We estimated the basic reproduction number R0 of 2019-nCoV to be around 2.2 (90% high density interval: 1.4–3.8), indicating the potential for sustained human-to-human transmission. Transmission characteristics appear to be of similar magnitude to severe acute respiratory syndrome-related coronavirus (SARS-CoV) and pandemic influenza, indicating a risk of global spread.
Coronavirus -- China840 new cases of pneumonia caused by new coronavirus infection were added in Hubei Province (315 in Wuhan, 33 in Huangshi, 23 in Shiyan, and new [sic?] in Xiangyang). 61 new cases, 12 new cases in Yichang, 30 new cases in Jingzhou, 28 new cases in Jingmen, 27 new cases in Ezhou, 101 new cases in Xiaogan City, 111 new cases in Huanggang City, 21 new cases in Xianning City (46 cases in Suizhou City, 13 cases in Enshi Prefecture, 5 cases in Xiantao City, 11 cases in Tianmen City, 1 case in
Coronavirus -- ChinaOn [31 Dec 2019], WHO was informed of cases of pneumonia of unknown etiology (unknown cause) detected in Wuhan City, Hubei province of China. A novel coronavirus (2019-nCoV) was identified as the causative virus by Chinese authorities on [7 Jan 2020].Investigations are ongoing to evaluate the source of the outbreak, mode(s) of transmission, and the extent of infection. Available evidence on the 2019-nCoV virus and previous experience with other coronavirus (MERS-CoV and SARS-CoV) and other
Irene Galani, Ilias Karaiskos, Maria Souli, Vassiliki Papoutsaki, Lamprini Galani, Aikaterini Gkoufa, Anastasia Antoniadou and Helen Giamarellou
From September to October 2019, seven patients colonised or infected with a ceftazidime-avibactam (CZA)-resistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing K. pneumoniae were detected in two intensive care units of a Greek general hospital. The outbreak strain was sequence type (ST)147 and co-produced KPC-2 and the novel plasmid-borne Vietnamese extended-spectrum β-lactamase (VEB)-25 harbouring a K234R substitution associated with CZA resistance. Epidemiological investigations revealed that the resistance was probably acquired by horizontal transmission independently from previous CZA exposure.
Coronavirus -- ChinaAs of 24:00 on [22 Jan 2020], our committee had received a total of 571 confirmed cases of pneumonia of new coronavirus infection in 25 provinces (autonomous regions, municipalities) in China, including 95 severe cases and 17 deaths (all from Hubei Province). A total of 393 suspected cases were reported in 13 provinces (autonomous regions and municipalities).At 00:00 on [22 Jan 2020] 24 provinces (autonomous regions and municipalities) reported 131 new confirmed cases and 8 new deaths, of
Coronavirus -- ChinaAt 00:00 on [20 Jan 2020, our committee received 77 new cases of pneumonia diagnosed with new type of coronavirus infection in 3 domestic provinces (regions, municipalities) (72 in Hubei Province, 2 in Shanghai, and 3 in Beijing). Cases); 27 new suspected cases were reported in 9 provinces (districts, cities) (4 in Guangdong, 1 in Sichuan, 1 in Yunnan, 7 in Shanghai, 10 in Zhejiang, 1 in Anhui, and Hainan). 1 case, 1 case in Guizhou Province, and 1 case in Ningxia Hui Autonomous Region).As
Coronavirus -- ChinaSecond case of imported new coronavirus pneumonia confirmed in Shanghai. The patient is a 35-year-old male resident in Shanghai. He went to Wuhan on the evening of [8 Jan 2020] and returned to Shanghai on [11 Jan 2020]. He developed fever, cough, and runny nose. He was admitted to the hospital for isolation and treatment after attending a fever clinic on [16 Jan 2020]. After detection by the city's disease control department, the new coronavirus nucleic acid test result was positive. Expert
A Washington state man returning from Wuhan, the outbreak's epicenter, was hospitalized in good condition. The newly discovered virus can cause coughing, fever, breathing difficulty, and pneumonia.
Coronavirus -- ChinaAn unexplained pneumonia in China caused the Korean quarantine authorities to strengthen the quarantine, and a fever-sensing camera is installed to monitor the body temperature of Chinese tourists who entered Korea at Incheon Port 1 International Passenger Terminal. Pneumonia confirmed by the new coronavirus, which is prevalent in Wuhan, China, was confirmed for the first time on [20 Jan 2020]. According to health officials, a Chinese woman, A, who arrived at Incheon International Airport
Coronavirus -- ChinaOn [18 Jan 2020], 0 cases were cured, 5 cases were discharged, 59 cases were newly added, and 1 died. On [19 Jan 2020], 0-22 hours, 1 case was discharged, and 77 cases were newly added.On the basis of continuously regulating the operation of pre-screening and triage of all types of medical institutions at all levels, our city has further increased the screening of suspected cases of pneumonia due to new coronavirus in accordance with the newly revised pneumonia diagnosis and treatment plan
Coronavirus -- ChinaIssuing authority: Wuhan City health committeeOn [17 Jan 2020], national and provincial experts screened some cases of unexplained pneumonia that were screened by community health service centers in the city and found and treated [these cases] in various hospitals based on their clinical manifestations, epidemiological history, and optimization. The positive results of the novel coronavirus nucleic acid detected by the subsequent detection kit were comprehensively judged, and 17 cases of
Coronavirus -- ChinaMinistry of Public Health screening for travelers from Wuhan City, People's Republic of China found confirmed coronavirus pneumonia of the 2019 strain from a 2nd individual, which is currently under medical supervision at Bamrasnaradura Institute waiting for the results of repeated lab tests. There has been no outbreak of the new strain of the coronavirus in Thailand.Today ([17 Jan 2020]) at the Department of Disease Control of the Ministry of Public Health in Nonthaburi Province, Dr.
Michael L Beeton, Xu-Sheng Zhang, Søren A Uldum, Cécile Bébéar, Roger Dumke, Karolina Gullsby, Margareta Ieven, Katherine Loens, Ran Nir-Paz, Sabine Pereyre, O Brad Spiller, Victoria J Chalker and the ESCMID Study Group for Mycoplasma and Chlamydia Infections (ESGMAC) Mycoplasma pneumoniae subgroup
Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia, with large epidemics previously described to occur every 4 to 7 years.
To better understand the diagnostic methods used to detect M. pneumoniae; to better understand M. pneumoniae testing and surveillance in use; to identify epidemics; to determine detection number per age group, age demographics for positive detections, concurrence of epidemics and annual peaks across geographical areas; and to determine the effect of geographical location on the timing of epidemics.
A questionnaire was sent in May 2016 to Mycoplasma experts with national or regional responsibility within the ESCMID Study Group for Mycoplasma and Chlamydia Infections in 17 countries across Europe and Israel, retrospectively requesting details on M. pneumoniae-positive samples from January 2011 to April 2016. The Moving Epidemic Method was used to determine epidemic periods and effect of country latitude across the countries for the five periods under investigation.
Representatives from 12 countries provided data on M. pneumoniae infections, accounting for 95,666 positive samples. Two laboratories initiated routine macrolide resistance testing since 2013. Between 2011 and 2016, three epidemics were identified: 2011/12, 2014/15 and 2015/16. The distribution of patient ages for M. pneumoniae-positive samples showed three patterns. During epidemic years, an association between country latitude and calendar week when epidemic periods began was noted.
An association between epidemics and latitude was observed. Differences were noted in the age distribution of positive cases and detection methods used and practice. A lack of macrolide resistance monitoring was noted.
E. Voulgari, S.D. Kotsakis, P. Giannopoulou, E. Perivolioti, L.S. Tzouvelekis and V. Miriagou
Two ceftazidime-avibactam (CAZ-AVI)-resistant Klebsiella pneumoniae carbapenemase (KPC)-positive K. pneumoniae strains, including one pandrug resistant, were isolated in 2019 from two Greek hospitals. The strains were sequence types (ST)s 258 and 147 and both harboured similar self-transmissible IncA/C2 plasmids encoding a novel Lys234Arg variant of the Vietnamese extended-spectrum β-lactamase (VEB)-1, not inhibited by AVI (VEB-25). Conjugal transfer of VEB-25-encoding plasmids to Escherichia coli yielded CAZ-AVI-resistant clones, supporting that VEB-25 is directly linked to the derived phenotype.
Coronavirus -- ChinaAt 04:00 on [15 Jan 2020], there were no new cases of pneumonitis infected with new coronavirus in our city. A total of 5 patients were discharged from the hospital and 1 new death was reported. The deceased, a male, 69 years old, became ill on [31 Dec 2019], became worse on [4 Jan 2020] and was transferred to Wuhan Jinyintan Hospital for treatment. He was admitted with severe myocarditis (myocardial enzymes reached 20 times normal, electrocardiographic abnormalities); abnormal renal function;
Coronavirus -- ChinaThursday, [16 Jan 2020][Reference]Health Bureau Tuberculosis Infectious Disease SectionOffice of Infectious Disease Information ManagementOn [14 Jan 2020], a medical institution in Kanagawa Prefecture reported a case of pneumonia to a public health center under [its] jurisdiction [in an individual who had been in Wuhan, Hubei Province, China]. About this person, when he visited a medical institution on [6 Jan 2020], a report of his stay history in Wuhan was made. It was reported
Coronavirus -- ChinaThe new virus behind recent pneumonia cases in Wuhan is unlikely to cause a widespread, deadly epidemic like SARS [Severe acute respiratory syndrome], scientists say, as revelations that a Chinese tourist in Thailand had not visited the market linked to the outbreak raised fears of a potential spread of the disease.The woman, 61, who was confirmed by Thai authorities to have the new virus, had not visited the now-closed mainland seafood market associated with the outbreak, the Post learned
Pneumonia -- ChinaFurther to our letter dated [9 Jan 2020], we would like to update you with the latest situation of the reported cluster of pneumonia cases in Wuhan, Hubei Province.After the preliminary determination that the pathogen of "viral pneumonia with unknown cause" is a novel coronavirus, the expert groups have immediately revised and improved the protocols on diagnosis, treatment and surveillance of viral pneumonia with unknown cause. The Wuhan Municipal Health Commission has arranged the samples
Coronavirus -- ChinaOn Twitter and other forums, pressure is growing on China to share genetic sequences and other details about the new coronavirus implicated this week in an unexplained pneumonia outbreak in Wuhan.So far, the only official announcements on cases came from Wuhan's health commission, which hasn't released any updates since [Sun 5 Jan 2020]. The announcements of preliminary identification of a new coronavirus have come mainly from tightly controlled Chinese media reports quoting Chinese
Coronavirus -- ChinaChinese authorities have made a preliminary determination of a novel (or new) coronavirus, identified in a hospitalized person with pneumonia in Wuhan. Chinese investigators conducted gene sequencing of the virus, using an isolate from one positive patient sample. Preliminary identification of a novel virus in a short period of time is a notable achievement and demonstrates China's increased capacity to manage new outbreaks.Initial information about the cases of pneumonia in Wuhan provided
Pneumonia -- ChinaSince [31 Dec 2019], the Centre for Health Protection of the Department of Health has received reports of a total of 30 cases under the enhanced surveillance system with recent travel history to Wuhan, Hubei (as of [7 Jan 2020], 12:00 noon).[The first 21 cases were reported in Undiagnosed pneumonia - China (04): (HU) Hong Kong surveillance http://promedmail.org/post/20200106.6874277]Case no.: Date of report / Gender / Age / Source of reporting / Name of hospital / Positive laboratory
Coronavirus -- ChinaA few days ago, on the issue of the pathogenic identification of unexplained viral pneumonia epidemic in Wuhan, the reporter interviewed Xu Jianguo, the leader of the preliminary assessment of pathogenic test results and a member of the Chinese Academy of Engineering. He said that the expert group believed that the pathogen of this unexplained case of viral pneumonia was initially determined to be a new coronavirus.Question 1: At present, what progress has been made in the pathogenic
Coronavirus -- ChinaChinese scientists investigating a mystery illness that has sickened dozens in central China have discovered a new strain of coronavirus, a development that will test the country's upgraded capabilities for dealing with unfamiliar infectious diseases.The novel coronavirus was genetically sequenced from a sample from 1 patient and subsequently found in some of the others affected in the city of Wuhan, according to people familiar with the findings. Chinese authorities haven't concluded that
Pneumonia -- ChinaHealth experts warned the public on Monday [6 Jan 2020] not to drop their guard over the unidentified outbreak of viral pneumonia in central China, even though the health authorities have ruled out highly contagious viruses such as Severe Acute Respiratory Syndrome (SARS) or bird flu. On Monday [6 Jan 2020] the local health authorities in Wuhan said that work to identify the virus, which has so far infected 59 people in the city, was continuing, but that SARS, Middle East Respiratory
Undiagnosed -- ChinaOn [31 Dec 2019], the WHO China Country Office was informed of cases of pneumonia of unknown etiology (unknown cause) detected in Wuhan City, Hubei Province of China. As of [3 Jan 2020], a total of 44 patients with pneumonia of unknown etiology have been reported to WHO by the national authorities in China. Of the 44 cases reported, 11 are severely ill, while the remaining 33 patients are in stable condition. According to media reports, the concerned market in Wuhan was closed on [1 Jan 2020]
On 31 December 2019, the WHO China Country Office was informed of cases of pneumonia of unknown etiology (unknown cause) detected in Wuhan City, Hubei Province of China. As of 3 January 2020, a total of 44 patients with pneumonia of unknown etiology have been reported to WHO by the national authorities in China. Of the 44 cases reported, 11 are severely ill, while the remaining 33 patients are in stable condition. According to media reports, the concerned market in Wuhan was closed on 1 January 2020 for environmental sanitation and disinfection. The causal agent has not yet been identified or confirmed. On 1 January 2020, WHO requested further information from national authorities to assess the risk.
Pneumonia -- ChinaThe World Health Organisation said it is in ongoing contact with authorities in China over an unidentified outbreak of viral pneumonia in the central city of Wuhan, amid concern it may have been transmitted from animals.Wuhan health authorities on Tuesday [31 Dec 2019] said 27 people - most of them stallholders at the Huanan Seafood Wholesale Market - had been treated in hospital, with 7 said to be in serious condition. Pathology tests were under way to try and identify the virus,
Tuberculosis, Antimicrobial resistance, Other Human Disease, Pneumonia, Respiratory Syncytial Virus, Q Fever, HIV/AIDS, Measles, Influenza, Dengue, Hepatitis B, Hantavirus, Gastroenteritis, Schistosomiasis, Leishmaniasis, Chikungunya, Rickettsia -- SyriaFrequent testicular involvement in multibacillary leprosyHendra Gunawan, Pati Aji Achdiat, Rachel Marsella Rahardjo, Reti Hindritiani, Oki SuwarsaInternational Journal of Infectious Diseases, Volume 90, January 2020, pp. 60-64Antibiotic use among hospitalized adult patients in a setting with limited laboratory infrastructure in Freetown Sierra Leone, 2017-2018Sulaiman Lakoh, Olukemi Adekanmbi, Darlinda F. Jiba, Gibrilla F. Deen, Wadzani Gashau, Stephen Sevalie, Eili Y.
SARS -- ChinaOn the evening of [30 Dec 2019], an "urgent notice on the treatment of pneumonia of unknown cause" was issued, which was widely distributed on the Internet by the red-headed document of the Medical Administration and Medical Administration of Wuhan Municipal Health Committee.On the morning of [31 Dec 2019], China Business News reporter called the official hotline of Wuhan Municipal Health and Health Committee 12320 and learned that the content of the document is true.12320 hotline
Sebastian Haller, Rolf Kramer, Karsten Becker, Jürgen A Bohnert, Tim Eckmanns, Jörg B Hans, Jane Hecht, Claus-Dieter Heidecke, Nils-Olaf Hübner, Axel Kramer, Kathleen Klaper, Martina Littmann, Lennart Marlinghaus, Bernd Neumann, Yvonne Pfeifer, Niels Pfennigwerth, Simone Rogge, Katharina Schaufler, Andrea Thürmer, Guido Werner and Sören Gatermann
From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to K. pneumoniae sequence type 307. Control measures and further investigations are ongoing.
Equine Herpes Virus -- United StatesHerpesvirus is highly contagious among horses and can cause a variety of ailments in equids, including rhinopneumonitis (a respiratory disease usually found in young horses), abortion in broodmares, and EHM [equine herpesvirus myeloencephalopathy].In many horses, the 1st or only sign of EHV-1 infection is fever, which can go undetected. In addition to fever, other common signs of EHV-1 infection in young horses include cough, decreased appetite, depression, and a nasal discharge. Pregnant
Marius Linkevicius, Veronica Cristea, Lotta Siira, Henna Mäkelä, Maija Toropainen, Marjaana Pitkäpaasi, Timothee Dub, Hanna Nohynek, Taneli Puumalainen, Esa Rintala, Merja E. Laaksonen, Thijs Feuth, Juha O. Grönroos, Jutta Peltoniemi, Heikki Frilander, Irmeli Lindström and Jussi Sane
We report an outbreak of invasive pneumococcal disease and pneumococcal pneumonia among shipyard workers, in Turku, Southwest Finland. In total, 31 confirmed and six probable cases were identified between 3 May and 28 November 2019. Streptococcus pneumoniae serotypes 12F, 4 and 8 were isolated from blood cultures of 25 cases. Occupational hygiene measures and vaccination of ca 4,000 workers are underway to control the outbreak at the shipyard.
Plague -- ChinaA new pneumonic plague case has been confirmed in Ulanqab, northern China's Inner Mongolia Autonomous Region, after a herdsman was diagnosed on Wed 27 Nov 2019. The city is over 500 km [about 311 mi] away from Xilingol League in the region, where the other 3 pneumonic plague cases were previously found.The patient, who had visited a region where plague sources were identified, was being treated in isolation and was in a stable condition at the Siziwang Banner People's Hospital in Ulanqab,
Not Yet Classified -- Worldwide/UnknownBacterial infectionsA translational pharmacokinetic/pharmacodynamic model to characterize bacterial kill in the presence of imipenem-relebactam.Pratik Bhagunde, Zufei Zhang, Fred Racine, Donna Carr, Jin Wu, Katherine Young, et al.Int J Infect Dis. 2019; 89(Dec): 55-61.The accuracy of a diagnosis of pneumonia in the emergency department.Alaa Atamna, Shachaf Shiber, Muhammad Yassin, Michael J Drescher, Jihad Bishara.Int J Infect Dis. 2019; 89(Dec): 62-65.Monitoring the
Pneumonia -- CanadaA Canadian teenager developed a life-threatening condition known as "popcorn lung" after several months of intense vaping, in the 1st medical case linking this chronic lung disease to e-cigarette use.Popcorn lung, or popcorn worker's lung, is so-called because the condition was 1st documented in 2000 among microwave-popcorn factory workers who were exposed to the flavouring chemical diacetyl. The disease, more formally known as bronchiolitis obliterans, has also been documented among
Benedikt Zacher, Sebastian Haller, Niklas Willrich, Jan Walter, Muna Abu Sin, Alessandro Cassini, Diamantis Plachouras, Carl Suetens, Michael Behnke, Petra Gastmeier, Lothar H. Wieler and Tim Eckmanns
Healthcare-associated infections (HAIs) pose a major challenge to health systems. Burden of disease estimations in disability-adjusted life years (DALYs) are useful for comparing and ranking HAIs.
To estimate the number of five common HAIs, their attributable number of deaths and burden for Germany.
We developed a new method and R package that builds on the approach used by the Burden of Communicable Diseases in Europe (BCoDE) project to estimate the burden of HAIs for individual countries. We used data on healthcare-associated Clostridioides difficile infection, healthcare-associated pneumonia, healthcare-associated primary bloodstream infection, healthcare-associated urinary tract infection and surgical-site infection, which were collected during the point prevalence survey of HAIs in European acute-care hospitals between 2011 and 2012.
We estimated 478,222 (95% uncertainty interval (UI): 421,350–537,787) cases for Germany, resulting in 16,245 (95% UI: 10,863–22,756) attributable deaths and 248,920 (95% UI: 178,693–336,239) DALYs. Despite the fact that Germany has a relatively low hospital prevalence of HAIs compared with the European Union/European Economic Area (EU/EEA) average, the burden of HAIs in Germany (308.2 DALYs/100,000 population; 95% UI: 221.2–416.3) was higher than the EU/EEA average (290.0 DALYs/100,000 population; 95% UI: 214.9–376.9). Our methodology is applicable to other countries in or outside of the EU/EEA. An R package is available from https://CRAN.R-project.org/package=BHAI.
This is the first study to estimate the burden of HAIs in DALYs for Germany. The large number of hospital beds may be a contributing factor for a relatively high burden of HAIs in Germany. Further focus on infection prevention control, paired with reduction of avoidable hospital stays, is needed to reduce the burden of HAIs in Germany.
Dansk Selskab for Intern Medicin (DSIM) årsmøde og overrækkelse af Hagedorn prisen 2020
Novo Nordisk Fonden, Tuborg Havnevej 19, 2900 Hellerup
Conference on Retroviruses and Opportunistic Infections (CROI) 2020
Boston, Massachusetts, USA
8.03.2020 - 11.03.2020
Når CROI går i fisk - med transmissioner fra CROI 2020
10.03.2020 - 11.03.2020
World TB day 2020
Specialespecifikt kursus om kardiopulmonale infektioner og TB
26.03.2020 - 27.03.2020
National handlingsplan for antibiotika til mennesker (2017)
Retningslinjer til sundhedsprofessionelle vedr. håndtering af infektion med zikavirus (2019)
Antiviral behandling af hiv smittede personer (2019)
Varicella Zoster Virus encephalitis in Denmark from 2015 to 2019- A nationwide prospective cohort study
27.02.2020Clinical Infectious Diseases Advance Access
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