Ingen søgeord valgt.
20 emner vises.
1
Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity
Daniele Carvalho Nascimento, Paula Ramos Viacava, Raphael Gomes Ferreira, Marina Alves Damaceno, Annie Rocío Piñeros, Paulo Henrique Melo, Paula Barbim Donate, Juliana Escher Toller-Kawahisa, Daniel Zoppi, Flávio Protásio Veras, Raphael Sanches Peres, Luísa Menezes-Silva, Diego Caetité, Antonio Edson Rocha Oliveira, Ícaro Maia Santos Castro, Gilles Kauffenstein, Helder Imoto Nakaya, Marcos Carvalho Borges, Dario Simões Zamboni, Denise Morais Fonseca, Jonas Augusto Rizzato Paschoal, Thiago Mattar Cunha, Valerie Quesniaux, Joel Linden, Fernando Queíroz Cunha, Bernhard Ryffel, José Carlos Alves-Filho
Immunity, 1.09.2021
Tilføjet 1.09.2021
Sepsis causes immunosuppression and increased susceptibility to infection by unknown means. Nascimento et al. show sepsis-induced expansion of a CD39hi plasmablast population that elevated circulating adenosine. Adenosine signaling in macrophages suppressed microbial killing and promoted IL-10 production. This work highlights CD39hi plasmablasts and adenosine as important drivers of sepsis-induced immunosuppression.
Læs mere
Tjek på PubMed
2
On the First World Field Epidemiology Day, Honoring Our Disease Detectives on the Front Lines
Angela Hilmers
International Journal of Infectious Diseases, 1.09.2021
Tilføjet 1.09.2021
“Everything we face has a history, and everything we do has a future”William “Bill” Foege
Læs mere
Tjek på PubMed
3
Relationship between serotypes, disease characteristics and 30-day mortality in adults with invasive pneumococcal disease
Infection, 1.09.2021
Tilføjet 1.09.2021
Abstract
Purpose
Invasive pneumococcal disease (IPD) is responsible for substantial mortality and morbidity worldwide. We aimed to identify host and bacterial factors associated with 30-day mortality in 18-year-old patients hospitalized with IPD in France from 2013 to 2015.
Methods
This study analyzed data collected from consecutives IPD cases included in two parallel multi-center cohort studies: COMBAT study (280 patients with pneumococcal community-acquired bacterial meningitis) and SIIP study (491 patients with non-meningitis IPD). Factors associated with 30-day mortality were identified using logistic regression.
Results
Among the 771 enrolled patients (median age 66 years, IQR [52.0–79.7]), 592/767 (77.2%) had at least one chronic disease. Patients with meningitis were younger (60.2 vs 70.9 years; p < 0.001) and had fewer chronic diseases than those with non-meningitis IPD (73.3% vs 79.4%; p = 0.05). Non-vaccine serotypes were more frequent in meningitis patients than in those with other IPD (36.1% vs 23.1%; p < 0.001). The overall 30-day mortality was 16.7% and patients with concurrent meningitis and extra-cerebral IPD had the highest 30-day mortality rate (26.5%). On multivariate analyses, older age, history of malignant solid tumor, meningeal IPD and serotypes previously identified with high mortality potential were independently associated with 30-day mortality. Of the serotypes with high mortality potential, 80% were included in licensed (PCV13 or PPV23) vaccines.
Conclusion
We observed an effect of both host factors and pneumococcal serotypes on 30-day mortality in IPD. This highlights the need for a focused strategy to vaccinate at-risk patients.
Clinical trial
ClinicalTrial. Gov identification number: NCT01730690
Læs mere
Tjek på PubMed
4
COVID-19 in young and middle-aged adults: predictors of poor outcome and clinical differences
Infection, 31.08.2021
Tilføjet 1.09.2021
Abstract
Introduction
Young and middle-aged adults are the largest group of patients infected with SARS-CoV-2 and some of them develop severe disease.
Objective
To investigate clinical manifestations in adults aged 18–65 years hospitalized for COVID-19 and identify predictors of poor outcome. Secondary objectives: to explore differences compared to the disease in elderly patients and the suitability of the commonly used community-acquired pneumonia prognostic scales in younger populations.
Methods
Multicenter prospective registry of consecutive patients hospitalized for COVID-19 pneumonia aged 18–65 years between March and May 2020. We considered a composite outcome of “poor outcome” including intensive care unit admission and/or use of noninvasive ventilation, continuous positive airway pressure or high flow nasal cannula oxygen and/or death.
Results
We identified 513 patients < 65 years of age, from a cohort of 993 patients. 102 had poor outcomes (19.8%) and 3.9% died. 78% and 55% of patients with poor outcomes were classified as low risk based on CURB and PSI scores, respectively.
A multivariate Cox regression model identified six independent factors associated with poor outcome: heart disease, absence of chest pain or anosmia, low oxygen saturation, high LDH and lymphocyte count < 800/mL.
Conclusions
COVID-19 in younger patients carries significant morbidity and differs in some respects from this disease in the elderly. Baseline heart disease is a relevant risk factor, while anosmia and pleuritic pain are associated to better prognosis. Hypoxemia, LDH and lymphocyte count are predictors of poor outcome. We consider that CURB and PSI scores are not suitable criteria for deciding admission in this population.
Læs mere
Tjek på PubMed
5
Post‐acute COVID‐19 syndrome (PCS) and Health related Quality of life (HRQoL)‐ A systematic review and Meta‐analysis.
Preeti Malik,
Karan Patel,
Candida Pinto,
Richa Jaiswal,
Raghavendra Tirupathi,
Shreejith Pillai,
Urvish Patel
Journal of Medical Virology, 31.08.2021
Tilføjet 1.09.2021
6
The phosphate language of fungi
Kabir Bhalla, Xianya Qu, Matthias Kretschmer, James W. Kronstad
Trends in Microbiology, 31.08.2021
Tilføjet 1.09.2021
Phosphate is an essential macronutrient for fungal proliferation as well as a key mediator of antagonistic, beneficial, and pathogenic interactions between fungi and other organisms. In this review, we summarize recent insights into the integration of phosphate metabolism with mechanisms of fungal adaptation that support growth and survival. In particular, we highlight aspects of phosphate sensing important for responses to stress and regulation of cell-surface changes with an impact on fungal pathogenesis, host immune responses, and disease outcomes.
Læs mere
Tjek på PubMed
7
Intermarriage and COVID-19 mortality among immigrants. A population-based cohort study from Sweden
Aradhya, S., Branden, M., Drefahl, S., Obucina, O., Andersson, G., Rostila, M., Mussino, E., Juarez, S. P.
BMJ Open, 1.09.2021
Tilføjet 1.09.2021
Objectives
To evaluate the role of language proficiency and institutional awareness in explaining excess COVID-19 mortality among immigrants.
Design
Cohort study with follow-up between 12 March 2020 and 23 February 2021.
Setting
Swedish register-based study on all residents in Sweden.
Participants
3 963 356 Swedish residents in co-residential unions who were 30 years of age or older and alive on 12 March 2020 and living in Sweden in December 2019.
Outcome measures
Cox regression models were conducted to assess the association between different constellations of immigrant-native couples (proxy for language proficiency and institutional awareness) and COVID-19 mortality and all other causes of deaths (2019 and 2020). Models were adjusted for relevant confounders.
Results
Compared with Swedish-Swedish couples (1.18 deaths per thousand person-years), both immigrants partnered with another immigrant and a native showed excess mortality for COVID-19 (HR 1.43; 95% CI 1.29 to 1.58 and HR 1.24; 95% CI 1.10 to 1.40, respectively), which translates to 1.37 and 1.28 deaths per thousand person-years. Moreover, similar results are found for natives partnered with an immigrant (HR 1.15; 95% CI 1.02 to 1.29), which translates to 1.29 deaths per thousand person-years. Further analysis shows that immigrants from both high-income and low-income and middle-income countries (LMIC) experience excess mortality also when partnered with a Swede. However, having a Swedish-born partner is only partially protective against COVID-19 mortality among immigrants from LMIC origins.
Conclusions
Language barriers and/or poor institutional awareness are not major drivers for the excess mortality from COVID-19 among immigrants. Rather, our study provides suggestive evidence that excess mortality among immigrants is explained by differential exposure to the virus.
Læs mere
Tjek på PubMed
8
Widespread Disease in Hedgehogs (Erinaceus europaeus) Caused by Toxigenic Corynebacterium ulcerans
Emerging Infectious Diseases, 31.08.2021
Tilføjet 1.09.2021
9
Natural Plasmodium inui Infections in Humans and Anopheles cracens Mosquito, Malaysia
Emerging Infectious Diseases, 31.08.2021
Tilføjet 1.09.2021
10
Genetic Characterization of Seoul Virus in the Seaport of Cotonou, Benin
Emerging Infectious Diseases, 31.08.2021
Tilføjet 1.09.2021
11
Indoor and Outdoor Rodent Hosts of Orientia tsutsugamushi, Shandong Province, China
Emerging Infectious Diseases, 31.08.2021
Tilføjet 1.09.2021
12
Nocardiosis in Immunocompromised Patients on Alternative Pneumocystis Prophylaxis
Emerging Infectious Diseases, 31.08.2021
Tilføjet 1.09.2021
13
Emergomyces orientalis Emergomycosis Diagnosed by Metagenomic Next-Generation Sequencing
Emerging Infectious Diseases, 31.08.2021
Tilføjet 1.09.2021
14
Rifampicin mono-resistant tuberculosis is not the same as multidrug-resistant tuberculosis: a descriptive study from Khayelitsha, South Africa
Zubeida Salaam-Dreyer
Elizabeth M. Streicher
Frederick A. Sirgel
Fabrizio Menardo
Sonia Borrell
Miriam Reinhard
Anna Doetsch
Patrick G.T. Cudahy
Erika Mohr-Holland
Johnny Daniels
Anzaan Dippenaar
Mark P. Nicol
Sebastien Gagneux
Robin M. Warren
Helen Cox
1Division of Medical Microbiology, Department of Pathology, University of Cape Town, South Africa
2DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
3Swiss Tropical and Public Health Institute, Basel Switzerland
4University of Basel, Basel, Switzerland
5Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA
6Médecins Sans Frontières, Khayelitsha, Cape Town, South Africa
7Tuberculosis Omics Research Consortium, Family Medicine and Population Health, Institute of Global Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
8Division of Infection and Immunity, School of Biomedical Sciences, University of Western Australia, Perth, Australia
9Institute of Infectious Disease and Molecular Medicine and Wellcome centre for Infectious Disease Research, University of Cape Town, South Africa
Antimicrobial Agents And Chemotherapy, 30.08.2021
Tilføjet 31.08.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Læs mere
Tjek på PubMed
15
Ribosome protection as a mechanism of lincosamide resistance in Mycobacterium abscessus
Kelley R. Hurst-Hess
Paulami Rudra
Pallavi Ghosh
1Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
2School of Public Health, University at Albany, Albany, NY 12208
Antimicrobial Agents And Chemotherapy, 30.08.2021
Tilføjet 31.08.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Læs mere
Tjek på PubMed
16
The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex
Roger Vargas
Luca Freschi
Andrea Spitaleri
Sabira Tahseen
Ivan Barilar
Stefan Niemann
Paolo Miotto
Daniela Maria Cirillo
Claudio U. Köser
Maha R. Farhat
1 Department of Systems Biology, Harvard Medical School, Boston, USA.
2 Department of Biomedical Informatics, Harvard Medical School, Boston, USA.
3 Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
4 National TB Reference laboratory, National TB Control Program, Islamabad, Pakistan.
5 German Center for Infection Research, Partner site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
6 Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
7 Department of Genetics, University of Cambridge, Cambridge, UK.
8 Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, USA.
Antimicrobial Agents And Chemotherapy, 30.08.2021
Tilføjet 31.08.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Læs mere
Tjek på PubMed
17
Pharmacokinetics, Tissue Distribution, and Efficacy of VIO-001 (Meropenem/Piperacillin/Tazobactam) for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia in Immunocompetent Rabbits with Chronic Indwelling Vascular Catheters
Vidmantas Petraitis
Ruta Petraitiene
Povilas Kavaliauskas
Ethan Naing
Andrew Garcia
Christina Sutherland
Aki Yoneda Kau
Nicholas Goldner
Christopher Bulow
David P. Nicolau
Thomas J. Walsh
a Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY, USA
b Viosera Therapeutics, Brentwood, MO, USA
c Center for Anti-Infective Research and Development at Hartford Hospital, Hartford, CT, USA
d Departments of Pediatrics, Weill Cornell Medicine of Cornell University, New York, NY, USA
e Microbiology and Immunology, Weill Cornell Medicine of Cornell University, New York, NY, USA
Antimicrobial Agents And Chemotherapy, 30.08.2021
Tilføjet 31.08.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Læs mere
Tjek på PubMed
18
The novel bis-1,2,4-triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite
Katherine M. Ellis
Leonardo Lucantoni
Marina Chavchich
Matthew Abraham
Amanda De Paoli
Madeline R. Luth
Anne-Marie Zeeman
Michael J. Delves
Fernando Sánchez-Román Terán
Ursula Straschil
Jake Baum
Clemens HM. Kocken
Stuart A. Ralph
Elizabeth A. Winzeler
Vicky M. Avery
Michael D. Edstein
Jonathan B. Baell
Darren J. Creek
aDrug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia
bDiscovery Biology, Griffith University, Nathan, QLD 4111, Australia
cThe Department of Drug Evaluation, Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD 4052, Australia
dSchool of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA
eDepartment of Parasitology, Biomedical Primate Research Centre, Rijswijk, Netherlands
fDepartment of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, SW7 2AZ, UK
gDepartment of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3052, Australia
hMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia
Antimicrobial Agents And Chemotherapy, 30.08.2021
Tilføjet 31.08.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Læs mere
Tjek på PubMed
19
A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
Qi Guo
Liyun Xu
Fusheng Tan
Yongjie Zhang
Junsheng Fan
Xinghai Wang
Zhemin Zhang
Bing Li
Haiqing Chu
aDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
bTongji University School of Medicine, Shanghai, China
cMicuRx Pharmaceuticals,Inc, Shanghai, China
dShanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
Antimicrobial Agents And Chemotherapy, 30.08.2021
Tilføjet 31.08.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Læs mere
Tjek på PubMed
20
Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences
Abdoulie Kanteh, Jarra Manneh, Sona Jabang, Mariama A. Kujabi, Bakary Sanyang, Mary A. Oboh, Abdoulie Bojang, Haruna S. Jallow, Davis Nwakanma, Ousman Secka, Anna Roca, Alfred Amambua-Ngwa, Martin Antonio, Ignatius Baldeh, Karen Forrest, Ahmadou Lamin Samateh, Umberto D’Alessandro, Abdul Karim Sesay
PLoS One Infectious Diseases, 31.08.2021
Tilføjet 31.08.2021
by Abdoulie Kanteh, Jarra Manneh, Sona Jabang, Mariama A. Kujabi, Bakary Sanyang, Mary A. Oboh, Abdoulie Bojang, Haruna S. Jallow, Davis Nwakanma, Ousman Secka, Anna Roca, Alfred Amambua-Ngwa, Martin Antonio, Ignatius Baldeh, Karen Forrest, Ahmadou Lamin Samateh, Umberto D’Alessandro, Abdul Karim Sesay
The SARS-CoV-2 disease, first detected in Wuhan, China, in December 2019 has become a global pandemic and is causing an unprecedented burden on health care systems and the economy globally. While the travel history of index cases may suggest the origin of infection, phylogenetic analysis of isolated strains from these cases and contacts will increase the understanding and link between local transmission and other global populations. The objective of this analysis was to provide genomic data on the first six cases of SARS-CoV-2 in The Gambia and to determine the source of infection. This ultimately provide baseline data for subsequent local transmission and contribute genomic diversity information towards local and global data. Our analysis has shown that the SARS-CoV-2 virus identified in The Gambia are of European and Asian origin and sequenced data matched patients’ travel history. In addition, we were able to show that two COVID-19 positive cases travelling in the same flight had different strains of SARS-CoV-2. Although whole genome sequencing (WGS) data is still limited in sub-Saharan Africa, this approach has proven to be a highly sensitive, specific and confirmatory tool for SARS-CoV-2 detection.
Læs mere
Tjek på PubMed